Press Releases

Press Release . Jun 01, 2021

Huntington’s disease: Modulating rapamycin target protein FKBP51 pathway promotes autophagy, lowering Huntingtin protein

Experiments with small molecule has implications for research on aging.

Press Release . Mar 09, 2021

A new predictive model helps identify those at risk for severe COVID-19

Buck scientists analyze data from 3 million people using a smartphone app in the United Kingdom

Press Release . Jan 26, 2021

A compound that slows bone loss, and a resource for developing treatments to slow aging

Longitudinal and functional study of 700 aging mice provides a treasure trove of data for those studying aging and age-related diseases

Press Release . Jan 12, 2021

Tissue stiffness likely drives immune responses in many chronic diseases

Buck research points to the possibility of new immunotherapeutics and highlights critically needed changes in experimental techniques

Press Release . Dec 16, 2020

Buck Institute Names Malene Hansen as Chief Scientific Officer

Dr. Malene Hansen is joining the Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission”

Press Release . Nov 16, 2020

Chronic inflammation causes a reduction in NAD+

Buck research links hallmarks of aging: senescent cells activate CD38 which degrades NAD+, a key metabolite implicated in age-related decline

Press Release . Sep 01, 2020

A metabolite produced by the body increases lifespan and dramatically compresses late-life morbidity in mice

Alpha-ketaglutarate improves several measures of healthspan in double-blind study

Press Release . Aug 10, 2020

Global Consortium for Reproductive Longevity & Equality Announces First Grant Recipients

22 Researchers Selected to Receive $7...

Press Release . Jul 16, 2020

USC Leonard Davis School of Gerontology and The Buck Institute for Research on Aging Win $4.6 Million NIA Grant

Prestigious award establishes the USC-Buck Nathan Shock Center of Excellence in the Basic Biology of Aging.

Press Release . Jul 15, 2020

Researchers outline strategy for testing ketone bodies against COVID-19, other respiratory infections

Review in Med highlights the role of geroscience in the fight against this and future pandemics.

Press Release . Jun 22, 2020

New tools will enhance the specificity of imaging in the mouse brain

Researchers image neural circuits by targeting the cell body using ribosome tethering

Press Release . Jun 03, 2020

Eat less and live a long healthy life? Study shows “not in all cases”

Results from research involving 160 genetically distinct strains of fruit flies give insight into what will likely happen in humans using dietary restriction to add extra years (and extra health) to life.

Press Release . Jan 29, 2020

Buck researchers discover how cellular senescence leads to neurodegeneration

Findings available to scientists studying both dementia and brain cancer.

news . Jan 16, 2020

Stage is set to develop clinically relevant, senescence-based biomarkers of aging

Proteomic Atlas of Senescence-Associated Secretomes can be used by the research community to speed translation of therapeutics to clinical use

Press Release . Oct 31, 2019

Experts call on the World Health Organization, governments and medical communities to develop common classifications and systems to diagnose and treat age-related diseases.

An international team of researchers have put forward a position statement, published in Science, which lays out a new healthcare framework to help aging populations stay healthier for longer...

Press Release . Oct 01, 2019

The Buck gets $3.8 M Transformative Research Award from the NIH

A mouse that can regrow axons after brain injury is the focus of a new method to pinpoint genetic differences between species

Press Release . Sep 30, 2019

The Bia-Echo Foundation announces the Global Consortium for Female Reproductive Longevity and Equality in partnership with the Buck Institute

The Consortium will award $7...

Press Release . Sep 24, 2019

Cellular senescence is associated with age-related blood clots

Publishing in the September 24 edition of Cell Reports, researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots...

Press Release . Aug 15, 2019

Uric acid pathologies shorten lifespan in flies, highlighting the need for screening in humans

Backed by human genetics, research in flies provides potential drug targets for gout, metabolic syndrome, diabetes and kidney stones

Press Release . Jun 17, 2019

The Buck announces first faculty appointments for the Center for Female Reproductive Longevity and Equality

Lei Lei, PhD, Shiying Jin, PhD, Francesca Duncan, PhD, and Jennifer Garrison, PhD are the first faculty members to join the Buck Institute’s Center for Female Reproductive Longevity and Equality.

