News . Jun 10, 2025 The same technology that enables targeted immunotherapy for cancer could be used to tackle Alzheimer’s Proof-of-concept study shows CAR cells can detect both tau tangles and various forms of amyloid plaques Read more
News . Jun 04, 2025 A New Blood-Based Epigenetic Clock for Aging Focuses on Intrinsic Capacity New tool provides a path for a scalable, cost-effective way to assess functional decline and could help end the argument over whether aging should be categorized as a disease. Read more
News . May 28, 2025 Clinical Trial and Multi-omics Analysis Demonstrates the Impact of Therapeutic Plasma Exchange on Biological Age Study in Aging Cell shows that therapeutic plasma exchange combined with intravenous immunoglobulin reduced biological age on average by 2... Read more
News . May 12, 2025 Buck Institute Team is Named Semifinalist of XPRIZE Healthspan $101 Million Global Competition Aims to Revolutionize How We Approach Aging Read more
News . Dec 19, 2024 Buck Institute and Phenome Health Awarded up to $52M from ARPA-H Award Aims to Transform Healthcare with Personalized Analytics Read more
News . Dec 02, 2024 Ketone bodies: more than energy, they are powerful signaling metabolites that clean up damaged proteins Read more
News . Oct 29, 2024 Crunching fruit fly and human data via machine learning reveals key metabolites that impact lifespan in both species Read more
News . Jul 09, 2024 Health AI Expert Nathan Price Joins Buck Faculty Price will also co-direct the Center for Human Healthspan Read more
News . Jun 11, 2024 Buck researchers explore how the immune system goes awry during space travel and the implications for human aging on Earth Findings provide insight into interventions to maintain normal immunity in space and during aging on the ground Read more
News . Jun 06, 2024 Buck Institute and Sens.ai Collaborate to Study Brain Aging New Longevity Tech Collaboration Will Research and Develop First-Ever Biological Clock for the Brain Read more
News . May 16, 2024 The Vicious Cycle of Protein Clumping in Alzheimer’s Disease and Normal Aging Buck researchers uncover connections and suggestions for interventions to improve both Read more
News . May 08, 2024 Hevolution Foundation funds promising pre-clinical studies at the Buck Institute Buck Assistant Professor John Newman, MD, PhD, received more than $2... Read more
News . Mar 28, 2024 Buck-Founded Aeovian Pharmaceuticals doses first participants in Phase I trial Aeovian also raises $50M to advance novel science Read more
News . Feb 01, 2024 Buck Scientists Discover a Potential Way to Repair Synapses Damaged in Alzheimer’s Disease Boosting the KIBRA protein reversed memory impairment in mouse model of Alzhheimer’s despite the presence of toxic tau. Read more
News . Jan 22, 2024 The Buck Institute mourns the death of Judy Campisi The pioneering, internationally celebrated researcher was known for her work in cellular senescence and aging Read more
News . Jan 11, 2024 Buck Scientists Identify How Dietary Restriction Slows Brain Aging & Increases Lifespan The mechanism provides potential therapeutic targets to slow aging and age-related neurodegenerative diseases Read more
News . Jan 03, 2024 New roles for autophagy genes in cellular waste management and aging Autophagy genes help extrude protein aggregates from neurons in the nematode C... Read more
News . Nov 30, 2023 Buck Institute Receives $21 Million Hevolution Foundation Grant Multi-year Partnership Targeting Therapeutic Interventions in Aging Read more
News . Nov 10, 2023 New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells Buck researchers identify new pathway for mitophagy which highlights the gut/brain connection Read more
News . Oct 17, 2023 Buck Researchers Uncover Mechanism That Links NAD+ to Fertility Problems More than a fertility study, the findings can help understand female aging in general Read more
News . Sep 27, 2023 The Buck Institute and Phenome Health Announce Major Strategic Partnership Famed Scientist Lee Hood will co-direct the Center for Phenomic Health at the Buck Read more
News . Sep 11, 2023 The Buck gets $3.5 million to conduct the first-ever clinical trial of ketone supplementation to treat and or prevent frailty NIH grant funds TAKEOFF, a multi-site clinical trial to determine if putting at-risk older adults into ketosis can stave off a key aspect of geriatric syndrome Read more
News . Jul 07, 2023 First bioavailable compound that specifically inhibits free radical production in mitochondria prevents and treats metabolic syndrome in mice A potential therapeutic for one of the major chronic diseases of aging Read more
News . May 15, 2023 NIH Renews Training Grant for $3.9 Million Administered by the Buck Institute, the T32 program has trained 110 postdoctoral scientists over the past 25 years... Read more
News . Mar 28, 2023 Retinal scans: A non-invasive, inexpensive method to track human aging Pankaj Kapahi and Kenny Wilson publish a study in eLife that supports the notion that the eye is a “window to aging”. Read more
News . Jan 23, 2023 The Buck Institute Launches First Human Clinical Trial Effort marks the first study of ketone body supplementation in healthy older adults; participants will be recruited in Marin County Read more
News . Dec 02, 2022 Brain aging is not one-size-fit-all: Chronological age, biological age and gender affect the shrinkage of different brain areas. "This work breaks open the black box between aging and neurodegeneration”: Buck Institute associate professor David Furman Read more
