Press Releases

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Experts call on the World Health Organization, governments and medical communities to develop common classifications and systems to diagnose and treat age-related diseases.

An international team of researchers have put forward a position statement, published in Science, which lays out a new healthcare framework to help aging populations stay healthier for longer...
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The Buck gets $3.8 M Transformative Research Award from the NIH

A mouse that can regrow axons after brain injury is the focus of a new method to pinpoint genetic differences between species
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The Bia-Echo Foundation announces the Global Consortium for Female Reproductive Longevity and Equality in partnership with the Buck Institute

The Consortium will award $7...
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Cellular senescence is associated with age-related blood clots

Publishing in the September 24 edition of Cell Reports, researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots...
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Uric acid pathologies shorten lifespan in flies, highlighting the need for screening in humans

Backed by human genetics, research in flies provides potential drug targets for gout, metabolic syndrome, diabetes and kidney stones
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The Buck announces first faculty appointments for the Center for Female Reproductive Longevity and Equality

Lei Lei, PhD, Shiying Jin, PhD, Francesca Duncan, PhD, and Jennifer Garrison, PhD are the first faculty members to join the Buck Institute’s Center for Female Reproductive Longevity and Equality.
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Buck professor Gordon Lithgow receives prestigious award from the American Aging Association

Denham Harman Award recognizes lifetime achievement in research on aging
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Buck Professor Emeritus David Nicholls elected to the Royal Society

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Buck faculty help found Academy for Health and Lifespan Research

A group of the world’s leading scientists form nonprofit aimed at accelerating breakthroughs to extend human healthspan.
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Does dietary restriction protect against age-related leaky gut?

Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract...
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A new method to pinpoint genetic differences between species

Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms...
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Tara Tracy joins faculty at Buck Institute

Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s
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Three leaders in longevity biotechnology form a research collaboration

The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics
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World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging

A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's...
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First patient treated with drug based on Buck research

Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial
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Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials

Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project.
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Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty

Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice.
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A Potential New Therapeutic Approach for Parkinson’s Disease

A potential new therapeutic approach for Parkinson’s disease.
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Inhibiting TOR boosts regenerative potential of adult tissues

Rapamycin prevents age-related loss of stem cells
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Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research

The funding will Dr. Lisa Ellerby's work in Huntington's disease
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Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant

Chuankai Zhou is awarded prestigious Early Independence Award from NIH
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Some women with history of preeclampsia have significantly lower risk for breast cancer

Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant
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Large data set brings precision to breast cancer diagnosis and care

Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence
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Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project

The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity
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Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease

Buck Institute research leads to clinical trial for cystinuria at UCSF
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Senescence promotes chemotherapy side effects and cancer relapse

Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.
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Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells
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Research in worms provides a model to study how the microbiome influences disease in humans

The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity
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Buck Institute study provides neuronal mechanism for the benefits of fasting

The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function
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CEO of Buck Institute
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BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH

ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO
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Buck Institute Appoints Edward Lanphier President and CEO

The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer
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Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease

Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J...
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A new look at vitamin D challenges the current view of its benefits

Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases
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Research in worms provides path to study diabetic complications

Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems
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Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases

As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty...
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Future therapeutics: drugs that stop free radicals at their source

Research at the Buck Institute yields molecules that prevent free radical production by cells
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Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype

Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology
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Intracellular calcium integrates complex signaling to control stem cell activity

Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation
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Dietary restriction gives fruit flies a rhythm for a long life

Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development
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$1.25 million bequest funds first named professorship at Buck Institute

Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1...
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Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease

Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field.
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Buck Faculty Jennifer Garrison Announced as an Allen Institute for Brain Science 2015 Next Generation Leader

Assistant professor Jennifer Garrison, PhD, has been selected as one of this year’s six Next Generation Leaders at the Allen Institute for Brain Science...
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Mapping the Genes that Increase Lifespan

Comprehensive study finds 238 genes that affect aging in yeast cells.
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Surprising results in study of mitochondrial dysfunction in skin casts light on the free radical theory of aging

Scientists in the Campisi lab at the Buck Institute bred mice that produced excess free radicals that damaged the mitochondria in their skin
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An imbalance of cellular bioenergetics in pancreatic beta-cells is linked to type 2 diabetes

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes...
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Low-dose lithium prevents Parkinson’s symptoms in aged mice with a human mutation for the disease

Study provides further validation that lithium could be repurposed as a therapy for the incurable neurodegenerative disorder
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Senescent cells play an essential role in wound healing

Study highlights ability to avoid a potential side effect of healthspan extending drugs
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Could ibuprofen be an anti-aging medicine?