Press Release . May 31, 2019

Buck professor Gordon Lithgow receives prestigious award from the American Aging Association

Denham Harman Award recognizes lifetime achievement in research on aging

Press Release . Apr 17, 2019

Buck Professor Emeritus David Nicholls elected to the Royal Society

Press Release . Feb 14, 2019

Buck faculty help found Academy for Health and Lifespan Research

A group of the world’s leading scientists form nonprofit aimed at accelerating breakthroughs to extend human healthspan.

news . Feb 12, 2019

Intervening in glial cells protects neurons in Parkinson’s model

Buck researchers identify crosstalk between dopaminergic neurons and glial cells in fruit flies providing a potential new target for preventative treatment.

news . Jan 15, 2019

MANF identified as a rejuvenating factor in parabiosis

Buck researchers also harness an innate repair mechanism to protect against liver damage in aging mice and extend lifespan in flies...

Press Release . Nov 06, 2018

Does dietary restriction protect against age-related leaky gut?

Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract...

Press Release . Oct 08, 2018

A new method to pinpoint genetic differences between species

Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms...

Press Release . Aug 28, 2018

Tara Tracy joins faculty at Buck Institute

Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s

Press Release . Aug 14, 2018

Three leaders in longevity biotechnology form a research collaboration

The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics

Press Release . Jul 25, 2018

World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging

A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's...

Press Release . Jul 09, 2018

First patient treated with drug based on Buck research

Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial

Press Release . Apr 05, 2018

Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials

Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project.

Press Release . Mar 13, 2018

Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty

Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice.

Press Release . Jan 23, 2018

A Potential New Therapeutic Approach for Parkinson’s Disease

A potential new therapeutic approach for Parkinson’s disease.

Press Release . Dec 07, 2017

Inhibiting TOR boosts regenerative potential of adult tissues

Rapamycin prevents age-related loss of stem cells

Press Release . Nov 20, 2017

Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research

The funding will Dr. Lisa Ellerby's work in Huntington's disease

Press Release . Oct 05, 2017

Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant

Chuankai Zhou is awarded prestigious Early Independence Award from NIH

Press Release . Aug 29, 2017

Some women with history of preeclampsia have significantly lower risk for breast cancer

Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant

Press Release . May 04, 2017

Large data set brings precision to breast cancer diagnosis and care

Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence

Press Release . Feb 21, 2017

Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project

The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity

Press Release . Feb 06, 2017

Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease

Buck Institute research leads to clinical trial for cystinuria at UCSF

Press Release . Jan 17, 2017

Senescence promotes chemotherapy side effects and cancer relapse

Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.

Press Release . Jan 12, 2017

Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells

news . Jan 04, 2017

Real Estate Entrepreneur Bill Poland Chairs Buck Institute Board of Trustees

Prominent San Francisco commercial real estate developer Bill R...

Press Release . Dec 13, 2016

Research in worms provides a model to study how the microbiome influences disease in humans

The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity

Press Release . Dec 01, 2016

Buck Institute study provides neuronal mechanism for the benefits of fasting

The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function

Press Release . Nov 18, 2016

BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH

ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO

Press Release . Oct 28, 2016

Buck Institute Appoints Edward Lanphier President and CEO

The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer

Press Release . Oct 18, 2016

Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease

Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J...

Press Release . Oct 18, 2016

A new look at vitamin D challenges the current view of its benefits

Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases

Press Release . Oct 13, 2016

Research in worms provides path to study diabetic complications

Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems

Press Release . Oct 13, 2016

Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases

As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty...