Press Release . Oct 04, 2022 High Risk/High Reward Grant Funds Development of Smart Drug Delivery System to Treat Multiple Alzheimer’s Pathologies The Buck’s $2.4 million Transformative Research Award is one of just nine in the nation Read more
Press Release . Aug 16, 2022 Buck Scientists Highlight New Perspective in How Immunity is Fine-Tuned through Mechanics Introducing a new scientific discipline: Mechanoimmunlogy Read more
Press Release . Aug 16, 2022 Buck Institute scientists uncover a new role for blood-brain barrier in neuron function and damage Findings open up a potential new avenue for therapies aimed at countering neurodegeneration Read more
Press Release . Jun 07, 2022 Buck researchers uncover intriguing connection between diet, eye health and lifespan Buck researchers uncover an intriguing connection between diet, eye health and lifespan in Drosophila Read more
Press Release . May 18, 2022 Buck Scientist Uncovers Clues to Aging in Mitochondria Understanding how the process starts can point to new directions in aging research Read more
Press Release . Feb 02, 2022 A naturally-occurring metabolite is a potent senolytic in both mice and human cell culture 25-hydroxycholesteral shows particular efficacy in skeletal muscle Read more
Press Release . Jan 20, 2022 New findings for the function of tau in neurodegenerative disease Cutting-edge proteomics enables the mapping of the “tau interactome” Read more
Press Release . Dec 15, 2021 Forever Healthy and the Buck Institute Announce Partnership to Advance Translational Research in Human Rejuvenation Michael Greve's Forever Healthy Foundation commits $5 million to fund breakthrough science with strong potential for startup creation at the Buck. Read more
Press Release . Nov 16, 2021 Four Buck professors recognized as among most highly cited researchers in the world Listing is based on the publication of multiple highly cited research papers. Read more
Press Release . Oct 19, 2021 Buck Institute awarded $12.7 million from NIH to join SenNet, Cellular Senescence Network Buck scientists will identify and characterize senescent cells - recognized as a driver of age-related disease - in human ovaries, breast tissue and skeletal muscle Read more
Press Release . Oct 13, 2021 Astera Institute and Buck Institute announce $70 million collaboration to redefine the field of research on aging The Rejuvenome Project is a first of its kind study seeking to fully characterize aging and validate optimal longevity intervention combinations for extending lifespan Read more
Press Release . Sep 29, 2021 Buck Institute awarded $14 million from NIH to study cellular senescence and Alzheimer’s Focusing on one of the major drivers of aging brings a new approach to Alzheimer’s and dementia research Read more
Press Release . Sep 22, 2021 Buck researchers provide a framework to study precision nutrigeroscience In calling for a personalized approach to diet, a new research sub-specialty deals with the fact that health benefits from many forms of dietary restriction vary and are not “one size fits all” Read more
Press Release . Sep 07, 2021 Aging: It’s more complicated than we thought Buck researchers make surprising discovery about the connection between protein shape and mitochondrial health Read more
Press Release . Jul 21, 2021 Unexpected proteome plasticity in response to persistent temperature rise Study in budding yeast brings molecular biology to climate change Read more
Press Release . Jul 12, 2021 First actionable clock that predicts immunological health and chronic diseases of aging Research highlights the critical role of the immune system in the aging process Read more
Press Release . Jun 01, 2021 Huntington’s disease: Modulating rapamycin target protein FKBP51 pathway promotes autophagy, lowering Huntingtin protein Experiments with small molecule has implications for research on aging. Read more
Press Release . Mar 09, 2021 A new predictive model helps identify those at risk for severe COVID-19 Buck scientists analyze data from 3 million people using a smartphone app in the United Kingdom Read more
Press Release . Jan 26, 2021 A compound that slows bone loss, and a resource for developing treatments to slow aging Longitudinal and functional study of 700 aging mice provides a treasure trove of data for those studying aging and age-related diseases Read more
Press Release . Jan 12, 2021 Tissue stiffness likely drives immune responses in many chronic diseases Buck research points to the possibility of new immunotherapeutics and highlights critically needed changes in experimental techniques Read more
Press Release . Dec 16, 2020 Buck Institute Names Malene Hansen as Chief Scientific Officer Dr. Malene Hansen is joining the Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission” Read more
Press Release . Nov 16, 2020 Chronic inflammation causes a reduction in NAD+ Buck research links hallmarks of aging: senescent cells activate CD38 which degrades NAD+, a key metabolite implicated in age-related decline Read more
Press Release . Sep 01, 2020 A metabolite produced by the body increases lifespan and dramatically compresses late-life morbidity in mice Alpha-ketaglutarate improves several measures of healthspan in double-blind study Read more
Press Release . Aug 10, 2020 Global Consortium for Reproductive Longevity & Equality Announces First Grant Recipients 22 Researchers Selected to Receive $7... Read more