Study shows popular over-the counter drug extends lifespan in yeast, worms and flies
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Henri Jasper
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Buck Faculty Henri Jasper, PhD, Receives Prestigious BIG Award

Buck faculty Henri Jasper, PhD, gets prestigious “Breakthroughs in Gerontology” award from the Glenn Foundation and the American Federation for Aging Research
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Leading scientists identify research strategy for highly intertwined “pillars of aging”

Leading scientists identify research strategy for highly intertwined “pillars of aging” as next step in supporting the trans-NIH Geroscience Interest Group’s efforts to integrate aging into research on chronic diseases
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Memory loss associated with Alzheimer’s reversed for first time

In a novel, personalized and comprehensive program to reverse memory loss, nine of 10 participants displayed subjective or objective improvement in their memories
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Researchers propose “disruptive” new system to reclassify tumors

Largest cancer genomic study proposes “disruptive” new system to reclassify tumors
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Rachel Brem, PhD, Joins Buck Institute Faculty

Associate Professor studies naturally-occurring genetic variations that impact characteristics of aging
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Buck Institute Mourns Death of Catherine Munson, Long-Time Trustee and former Board Chair

Iconic Realtor was Community Activist and Philanthropist
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Five-Fold Lifespan Extension in C. Elegans by Combining Mutants

Research Highlights Possibility of Combination Therapy for Aging
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Aging Impacts Epigenome in Human Skeletal Muscle

Buck Institute research involves first genome-wide DNA methylation study in disease-free tissue
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The Buck Institute for Research on Aging and the University of Southern California Launch the Nation’s First PhD Program in the Biology of Aging

Program is a Landmark in the History of the Buck
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Major Alzheimer’s Risk Factor Linked to Red Wine Target

Buck Institute study provides insight for new therapeutics that target the interaction between ApoE4 and a Sirtuin protein
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Research in Aging Fruit Flies May Explain the Roots of Metabolic Dysfunction in Aging Humans

Findings provide a rationale for "Why We Just Can’t Eat What We Used To"
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Buck Institute Adds Two New Faculty

Their research focuses on very different realms of the nervous system
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Research in Fruit Flies Provides New Insight into Barrett’s Esophagus

A new study suggests a change in stem cell function causes cells in lower esophagus to transform into stomach-like cells
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Buck Faculty Receives Prestigious Tenovus Award

Buck faculty Gordon Lithgow, PhD, has received the prestigious 2013 Tenovus-Scotland Medal
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Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

Rapamycin is already FDA approved for other indications
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Buck Scientists Publish Genome-Scale Study Identifying Hundreds of Potential Drug Targets for Huntington’s Disease

Scientists searching for ways to develop treatments for Huntington’s disease (HD) just got a roadmap that could dramatically speed their discovery process
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Arthur and Drue Gensler Donate $5 Million to Buck Institute

Gift from Board Member and Architectural Visionary Will be Honored by the Naming of Administrative Building
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Advanced Courses for Scientists
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Buck Institute Announces its Founding Partnership with Delos Pharmaceuticals

New Company is Developing Therapeutics for Age-Associated Disease
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Buck Institute and UC Santa Cruz Collaborators Make Significant Contribution to Landmark Breast Cancer Study

TCGA study demonstrates existence of four main classes of breast cancer; Buck collaboration points to similarities between a type of breast and ovarian cancer
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Stem Cell Agency Awards Buck Faculty $1.5 Million to Make 3-D Model of the Retina

Efforts to understand and treat degenerative eye diseases utilizing stem cell technology just got a boost
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Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

FDA-approved drug improves cardiac and skeletal muscle function and extends lifespan
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Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process
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Buck Scientists Correct Huntington’s Disease Mutation in Induced Pluripotent Stem Cells

Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington’s disease (HD) using a human induced pluripotent stem cell
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Glenn Foundation Awards Buck Institute $1 Million to Establish Training Fellowships in the Biology of Aging

The monies will bring new postdoctoral fellows to the Buck Institute, funding two years of research for each of 10 scientists
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Management Consultant, Community Leader James Edgar Elected to Chair Buck Institute Board of Trustees

James M. Edgar, a life-long management consultant and community leader has been elected Chair of the Board of Trustees
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Buck Institute Adds Two New Faculty

Stem cell technologies will be utilized to study vision disorders and skeletal muscle physiology
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Scientists Turn Back the Clock on Adult Stem Cells Aging

Reversing the aging process could lead to medical treatments for many chronic conditions
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Researchers Flip the Switch Between Aging and Development in C. elegans

Buck Institute scientists note first observation of genome-wide shift kicked off at level of translation that extends lifespan
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Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease

Buck Institute research in mice moves into preclinical stage; Buck working toward human trial
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John W. “Jack” Rowe Donates $1 Million to Buck Institute

Gift from healthcare visionary who helped establish the Buck is announced at the kick-off event for the new Buck Advisory Council.
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A New Role for Endocannabinoid Signaling in Dietary Restriction and Lifespan Extension

Study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability
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Common Laboratory Dye is a Wonder Drug — for Worms

Study in Nature shows Basic Yellow 1 profoundly extends lifespan in healthy nematodes, and slows Alzheimer's disease-like pathology in worms
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Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD

Physician-Scientist was a Pioneer in Medical Genetics, Down Syndrome and Aging Research
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Novel Method Results in Promising Drugs for Huntington’s Disease Therapeutics

Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are underway in mice
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Buck Institute Awarded $6 Million to Lead Effort to Get Stem Cell Treatment for Parkinson’s Disease Ready for Clinical Trials

The Buck Institute for Age Research has been awarded $6 million from the California Institute for Regenerative Medicine to fund a three-year project aimed at getting a stem cell derived treatment for Parkinson's disease
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A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response

Buck Institute study says it’s about translation, not just transcription
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Scientists Successfully Use Human Induced Pluripotent Stem Cells to Treat Parkinson’s Disease in Rodents

Technologies developed at Buck Institute can speed the manufacturing of authentic neurons from stem cells for future clinical applications
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BIOMARIN - Providing innovative therapeutics to patients with serious unmet medical needs.
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Buck Institute Partners with BioMarin to Expand Early Research on Novel Treatment for Familial Alzheimer’s Disease

The Buck Institute for Age Research announced that it has entered into a research collaboration with BioMarin Pharmaceutical Inc...
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Leap Forward in Efforts to Develop Treatments for Huntington’s Disease

Buck Institute scientists identify new targets for drug development, some of which already respond to cancer drugs
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Brian K. Kennedy, PhD, Appointed as New CEO of Buck Institute for Age Research

Kennedy, who has earned an international reputation for his work in the basic biology of aging, comes to the Buck Institute from the University of Washington in Seattle where he most recently served in the Department of Biochemistry
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Fruit Flies Provide New Clues on How Organisms Make Dietary Choices

Research at Buck Institute for Age Research opens the door for future treatments for metabolic and eating disorders
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Buck Institute Study Suggests New Strategy for Treatment of Stroke

Research in rodents highlights need for human clinical trials of antidepressants and other drugs shown to increase growth of new neurons
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Buck Institute Awarded $1.5 Million for Stem Cell Training

Three-year grant from California Institute for Regenerative Medicine will bring six new postdoctoral fellows to the Buck
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“Anti-Atkins” Low Protein Diet Extends Lifespan in Flies

Diet boosts mitochondrial function, has implications for humans
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DNA Damaged Cells Communicate with Neighbors to Let them Know They’re in Trouble

Buck Institute research has implications in aging and cancer
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NIH supports Buck Institute’s Innovative Alzheimer’s Research with $1.6 Million “EUREKA” Grant

The highly competitive grant was awarded to Buck faculty member and founding CEO Dale Bredesen, MD...
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Buck Scientists Identify a Key Protein That May Explain the Anti-Aging and Anti-Cancer Benefits of Dietary Restriction

The finding provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.
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Sean Mooney, PhD, Joins Buck Faculty

Appointment highlights emphasis on bioinformatics and collaborative research
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Escape Cancer, But Age Sooner?

Buck Institute scientists unravel the dark side of the tumor suppressing process
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Buck Institute Study Shows Mixed Results for Life-Extending Properties of Antioxidants

Findings underscore need for consumer caution when taking supplements
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Buck Institute Receives $1.5 Million from Keck Foundation to Study Aging As Causal Factor for Disease

The research from Julie Andersen, PhD and Brad Gibson, PhD will bring together the disciplines of neuroscience, mitochondrial proteomics, functional bioenergetics and the biology of aging to test an idea that is likely to influence the way the biomedical community views research on age-related disease.
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Martin Brand, PhD, Joins Buck Faculty

Appointment establishes Institute’s research focus on diabetes
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Growth Factor Promotes New Neuron Growth in Mouse Model of Parkinson’s Disease

Mice induced to develop Parkinson’s disease (PD) show an increase in the growth of new neurons after they are treated with a well known growth factor...
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Buck Institute Receives $20.5 Million for New Stem Cell Building

The CIRM award would provide seed money for the institute’s second research facility...
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Victoria Lunyak, PhD, Joins Buck Faculty