Press Release . Sep 15, 2016

Future therapeutics: drugs that stop free radicals at their source

Research at the Buck Institute yields molecules that prevent free radical production by cells

news . Aug 24, 2016

Buck faculty Jennifer Garrison, PhD, receives prestigious $2.5 million award from NIH

Five-year MIRA grant supports lab-based research on neuropeptide signaling

news . Jul 28, 2016

Buck Institute study sheds light on gender differences in diabetes and aging

All’s not fair in love and glucose intolerance

news . Jul 06, 2016

Improving on a broccoli-related compound yields a possible treatment for macular degeneration

Buck Institute study also shows that palmitoleic acid protects the retina from environmental damage in mouse models of disease.

news . Jul 05, 2016

Metformin as a potential treatment for a rare pediatric disorder

Study in human skin cells and mice shows widely-used diabetes drug reduces toxic acid levels in Maple Syrup Urine Disease

news . Jun 15, 2016

Pre and post testing show reversal of memory loss from Alzheimer’s disease in ten patients

Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders

news . Jun 01, 2016

Buck researchers identify new “druggable” target for sporadic Parkinson’s disease

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson’s disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally...

news . May 26, 2016

Can we extend healthspan by altering the perception of food?

Tricking C elegans into a state of caloric restriction extends lifespan by 50% and suggests new targets for human pharmacology

news . May 17, 2016

Buck research may provide missing link in search for Parkinson’s disease therapeutics

Largest collection of induced pluripotent stem cell lines and related genomic assays from Parkinson’s patients provide a disease model which will be available to researchers world-wide

news . Mar 23, 2016

The Glenn Center for Biology of Aging Research Established at the Buck Institute

It is increasingly clear that inter-connected mechanisms drive age-related disease...

news . Feb 10, 2016

A new method furthers understanding of evolutionary genetics

Publishing in Nature Genetics, discovery helps unravel the mystery of ancient traits

news . Feb 10, 2016

Inhibiting age-related inflammation maintains healthy gut microbiota and extends lifespan

Blocking a well-known inflammatory pathway in the fly prevents abnormal changes in gut tissue, benefits gut bacteria and delays functional decline associated with age

news . Jan 22, 2016

The connection between excess iron and Parkinson’s disease

Excess iron impairs cellular recycling resulting in toxic oxidative stress

news . Jan 13, 2016

A surprising new role for ApoE offers explanation for its diverse range of effects, particularly in Alzheimer’s

Buck Institute/UCLA study finds that apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes...

Press Release . Dec 10, 2015

Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype

Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology

Press Release . Nov 30, 2015

Intracellular calcium integrates complex signaling to control stem cell activity

Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation

Press Release . Nov 18, 2015

Dietary restriction gives fruit flies a rhythm for a long life

Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development

Press Release . Oct 22, 2015

$1.25 million bequest funds first named professorship at Buck Institute

Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1...

Press Release . Oct 16, 2015

Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease

Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field.

Press Release . Oct 13, 2015

Buck Faculty Jennifer Garrison Announced as an Allen Institute for Brain Science 2015 Next Generation Leader

Assistant professor Jennifer Garrison, PhD, has been selected as one of this year’s six Next Generation Leaders at the Allen Institute for Brain Science...

Press Release . Oct 05, 2015

Mapping the Genes that Increase Lifespan

Comprehensive study finds 238 genes that affect aging in yeast cells.

Press Release . Jul 29, 2015

Surprising results in study of mitochondrial dysfunction in skin casts light on the free radical theory of aging

Scientists in the Campisi lab at the Buck Institute bred mice that produced excess free radicals that damaged the mitochondria in their skin

Press Release . Jul 28, 2015

An imbalance of cellular bioenergetics in pancreatic beta-cells is linked to type 2 diabetes

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes...

news . Jul 24, 2015

Low-dose lithium reduces side effects from most common treatment for Parkinson’s disease

Buck Institute research provides further validation that low-dose lithium could be repurposed as a therapy for the incurable neurodegenerative disorder

news . Jun 20, 2015

New paradigm for treating “inflammaging” and cancer

Intermittent dosing with rapamycin breaks inflammatory loop that fuels tumor relapse and age-related diseases

news . Jun 04, 2015

Serotonin receptor is involved in eczema and other itch conditions

Dermatologists have long known that available treatments for chronic itch, including eczema, are simply not up to scratch...