Press Release . Jul 16, 2020 USC Leonard Davis School of Gerontology and The Buck Institute for Research on Aging Win $4.6 Million NIA Grant Prestigious award establishes the USC-Buck Nathan Shock Center of Excellence in the Basic Biology of Aging. Read more
Press Release . Jul 15, 2020 Researchers outline strategy for testing ketone bodies against COVID-19, other respiratory infections Review in Med highlights the role of geroscience in the fight against this and future pandemics. Read more
Press Release . Jun 22, 2020 New tools will enhance the specificity of imaging in the mouse brain Researchers image neural circuits by targeting the cell body using ribosome tethering Read more
Press Release . Jun 03, 2020 Eat less and live a long healthy life? Study shows “not in all cases” Results from research involving 160 genetically distinct strains of fruit flies give insight into what will likely happen in humans using dietary restriction to add extra years (and extra health) to life. Read more
Press Release . Jan 29, 2020 Buck researchers discover how cellular senescence leads to neurodegeneration Findings available to scientists studying both dementia and brain cancer. Read more
Press Release . Jan 16, 2020 Stage is set to develop clinically relevant, senescence-based biomarkers of aging Proteomic Atlas of Senescence-Associated Secretomes can be used by the research community to speed translation of therapeutics to clinical use Read more
Press Release . Oct 31, 2019 Experts call on the World Health Organization, governments and medical communities to develop common classifications and systems to diagnose and treat age-related diseases. An international team of researchers have put forward a position statement, published in Science, which lays out a new healthcare framework to help aging populations stay healthier for longer... Read more
Press Release . Oct 01, 2019 The Buck gets $3.8 M Transformative Research Award from the NIH A mouse that can regrow axons after brain injury is the focus of a new method to pinpoint genetic differences between species Read more
Press Release . Sep 30, 2019 The Bia-Echo Foundation announces the Global Consortium for Reproductive Longevity and Equality in partnership with the Buck Institute The Consortium will award $7... Read more
Press Release . Sep 24, 2019 Cellular senescence is associated with age-related blood clots Publishing in the September 24 edition of Cell Reports, researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots... Read more
Press Release . Aug 15, 2019 Uric acid pathologies shorten lifespan in flies, highlighting the need for screening in humans Backed by human genetics, research in flies provides potential drug targets for gout, metabolic syndrome, diabetes and kidney stones Read more
Press Release . Jun 17, 2019 The Buck announces first faculty appointments for the Center for Female Reproductive Longevity and Equality Lei Lei, PhD, Shiying Jin, PhD, Francesca Duncan, PhD, and Jennifer Garrison, PhD are the first faculty members to join the Buck Institute’s Center for Female Reproductive Longevity and Equality. Read more
Press Release . May 31, 2019 Buck professor Gordon Lithgow receives prestigious award from the American Aging Association Denham Harman Award recognizes lifetime achievement in research on aging Read more
Press Release . Apr 17, 2019 Buck Professor Emeritus David Nicholls elected to the Royal Society Read more
Press Release . Feb 14, 2019 Buck faculty help found Academy for Health and Lifespan Research A group of the world’s leading scientists form nonprofit aimed at accelerating breakthroughs to extend human healthspan. Read more
Press Release . Feb 12, 2019 Intervening in glial cells protects neurons in Parkinson’s model Buck researchers identify crosstalk between dopaminergic neurons and glial cells in fruit flies providing a potential new target for preventative treatment. Read more
Press Release . Jan 15, 2019 MANF identified as a rejuvenating factor in parabiosis Buck researchers also harness an innate repair mechanism to protect against liver damage in aging mice and extend lifespan in flies... Read more
Press Release . Nov 06, 2018 Does dietary restriction protect against age-related leaky gut? Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract... Read more
Press Release . Oct 08, 2018 A new method to pinpoint genetic differences between species Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms... Read more
Press Release . Aug 28, 2018 Tara Tracy joins faculty at Buck Institute Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s Read more
Press Release . Aug 14, 2018 Three leaders in longevity biotechnology form a research collaboration The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics Read more
Press Release . Jul 25, 2018 World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's... Read more
Press Release . Jul 09, 2018 First patient treated with drug based on Buck research Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial Read more
Press Release . May 01, 2018 Buck Institute Faculty Member Elected to the National Academy of Sciences Read more
Press Release . Apr 05, 2018 Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project. Read more
Press Release . Mar 13, 2018 Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice. Read more
Press Release . Jan 23, 2018 A Potential New Therapeutic Approach for Parkinson’s Disease A potential new therapeutic approach for Parkinson’s disease. Read more