Appointment establishes program in epigenetics and aging
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Paradoxical Alzheimer’s Finding May Shed New Light on Memory Loss

The study provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD.
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Buck Institute Announces Senior Management Change

Dale Bredesen, MD, will discontinue his duties as CEO to spend more time on a private start-up health promotion and disease prevention company that he recently co-founded...
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Glutathione Depletion Leads to Symptoms of Parkinson’s Disease in Mice

Buck Institute study provides new model for the study of the neurodegenerative disease while highlighting the role of aging in disease development
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Drug Commonly Used to Treat Bi-Polar Disorder Dramatically Increases Lifespan in Nematode Worms

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Buck Institute Awarded $25 Million to Establish New Scientific Discipline of Geroscience

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Combined Exposure to Environmental Toxics Accelerates Age-Related Development of Parkinson’s Disease in Mice

Buck Institute study highlights the role of environmental factors in the most common form of the neurodegenerative disease
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Buck Institute Awarded $4.1 Million for Shared Research and Laboratory and Training Facility for Human Embryonic Stem Cell Research

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Exercise Reverses Aging in Human Skeletal Muscle

Buck Institute faculty lead study showing “genetic fingerprints” becoming younger in healthy seniors who did resistance training
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Landmark Study Identifies a Large Number of New Proteins Implicated in Huntington’s Disease

Buck Institute faculty leads large scale screening of protein interactions to identify drug targets for possible treatment of incurable neurodegenerative disease
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Unprecedented Screening of Up to 120,000 Chemical Compounds for Lifespan Extension to Begin

Grant establishes “Hillblom Chemical Biology of Aging Network” at Buck Institute for Age Research
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Overexpression of Human Protein Reduces Severity of Alzheimer’s Disease in Mice

Ultimate goal of research is to identify drugs which boost the body’s attempt to heal itself
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Buck Institute Study Finds Inflammation is a Culprit in Nerve Death in Mouse Model of Parkinson’s Disease

Discovery offers new model to explore anti-inflammatory treatments for progressive, incurable neurodegenerative disease
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Buck Institute Study Shows Newborn Neurons May Promote Stroke Recovery in Humans

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Is it Time to Reexamine Iron Content in Infant Formula?

Neonatal mice fed the equivalent amount of iron used in human infant formula develop Parkinson’s-like neurodegeneration as they age
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Proteins Linked to Cancer Prevention in Humans Affect Aging in Worms

Discovery opens a new avenue of inquiry into aging as a risk factor for cancer
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Buck Study Provides a Startling New Look at Alzheimer’s

Mouse brains look like Alzheimer’s, but mouse memories do just fine
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Growth Factor Promotes New Neuron Growth and Increased Survival in Mice with Huntington’s Disease

Buck Institute study shows potential for new avenue of treatment for incurable, hereditary brain disorder
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“Fruit Fly” Researcher Joins Buck Institute

Other Adjunct Appointments Mark 5-year Anniversary
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Buck Scientists Identify “Jekyll-Hyde” Cancer Gene

New Finding Challenges Traditional View of Cancer Genes
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Buck Institute Study Shows Birth of New Nerve Cells Increased in Patients with Alzheimer’s Disease

Stimulating Neurogenesis May Provide New Treatment Strategies
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Here’s what’s happening

Upcoming events at the Buck

Ongoing

Formal Research Seminars

Click “read more” for full schedule

New in @naturemedicine today: A perspective piece on the role of #chronicinflammation in disease. Congrats to Buck authors Dr. David Furman, Dr. Judy Campisi, and @EricVerdin! #livebetterlonger https://www.nature.com/articles/s41591-019-0675-0

The bad side of aging is the #disease that comes with it. Developing good #biomarkers for aging can help assess disease risk and support early intervention so we can #livebetterlonger https://www.eurekalert.org/pub_releases/2019-12/uoc-shp112719.php

Join us in supporting the next generation of scientists in research on longevity! Together, we can lead the charge against age-related diseases and help us all #livebetterlonger Donate! https://www.buckinstitute.org/support/?modalopen=true?BBFund=108

Increasing #stemcells is not always good. #Highfatdiet leads to more intestinal stem cells, which may be a driver of #colorectalcancer. A study from @RutgersNB finds that genes HNF4A and HNF4G likely regulate how stem cells burn fat #livebetterlonger https://www.eurekalert.org/pub_releases/2019-11/ru-isc112219.php

Your ancestors didn’t survive dust and rotting meat aerosols just so you could smoke cigarettes. However, #genes related to toxin clearance likely play a role in surviving both ancient and modern airborne toxins #livebetterlonger https://www.eurekalert.org/pub_releases/2019-11/uocp-sgm112519.php