news . May 25, 2015

Complex signaling between blood and stem cells controls regeneration in fly gut

Buck Institute scientists say impaired interactions between macrophages and stem cells are likely players in human intestinal maladies like IBS, leaky gut and colorectal cancers

news . Apr 28, 2015

Calico enters into agreement with the Buck Institute to conduct research into the biology of aging and to identify potential therapeutics for age-related diseases

Calico, a company focused on aging research and therapeutics, and the Buck Institute for Research on Aging have partnered to support research into longevity and age-related diseases...

news . Feb 09, 2015

Mechanistic finding may provide a means to deal with side effects of lifespan-extending drug rapamycin

Rapamycin, an FDA-approved drug, extends lifespan in mice up to 30%

news . Jan 21, 2015

Buck Institute faculty Judith Campisi receives first Olav Thon Foundation Prize

Norway’s largest charitable foundation bestows cash prize for Campisi’s pioneering work on cancer and aging

news . Jan 15, 2015

Is there a connection between heavy metals and aging?

Study in C...

Press Release . Dec 16, 2014

Low-dose lithium prevents Parkinson’s symptoms in aged mice with a human mutation for the disease

Study provides further validation that lithium could be repurposed as a therapy for the incurable neurodegenerative disorder

Press Release . Dec 14, 2014

Senescent cells play an essential role in wound healing

Study highlights ability to avoid a potential side effect of healthspan extending drugs

Press Release . Dec 11, 2014

Could ibuprofen be an anti-aging medicine?

Study shows popular over-the counter drug extends lifespan in yeast, worms and flies

Press Release . Nov 15, 2014

Buck Faculty Henri Jasper, PhD, Receives Prestigious BIG Award

Buck faculty Henri Jasper, PhD, gets prestigious “Breakthroughs in Gerontology” award from the Glenn Foundation and the American Federation for Aging Research

Press Release . Nov 06, 2014

Leading scientists identify research strategy for highly intertwined “pillars of aging”

Leading scientists identify research strategy for highly intertwined “pillars of aging” as next step in supporting the trans-NIH Geroscience Interest Group’s efforts to integrate aging into research on chronic diseases

Press Release . Sep 29, 2014

Memory loss associated with Alzheimer’s reversed for first time

In a novel, personalized and comprehensive program to reverse memory loss, nine of 10 participants displayed subjective or objective improvement in their memories

Press Release . Aug 07, 2014

Researchers propose “disruptive” new system to reclassify tumors

Largest cancer genomic study proposes “disruptive” new system to reclassify tumors

Press Release . Mar 06, 2014

Rachel Brem, PhD, Joins Buck Institute Faculty

Associate Professor studies naturally-occurring genetic variations that impact characteristics of aging

Press Release . Mar 04, 2014

Buck Institute Mourns Death of Catherine Munson, Long-Time Trustee and former Board Chair

Iconic Realtor was Community Activist and Philanthropist

news . Feb 26, 2014

New at the Buck: Huntington disease protein network

Researchers at the Buck Institute have identified and categorized thousands of protein interactions involving huntingtin, the protein responsible for Huntington’s disease (HD)...

news . Feb 18, 2014

Buck faculty Jennifer Garrison, PhD, Named 2014 Sloan Research Fellow by the Alfred P. Sloan Foundation

Buck Assistant Professor Jennifer Garrison, PhD, has been awarded a prestigious Sloan Research Fellowship

news . Jan 09, 2014

Altering Community of Gut Bacteria Promotes Health and Increases Lifespan

Study provides first systemic understanding of aging gut

Press Release . Dec 12, 2013

Five-Fold Lifespan Extension in C. Elegans by Combining Mutants

Research Highlights Possibility of Combination Therapy for Aging

Press Release . Nov 20, 2013

Aging Impacts Epigenome in Human Skeletal Muscle

Buck Institute research involves first genome-wide DNA methylation study in disease-free tissue

Press Release . Nov 20, 2013

The Buck Institute for Research on Aging and the University of Southern California Launch the Nation’s First PhD Program in the Biology of Aging