Press Release . Dec 07, 2017 Inhibiting TOR boosts regenerative potential of adult tissues Rapamycin prevents age-related loss of stem cells Read more
Press Release . Nov 20, 2017 Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research The funding will Dr. Lisa Ellerby's work in Huntington's disease Read more
News . Oct 05, 2017 Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant Chuankai Zhou is awarded prestigious Early Independence Award from NIH Read more
Press Release . Sep 05, 2017 Ketogenic diet improves healthspan and memory in aging mice Study on the effects of ketone bodies opens up new area of inquiry in research on aging. Read more
Press Release . Aug 29, 2017 Some women with history of preeclampsia have significantly lower risk for breast cancer Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant Read more
Press Release . May 04, 2017 Large data set brings precision to breast cancer diagnosis and care Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence Read more
Press Release . Feb 21, 2017 Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity Read more
Press Release . Feb 06, 2017 Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease Buck Institute research leads to clinical trial for cystinuria at UCSF Read more
Press Release . Jan 17, 2017 Senescence promotes chemotherapy side effects and cancer relapse Eliminating pro-inflammatory cells after treatment relieves symptoms in mice. Read more
Press Release . Jan 12, 2017 Improving the longevity of functionally integrated stem cells in regenerative vision therapy Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells Read more
Press Release . Jan 04, 2017 Real Estate Entrepreneur Bill Poland Chairs Buck Institute Board of Trustees Prominent San Francisco commercial real estate developer Bill R... Read more
Press Release . Dec 13, 2016 Research in worms provides a model to study how the microbiome influences disease in humans The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity Read more
Press Release . Dec 01, 2016 Buck Institute study provides neuronal mechanism for the benefits of fasting The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function Read more
Press Release . Nov 18, 2016 BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO Read more
Press Release . Oct 28, 2016 Buck Institute Appoints Edward Lanphier President and CEO The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer Read more
Press Release . Oct 18, 2016 Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J... Read more
Press Release . Oct 18, 2016 A new look at vitamin D challenges the current view of its benefits Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases Read more
Press Release . Oct 13, 2016 Research in worms provides path to study diabetic complications Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems Read more
Press Release . Oct 13, 2016 Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty... Read more
Press Release . Sep 15, 2016 Future therapeutics: drugs that stop free radicals at their source Research at the Buck Institute yields molecules that prevent free radical production by cells Read more
Press Release . Aug 24, 2016 Buck faculty Jennifer Garrison, PhD, receives prestigious $2.5 million award from NIH Five-year MIRA grant supports lab-based research on neuropeptide signaling Read more
Press Release . Jul 28, 2016 Buck Institute study sheds light on gender differences in diabetes and aging All’s not fair in love and glucose intolerance Read more
Press Release . Jul 06, 2016 Improving on a broccoli-related compound yields a possible treatment for macular degeneration Buck Institute study also shows that palmitoleic acid protects the retina from environmental damage in mouse models of disease. Read more
Press Release . Jul 05, 2016 Metformin as a potential treatment for a rare pediatric disorder Study in human skin cells and mice shows widely-used diabetes drug reduces toxic acid levels in Maple Syrup Urine Disease Read more
Press Release . Jun 15, 2016 Pre and post testing show reversal of memory loss from Alzheimer’s disease in ten patients Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders Read more
Press Release . Jun 01, 2016 Buck researchers identify new “druggable” target for sporadic Parkinson’s disease Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson’s disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally... Read more
Press Release . May 26, 2016 Can we extend healthspan by altering the perception of food? Tricking C elegans into a state of caloric restriction extends lifespan by 50% and suggests new targets for human pharmacology Read more
Press Release . May 17, 2016 Buck research may provide missing link in search for Parkinson’s disease therapeutics Largest collection of induced pluripotent stem cell lines and related genomic assays from Parkinson’s patients provide a disease model which will be available to researchers world-wide Read more
Press Release . Mar 23, 2016 The Glenn Center for Biology of Aging Research Established at the Buck Institute It is increasingly clear that inter-connected mechanisms drive age-related disease... Read more
Press Release . Feb 10, 2016 A new method furthers understanding of evolutionary genetics Publishing in Nature Genetics, discovery helps unravel the mystery of ancient traits Read more
Press Release . Feb 10, 2016 Inhibiting age-related inflammation maintains healthy gut microbiota and extends lifespan Blocking a well-known inflammatory pathway in the fly prevents abnormal changes in gut tissue, benefits gut bacteria and delays functional decline associated with age Read more
Press Release . Feb 03, 2016 Buck Institute for Research on Aging Supports Launch of Incubator Company Focused on Age-Related Diseases Unity Biotechnology First Company to Focus on Translating Science of Senescence to Medicines Designed to Increase Healthspan San Francisco/Novato, Calif - February 3, 2016 Based on research pioneered by Buck Institute faculty Judith Campisi, Ph... Read more
Press Release . Jan 22, 2016 The connection between excess iron and Parkinson’s disease Excess iron impairs cellular recycling resulting in toxic oxidative stress Read more
Press Release . Jan 13, 2016 A surprising new role for ApoE offers explanation for its diverse range of effects, particularly in Alzheimer’s Buck Institute/UCLA study finds that apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes... Read more
Press Release . Dec 10, 2015 Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology Read more
Press Release . Nov 30, 2015 Intracellular calcium integrates complex signaling to control stem cell activity Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation Read more
Press Release . Nov 18, 2015 Dietary restriction gives fruit flies a rhythm for a long life Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development Read more
Press Release . Oct 22, 2015 $1.25 million bequest funds first named professorship at Buck Institute Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1... Read more
Press Release . Oct 16, 2015 Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field. Read more
Press Release . Oct 13, 2015 Buck Faculty Jennifer Garrison Announced as an Allen Institute for Brain Science 2015 Next Generation Leader Assistant professor Jennifer Garrison, PhD, has been selected as one of this year’s six Next Generation Leaders at the Allen Institute for Brain Science... Read more
Press Release . Oct 05, 2015 Mapping the Genes that Increase Lifespan Comprehensive study finds 238 genes that affect aging in yeast cells. Read more
Press Release . Jul 29, 2015 Surprising results in study of mitochondrial dysfunction in skin casts light on the free radical theory of aging Scientists in the Campisi lab at the Buck Institute bred mice that produced excess free radicals that damaged the mitochondria in their skin Read more
Press Release . Jul 28, 2015 An imbalance of cellular bioenergetics in pancreatic beta-cells is linked to type 2 diabetes Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes... Read more
Press Release . Jul 24, 2015 Low-dose lithium reduces side effects from most common treatment for Parkinson’s disease Buck Institute research provides further validation that low-dose lithium could be repurposed as a therapy for the incurable neurodegenerative disorder Read more
Press Release . Jun 20, 2015 New paradigm for treating “inflammaging” and cancer Intermittent dosing with rapamycin breaks inflammatory loop that fuels tumor relapse and age-related diseases Read more
Press Release . Jun 04, 2015 Serotonin receptor is involved in eczema and other itch conditions Dermatologists have long known that available treatments for chronic itch, including eczema, are simply not up to scratch... Read more
Press Release . May 25, 2015 Complex signaling between blood and stem cells controls regeneration in fly gut Buck Institute scientists say impaired interactions between macrophages and stem cells are likely players in human intestinal maladies like IBS, leaky gut and colorectal cancers Read more
Press Release . Apr 28, 2015 Calico enters into agreement with the Buck Institute to conduct research into the biology of aging and to identify potential therapeutics for age-related diseases Calico, a company focused on aging research and therapeutics, and the Buck Institute for Research on Aging have partnered to support research into longevity and age-related diseases... Read more
Press Release . Feb 09, 2015 Mechanistic finding may provide a means to deal with side effects of lifespan-extending drug rapamycin Rapamycin, an FDA-approved drug, extends lifespan in mice up to 30% Read more
Press Release . Jan 21, 2015 Buck Institute faculty Judith Campisi receives first Olav Thon Foundation Prize Norway’s largest charitable foundation bestows cash prize for Campisi’s pioneering work on cancer and aging Read more
Press Release . Jan 15, 2015 Is there a connection between heavy metals and aging? Study in C. elegans shows excess iron promotes aging Read more
Press Release . Dec 16, 2014 Low-dose lithium prevents Parkinson’s symptoms in aged mice with a human mutation for the disease Study provides further validation that lithium could be repurposed as a therapy for the incurable neurodegenerative disorder Read more
Press Release . Dec 14, 2014 Senescent cells play an essential role in wound healing Study highlights ability to avoid a potential side effect of healthspan extending drugs Read more
Press Release . Dec 11, 2014 Could ibuprofen be an anti-aging medicine? Study shows popular over-the counter drug extends lifespan in yeast, worms and flies Read more
Press Release . Nov 15, 2014 Buck Faculty Henri Jasper, PhD, Receives Prestigious BIG Award Buck faculty Henri Jasper, PhD, gets prestigious “Breakthroughs in Gerontology” award from the Glenn Foundation and the American Federation for Aging Research Read more