Program is a Landmark in the History of the Buck

Press Release . Oct 21, 2013

Major Alzheimer’s Risk Factor Linked to Red Wine Target

Buck Institute study provides insight for new therapeutics that target the interaction between ApoE4 and a Sirtuin protein

Press Release . Oct 14, 2013

Research in Aging Fruit Flies May Explain the Roots of Metabolic Dysfunction in Aging Humans

Findings provide a rationale for "Why We Just Can’t Eat What We Used To"

Press Release . Sep 10, 2013

Buck Institute Adds Two New Faculty

Their research focuses on very different realms of the nervous system

Press Release . Jun 26, 2013

Research in Fruit Flies Provides New Insight into Barrett’s Esophagus

A new study suggests a change in stem cell function causes cells in lower esophagus to transform into stomach-like cells

Press Release . Jun 17, 2013

Buck Faculty Receives Prestigious Tenovus Award

Buck faculty Gordon Lithgow, PhD, has received the prestigious 2013 Tenovus-Scotland Medal

Press Release . Jun 10, 2013

Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

Rapamycin is already FDA approved for other indications

news . Apr 21, 2013

CDI Partners with Buck to Derive and Bank iPSCs

Cellular Dynamics International Opens Facility in California, Leasing Space from the Buck Institute to Derive and Bank Human Induced Pluripotent Stem Cells

Press Release . Nov 29, 2012

Buck Scientists Publish Genome-Scale Study Identifying Hundreds of Potential Drug Targets for Huntington’s Disease

Scientists searching for ways to develop treatments for Huntington’s disease (HD) just got a roadmap that could dramatically speed their discovery process

Press Release . Nov 01, 2012

Arthur and Drue Gensler Donate $5 Million to Buck Institute

Gift from Board Member and Architectural Visionary Will be Honored by the Naming of Administrative Building

Press Release . Oct 25, 2012

Buck Institute Announces its Founding Partnership with Delos Pharmaceuticals

New Company is Developing Therapeutics for Age-Associated Disease

Press Release . Sep 22, 2012

Buck Institute and UC Santa Cruz Collaborators Make Significant Contribution to Landmark Breast Cancer Study

TCGA study demonstrates existence of four main classes of breast cancer; Buck collaboration points to similarities between a type of breast and ovarian cancer

Press Release . Sep 06, 2012

Stem Cell Agency Awards Buck Faculty $1.5 Million to Make 3-D Model of the Retina

Efforts to understand and treat degenerative eye diseases utilizing stem cell technology just got a boost

Press Release . Jul 25, 2012

Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

FDA-approved drug improves cardiac and skeletal muscle function and extends lifespan

Press Release . Jul 02, 2012

Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process

Press Release . Jun 28, 2012

Buck Scientists Correct Huntington’s Disease Mutation in Induced Pluripotent Stem Cells

Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington’s disease (HD) using a human induced pluripotent stem cell

Press Release . Jun 15, 2012

Glenn Foundation Awards Buck Institute $1 Million to Establish Training Fellowships in the Biology of Aging

The monies will bring new postdoctoral fellows to the Buck Institute, funding two years of research for each of 10 scientists

news . May 21, 2012

Modifying Scar Tissue Can Potentially Improve Outcome in Chronic Stroke

Buck Institute animal study builds on spinal cord injury research

news . Apr 12, 2012

New Regenerative Medicine Research Center to Open at Buck Institute

Public Invited to April 14 Open House/Ribbon Cutting

news . Mar 28, 2012

Buck Institute Helps Launch National “Healthspan Campaign”

Press Event in Washington, DC is hosted by Alliance for Aging Research

news . Jan 31, 2012

Need an Excuse to Book a Massage? Research Shows it Reduces Inflammation and Promotes Growth of New Mitochondria Following Strenuous Exercise

Massage reduces inflammation and promotes the growth of new mitochondria in skeletal muscle

Press Release . Dec 20, 2011

Management Consultant, Community Leader James Edgar Elected to Chair Buck Institute Board of Trustees