Press Release . Nov 06, 2014 Leading scientists identify research strategy for highly intertwined “pillars of aging” Leading scientists identify research strategy for highly intertwined “pillars of aging” as next step in supporting the trans-NIH Geroscience Interest Group’s efforts to integrate aging into research on chronic diseases Read more
Press Release . Sep 29, 2014 Memory loss associated with Alzheimer’s reversed for first time In a novel, personalized and comprehensive program to reverse memory loss, nine of 10 participants displayed subjective or objective improvement in their memories Read more
Press Release . Aug 07, 2014 Researchers propose “disruptive” new system to reclassify tumors Largest cancer genomic study proposes “disruptive” new system to reclassify tumors Read more
Press Release . Mar 06, 2014 Rachel Brem, PhD, Joins Buck Institute Faculty Associate Professor studies naturally-occurring genetic variations that impact characteristics of aging Read more
Press Release . Mar 04, 2014 Buck Institute Mourns Death of Catherine Munson, Long-Time Trustee and former Board Chair Iconic Realtor was Community Activist and Philanthropist Read more
Press Release . Feb 26, 2014 New at the Buck: Huntington disease protein network Researchers at the Buck Institute have identified and categorized thousands of protein interactions involving huntingtin, the protein responsible for Huntington’s disease (HD)... Read more
Press Release . Feb 18, 2014 Buck faculty Jennifer Garrison, PhD, Named 2014 Sloan Research Fellow by the Alfred P. Sloan Foundation Buck Assistant Professor Jennifer Garrison, PhD, has been awarded a prestigious Sloan Research Fellowship Read more
Press Release . Jan 09, 2014 Altering Community of Gut Bacteria Promotes Health and Increases Lifespan Study provides first systemic understanding of aging gut Read more
Press Release . Dec 12, 2013 Five-Fold Lifespan Extension in C. Elegans by Combining Mutants Research Highlights Possibility of Combination Therapy for Aging Read more
Press Release . Nov 20, 2013 Aging Impacts Epigenome in Human Skeletal Muscle Buck Institute research involves first genome-wide DNA methylation study in disease-free tissue Read more
Press Release . Nov 20, 2013 The Buck Institute for Research on Aging and the University of Southern California Launch the Nation’s First PhD Program in the Biology of Aging Program is a Landmark in the History of the Buck Read more
Press Release . Oct 21, 2013 Major Alzheimer’s Risk Factor Linked to Red Wine Target Buck Institute study provides insight for new therapeutics that target the interaction between ApoE4 and a Sirtuin protein Read more
Press Release . Oct 14, 2013 Research in Aging Fruit Flies May Explain the Roots of Metabolic Dysfunction in Aging Humans Findings provide a rationale for "Why We Just Can’t Eat What We Used To" Read more
Press Release . Sep 10, 2013 Buck Institute Adds Two New Faculty Their research focuses on very different realms of the nervous system Read more
Press Release . Jun 26, 2013 Research in Fruit Flies Provides New Insight into Barrett’s Esophagus A new study suggests a change in stem cell function causes cells in lower esophagus to transform into stomach-like cells Read more
Press Release . Jun 17, 2013 Buck Faculty Receives Prestigious Tenovus Award Buck faculty Gordon Lithgow, PhD, has received the prestigious 2013 Tenovus-Scotland Medal Read more
Press Release . Jun 10, 2013 Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice Rapamycin is already FDA approved for other indications Read more
Press Release . Apr 21, 2013 CDI Partners with Buck to Derive and Bank iPSCs Cellular Dynamics International Opens Facility in California, Leasing Space from the Buck Institute to Derive and Bank Human Induced Pluripotent Stem Cells Read more
Press Release . Nov 29, 2012 Buck Scientists Publish Genome-Scale Study Identifying Hundreds of Potential Drug Targets for Huntington’s Disease Scientists searching for ways to develop treatments for Huntington’s disease (HD) just got a roadmap that could dramatically speed their discovery process Read more
Press Release . Nov 01, 2012 Arthur and Drue Gensler Donate $5 Million to Buck Institute Gift from Board Member and Architectural Visionary Will be Honored by the Naming of Administrative Building Read more
Press Release . Oct 25, 2012 Buck Institute Announces its Founding Partnership with Delos Pharmaceuticals New Company is Developing Therapeutics for Age-Associated Disease Read more
Press Release . Sep 22, 2012 Buck Institute and UC Santa Cruz Collaborators Make Significant Contribution to Landmark Breast Cancer Study TCGA study demonstrates existence of four main classes of breast cancer; Buck collaboration points to similarities between a type of breast and ovarian cancer Read more
Press Release . Sep 06, 2012 Stem Cell Agency Awards Buck Faculty $1.5 Million to Make 3-D Model of the Retina Efforts to understand and treat degenerative eye diseases utilizing stem cell technology just got a boost Read more
Press Release . Jul 25, 2012 Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction FDA-approved drug improves cardiac and skeletal muscle function and extends lifespan Read more
Press Release . Jul 02, 2012 Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process Read more
Press Release . Jun 28, 2012 Buck Scientists Correct Huntington’s Disease Mutation in Induced Pluripotent Stem Cells Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington’s disease (HD) using a human induced pluripotent stem cell Read more
Press Release . Jun 15, 2012 Glenn Foundation Awards Buck Institute $1 Million to Establish Training Fellowships in the Biology of Aging The monies will bring new postdoctoral fellows to the Buck Institute, funding two years of research for each of 10 scientists Read more
Press Release . May 21, 2012 Modifying Scar Tissue Can Potentially Improve Outcome in Chronic Stroke Buck Institute animal study builds on spinal cord injury research Read more
Press Release . Apr 12, 2012 New Regenerative Medicine Research Center to Open at Buck Institute Public Invited to April 14 Open House/Ribbon Cutting Read more
Press Release . Mar 28, 2012 Buck Institute Helps Launch National “Healthspan Campaign” Press Event in Washington, DC is hosted by Alliance for Aging Research Read more
Press Release . Jan 31, 2012 Need an Excuse to Book a Massage? Research Shows it Reduces Inflammation and Promotes Growth of New Mitochondria Following Strenuous Exercise Massage reduces inflammation and promotes the growth of new mitochondria in skeletal muscle Read more
Press Release . Dec 20, 2011 Management Consultant, Community Leader James Edgar Elected to Chair Buck Institute Board of Trustees James M. Edgar, a life-long management consultant and community leader has been elected Chair of the Board of Trustees Read more
Press Release . Sep 27, 2011 Buck Institute Adds Two New Faculty Stem cell technologies will be utilized to study vision disorders and skeletal muscle physiology Read more
Press Release . Sep 19, 2011 Scientists Turn Back the Clock on Adult Stem Cells Aging Reversing the aging process could lead to medical treatments for many chronic conditions Read more
Press Release . Jun 30, 2011 Researchers Flip the Switch Between Aging and Development in C. elegans Buck Institute scientists note first observation of genome-wide shift kicked off at level of translation that extends lifespan Read more
Press Release . Jun 20, 2011 Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease Buck Institute research in mice moves into preclinical stage; Buck working toward human trial Read more
Press Release . Jun 01, 2011 John W. “Jack” Rowe Donates $1 Million to Buck Institute Gift from healthcare visionary who helped establish the Buck is announced at the kick-off event for the new Buck Advisory Council. Read more
Press Release . May 11, 2011 A New Role for Endocannabinoid Signaling in Dietary Restriction and Lifespan Extension Study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability Read more
Press Release . Mar 30, 2011 Common Laboratory Dye is a Wonder Drug — for Worms Study in Nature shows Basic Yellow 1 profoundly extends lifespan in healthy nematodes, and slows Alzheimer's disease-like pathology in worms Read more
Press Release . Feb 16, 2011 Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD Physician-Scientist was a Pioneer in Medical Genetics, Down Syndrome and Aging Research Read more
Press Release . Nov 04, 2010 Novel Method Results in Promising Drugs for Huntington’s Disease Therapeutics Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are underway in mice Read more
Press Release . Oct 21, 2010 Buck Institute Awarded $6 Million to Lead Effort to Get Stem Cell Treatment for Parkinson’s Disease Ready for Clinical Trials The Buck Institute for Age Research has been awarded $6 million from the California Institute for Regenerative Medicine to fund a three-year project aimed at getting a stem cell derived treatment for Parkinson's disease Read more
Press Release . Sep 07, 2010 A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response Buck Institute study says it’s about translation, not just transcription Read more
Press Release . Aug 16, 2010 Scientists Successfully Use Human Induced Pluripotent Stem Cells to Treat Parkinson’s Disease in Rodents Technologies developed at Buck Institute can speed the manufacturing of authentic neurons from stem cells for future clinical applications Read more
Press Release . Aug 16, 2010 Buck Institute Partners with BioMarin to Expand Early Research on Novel Treatment for Familial Alzheimer’s Disease The Buck Institute for Age Research announced that it has entered into a research collaboration with BioMarin Pharmaceutical Inc... Read more
Press Release . Jul 25, 2010 Leap Forward in Efforts to Develop Treatments for Huntington’s Disease Buck Institute scientists identify new targets for drug development, some of which already respond to cancer drugs Read more
Press Release . Jun 28, 2010 Brian K. Kennedy, PhD, Appointed as New CEO of Buck Institute for Age Research Kennedy, who has earned an international reputation for his work in the basic biology of aging, comes to the Buck Institute from the University of Washington in Seattle where he most recently served in the Department of Biochemistry Read more
Press Release . May 13, 2010 Fruit Flies Provide New Clues on How Organisms Make Dietary Choices Research at Buck Institute for Age Research opens the door for future treatments for metabolic and eating disorders Read more
Press Release . Apr 07, 2010 Buck Institute Study Suggests New Strategy for Treatment of Stroke Research in rodents highlights need for human clinical trials of antidepressants and other drugs shown to increase growth of new neurons Read more
Press Release . Feb 08, 2010 Comprehensive Study Using Bioinformatics Predicts the Molecular Causes of Many Genetic Diseases Research spearheaded at the Buck Institute results in a web-based tool available to other scientists Read more