James M. Edgar, a life-long management consultant and community leader has been elected Chair of the Board of Trustees

Press Release . Sep 27, 2011

Buck Institute Adds Two New Faculty

Stem cell technologies will be utilized to study vision disorders and skeletal muscle physiology

Press Release . Sep 19, 2011

Scientists Turn Back the Clock on Adult Stem Cells Aging

Reversing the aging process could lead to medical treatments for many chronic conditions

Press Release . Jun 30, 2011

Researchers Flip the Switch Between Aging and Development in C. elegans

Buck Institute scientists note first observation of genome-wide shift kicked off at level of translation that extends lifespan

Press Release . Jun 20, 2011

Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease

Buck Institute research in mice moves into preclinical stage; Buck working toward human trial

Press Release . Jun 01, 2011

John W. “Jack” Rowe Donates $1 Million to Buck Institute

Gift from healthcare visionary who helped establish the Buck is announced at the kick-off event for the new Buck Advisory Council.

Press Release . May 11, 2011

A New Role for Endocannabinoid Signaling in Dietary Restriction and Lifespan Extension

Study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability

Press Release . Mar 30, 2011

Common Laboratory Dye is a Wonder Drug — for Worms

Study in Nature shows Basic Yellow 1 profoundly extends lifespan in healthy nematodes, and slows Alzheimer's disease-like pathology in worms

Press Release . Feb 16, 2011

Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD

Physician-Scientist was a Pioneer in Medical Genetics, Down Syndrome and Aging Research

Press Release . Nov 04, 2010

Novel Method Results in Promising Drugs for Huntington’s Disease Therapeutics

Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are underway in mice

Press Release . Oct 21, 2010

Buck Institute Awarded $6 Million to Lead Effort to Get Stem Cell Treatment for Parkinson’s Disease Ready for Clinical Trials

The Buck Institute for Age Research has been awarded $6 million from the California Institute for Regenerative Medicine to fund a three-year project aimed at getting a stem cell derived treatment for Parkinson's disease

Press Release . Sep 07, 2010

A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response

Buck Institute study says it’s about translation, not just transcription

Press Release . Aug 16, 2010

Scientists Successfully Use Human Induced Pluripotent Stem Cells to Treat Parkinson’s Disease in Rodents

Technologies developed at Buck Institute can speed the manufacturing of authentic neurons from stem cells for future clinical applications

Press Release . Aug 16, 2010

Buck Institute Partners with BioMarin to Expand Early Research on Novel Treatment for Familial Alzheimer’s Disease

The Buck Institute for Age Research announced that it has entered into a research collaboration with BioMarin Pharmaceutical Inc...

Press Release . Jul 25, 2010

Leap Forward in Efforts to Develop Treatments for Huntington’s Disease

Buck Institute scientists identify new targets for drug development, some of which already respond to cancer drugs

Press Release . Jun 28, 2010

Brian K. Kennedy, PhD, Appointed as New CEO of Buck Institute for Age Research

Kennedy, who has earned an international reputation for his work in the basic biology of aging, comes to the Buck Institute from the University of Washington in Seattle where he most recently served in the Department of Biochemistry

Press Release . May 13, 2010

Fruit Flies Provide New Clues on How Organisms Make Dietary Choices

Research at Buck Institute for Age Research opens the door for future treatments for metabolic and eating disorders

Press Release . Apr 07, 2010

Buck Institute Study Suggests New Strategy for Treatment of Stroke

Research in rodents highlights need for human clinical trials of antidepressants and other drugs shown to increase growth of new neurons

news . Feb 08, 2010

Comprehensive Study Using Bioinformatics Predicts the Molecular Causes of Many Genetic Diseases

Research spearheaded at the Buck Institute results in a web-based tool available to other scientists

Press Release . Dec 15, 2009

Buck Institute Awarded $1.5 Million for Stem Cell Training

Three-year grant from California Institute for Regenerative Medicine will bring six new postdoctoral fellows to the Buck

Press Release . Sep 15, 2009

“Anti-Atkins” Low Protein Diet Extends Lifespan in Flies

Diet boosts mitochondrial function, has implications for humans

Press Release . Jul 15, 2009

DNA Damaged Cells Communicate with Neighbors to Let them Know They’re in Trouble

Buck Institute research has implications in aging and cancer

Press Release . Jun 15, 2009

NIH supports Buck Institute’s Innovative Alzheimer’s Research with $1.6 Million “EUREKA” Grant

The highly competitive grant was awarded to Buck faculty member and founding CEO Dale Bredesen, MD...

Press Release . May 15, 2009

Buck Scientists Identify a Key Protein That May Explain the Anti-Aging and Anti-Cancer Benefits of Dietary Restriction

The finding provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.

Press Release . Apr 15, 2009

Sean Mooney, PhD, Joins Buck Faculty

Appointment highlights emphasis on bioinformatics and collaborative research

Press Release . Nov 25, 2008

Escape Cancer, But Age Sooner?

Buck Institute scientists unravel the dark side of the tumor suppressing process

Press Release . Sep 30, 2008

Buck Institute Study Shows Mixed Results for Life-Extending Properties of Antioxidants

Findings underscore need for consumer caution when taking supplements

Press Release . Jul 14, 2008

Buck Institute Receives $1.5 Million from Keck Foundation to Study Aging As Causal Factor for Disease

The research from Julie Andersen, PhD and Brad Gibson, PhD will bring together the disciplines of neuroscience, mitochondrial proteomics, functional bioenergetics and the biology of aging to test an idea that is likely to influence the way the biomedical community views research on age-related disease.

Press Release . Jun 10, 2008

Martin Brand, PhD, Joins Buck Faculty

Appointment establishes Institute’s research focus on diabetes

Press Release . May 16, 2008

Growth Factor Promotes New Neuron Growth in Mouse Model of Parkinson’s Disease

Mice induced to develop Parkinson’s disease (PD) show an increase in the growth of new neurons after they are treated with a well known growth factor...

Press Release . May 07, 2008

Buck Institute Receives $20.5 Million for New Stem Cell Building

The CIRM award would provide seed money for the institute’s second research facility...

Press Release . Apr 21, 2008

Victoria Lunyak, PhD, Joins Buck Faculty

Appointment establishes program in epigenetics and aging

Press Release . Mar 07, 2008

Paradoxical Alzheimer’s Finding May Shed New Light on Memory Loss

The study provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD.

Press Release . Feb 25, 2008

Buck Institute Announces Senior Management Change

Dale Bredesen, MD, will discontinue his duties as CEO to spend more time on a private start-up health promotion and disease prevention company that he recently co-founded...

news . Feb 20, 2008

Buck Research Focuses on Risk Factor for Parkinson’s Disease

Study suggests preventive treatment may be useful for those who have high levels of particular enzyme that regulates nerve activity in the brain

Press Release . Dec 19, 2007

Glutathione Depletion Leads to Symptoms of Parkinson’s Disease in Mice

Buck Institute study provides new model for the study of the neurodegenerative disease while highlighting the role of aging in disease development

Press Release . Oct 10, 2007

Drug Commonly Used to Treat Bi-Polar Disorder Dramatically Increases Lifespan in Nematode Worms

Press Release . Sep 06, 2007

Buck Institute Awarded $25 Million to Establish New Scientific Discipline of Geroscience

Press Release . Jun 26, 2007

Combined Exposure to Environmental Toxics Accelerates Age-Related Development of Parkinson’s Disease in Mice

Buck Institute study highlights the role of environmental factors in the most common form of the neurodegenerative disease

Press Release . Jun 05, 2007

Buck Institute Awarded $4.1 Million for Shared Research and Laboratory and Training Facility for Human Embryonic Stem Cell Research

Press Release . May 28, 2007

Exercise Reverses Aging in Human Skeletal Muscle

Buck Institute faculty lead study showing “genetic fingerprints” becoming younger in healthy seniors who did resistance training

Press Release . May 10, 2007

Landmark Study Identifies a Large Number of New Proteins Implicated in Huntington’s Disease

Buck Institute faculty leads large scale screening of protein interactions to identify drug targets for possible treatment of incurable neurodegenerative disease

Press Release . Jan 22, 2007

Unprecedented Screening of Up to 120,000 Chemical Compounds for Lifespan Extension to Begin

Grant establishes “Hillblom Chemical Biology of Aging Network” at Buck Institute for Age Research

Press Release . Nov 08, 2006

Overexpression of Human Protein Reduces Severity of Alzheimer’s Disease in Mice

Ultimate goal of research is to identify drugs which boost the body’s attempt to heal itself

Press Release . Nov 02, 2006

Buck Institute Study Finds Inflammation is a Culprit in Nerve Death in Mouse Model of Parkinson’s Disease

Discovery offers new model to explore anti-inflammatory treatments for progressive, incurable neurodegenerative disease

Press Release . Aug 21, 2006

Buck Institute Study Shows Newborn Neurons May Promote Stroke Recovery in Humans

Press Release . Jun 15, 2006

Is it Time to Reexamine Iron Content in Infant Formula?

Neonatal mice fed the equivalent amount of iron used in human infant formula develop Parkinson’s-like neurodegeneration as they age

Press Release . Jun 01, 2006

Proteins Linked to Cancer Prevention in Humans Affect Aging in Worms

Discovery opens a new avenue of inquiry into aging as a risk factor for cancer

Press Release . Apr 24, 2006

Buck Study Provides a Startling New Look at Alzheimer’s

Mouse brains look like Alzheimer’s, but mouse memories do just fine

Press Release . Nov 28, 2005

Growth Factor Promotes New Neuron Growth and Increased Survival in Mice with Huntington’s Disease

Buck Institute study shows potential for new avenue of treatment for incurable, hereditary brain disorder

Press Release . Sep 28, 2004

“Fruit Fly” Researcher Joins Buck Institute

Other Adjunct Appointments Mark 5-year Anniversary

Press Release . Sep 02, 2004

Buck Scientists Identify “Jekyll-Hyde” Cancer Gene

New Finding Challenges Traditional View of Cancer Genes

Press Release . Dec 01, 2003

Buck Institute Study Shows Birth of New Nerve Cells Increased in Patients with Alzheimer’s Disease

Stimulating Neurogenesis May Provide New Treatment Strategies

Here’s what’s happening

Upcoming events at the Buck

Service Animal Accommodation

Ongoing

Formal Research Seminars

FRS talks are being held via Zoom by invitation only.

See all events

Buck Institute @BuckInstitute·

Another shout out for #metformin! In studies in mice the common diabetes drug (which may slow aging) shows promise as a treatment for COVID-19 lung inflammation. Metformin inhibited IL-1B and inflammasome assembly in immune cells found in the lungs.
https://www.eurekalert.org/pub_releases/2021-06/uoc--cdd060821.php

Buck Institute @BuckInstitute·

Meet our scientists! Brazilian postdoc @su_benitez models Alzheimer`s in flies & found specific signaling pathway which is over-activated. Preliminary experiments show same over-activation happens in mice with Alzheimer`s. She's now testing a drug that modulates this pathway.

Buck Institute @BuckInstitute·

Thank you, #nakedmolerat paper. We needed you to make it through the rest of the week! Nice summary of of what we know so far about these remarkable creatures coming from @UniofBradford https://www.eurekalert.org/pub_releases/2021-06/uob-cnm061021.php

The Oxford Character Project @OxfordCharacter·

In our GLI #mentor appreciation post this week we thank Prof. Julie Anderson of @BuckInstitute & Prof. Yuli Tamir of @shenkar_m for their generosity with their time. Thank you for imparting your wisdom to our students!

#global #leadership #initiative #gli2021 #studentdevelopment

Buck Institute @BuckInstitute·

Learning a new language, or how to play the guitar? Give yourself a break – at least a short one! A study from #NIH shows that breaks may help our brains learn new skills. https://www.nih.gov/news-events/news-releases/study-shows-how-taking-short-breaks-may-help-our-brains-learn-new-skills