Press Release . Dec 15, 2009 Buck Institute Awarded $1.5 Million for Stem Cell Training Three-year grant from California Institute for Regenerative Medicine will bring six new postdoctoral fellows to the Buck Read more
Press Release . Sep 15, 2009 “Anti-Atkins” Low Protein Diet Extends Lifespan in Flies Diet boosts mitochondrial function, has implications for humans Read more
Press Release . Jul 15, 2009 DNA Damaged Cells Communicate with Neighbors to Let them Know They’re in Trouble Buck Institute research has implications in aging and cancer Read more
Press Release . Jun 15, 2009 NIH supports Buck Institute’s Innovative Alzheimer’s Research with $1.6 Million “EUREKA” Grant The highly competitive grant was awarded to Buck faculty member and founding CEO Dale Bredesen, MD... Read more
Press Release . May 15, 2009 Buck Scientists Identify a Key Protein That May Explain the Anti-Aging and Anti-Cancer Benefits of Dietary Restriction The finding provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life. Read more
Press Release . Apr 15, 2009 Sean Mooney, PhD, Joins Buck Faculty Appointment highlights emphasis on bioinformatics and collaborative research Read more
Press Release . Nov 25, 2008 Escape Cancer, But Age Sooner? Buck Institute scientists unravel the dark side of the tumor suppressing process Read more
Press Release . Sep 30, 2008 Buck Institute Study Shows Mixed Results for Life-Extending Properties of Antioxidants Findings underscore need for consumer caution when taking supplements Read more
Press Release . Jul 14, 2008 Buck Institute Receives $1.5 Million from Keck Foundation to Study Aging As Causal Factor for Disease The research from Julie Andersen, PhD and Brad Gibson, PhD will bring together the disciplines of neuroscience, mitochondrial proteomics, functional bioenergetics and the biology of aging to test an idea that is likely to influence the way the biomedical community views research on age-related disease. Read more
Press Release . Jun 10, 2008 Martin Brand, PhD, Joins Buck Faculty Appointment establishes Institute’s research focus on diabetes Read more
Press Release . May 16, 2008 Growth Factor Promotes New Neuron Growth in Mouse Model of Parkinson’s Disease Mice induced to develop Parkinson’s disease (PD) show an increase in the growth of new neurons after they are treated with a well known growth factor... Read more
Press Release . May 07, 2008 Buck Institute Receives $20.5 Million for New Stem Cell Building The CIRM award would provide seed money for the institute’s second research facility... Read more
Press Release . Apr 21, 2008 Victoria Lunyak, PhD, Joins Buck Faculty Appointment establishes program in epigenetics and aging Read more
Press Release . Mar 07, 2008 Paradoxical Alzheimer’s Finding May Shed New Light on Memory Loss The study provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD. Read more
Press Release . Feb 25, 2008 Buck Institute Announces Senior Management Change Dale Bredesen, MD, will discontinue his duties as CEO to spend more time on a private start-up health promotion and disease prevention company that he recently co-founded... Read more
Press Release . Feb 20, 2008 Buck Research Focuses on Risk Factor for Parkinson’s Disease Study suggests preventive treatment may be useful for those who have high levels of particular enzyme that regulates nerve activity in the brain Read more
Press Release . Dec 19, 2007 Glutathione Depletion Leads to Symptoms of Parkinson’s Disease in Mice Buck Institute study provides new model for the study of the neurodegenerative disease while highlighting the role of aging in disease development Read more
Press Release . Oct 10, 2007 Drug Commonly Used to Treat Bi-Polar Disorder Dramatically Increases Lifespan in Nematode Worms Read more
Press Release . Sep 06, 2007 Buck Institute Awarded $25 Million to Establish New Scientific Discipline of Geroscience Read more
Press Release . Jun 26, 2007 Combined Exposure to Environmental Toxics Accelerates Age-Related Development of Parkinson’s Disease in Mice Buck Institute study highlights the role of environmental factors in the most common form of the neurodegenerative disease Read more
Press Release . Jun 05, 2007 Buck Institute Awarded $4.1 Million for Shared Research and Laboratory and Training Facility for Human Embryonic Stem Cell Research Read more
News . May 28, 2007 Exercise Reverses Aging in Human Skeletal Muscle Buck Institute faculty lead study showing “genetic fingerprints” becoming younger in healthy seniors who did resistance training Read more
Press Release . May 10, 2007 Landmark Study Identifies a Large Number of New Proteins Implicated in Huntington’s Disease Buck Institute faculty leads large scale screening of protein interactions to identify drug targets for possible treatment of incurable neurodegenerative disease Read more
Press Release . Jan 22, 2007 Unprecedented Screening of Up to 120,000 Chemical Compounds for Lifespan Extension to Begin Grant establishes “Hillblom Chemical Biology of Aging Network” at Buck Institute for Age Research Read more
Press Release . Nov 08, 2006 Overexpression of Human Protein Reduces Severity of Alzheimer’s Disease in Mice Ultimate goal of research is to identify drugs which boost the body’s attempt to heal itself Read more
Press Release . Nov 02, 2006 Buck Institute Study Finds Inflammation is a Culprit in Nerve Death in Mouse Model of Parkinson’s Disease Discovery offers new model to explore anti-inflammatory treatments for progressive, incurable neurodegenerative disease Read more
Press Release . Aug 21, 2006 Buck Institute Study Shows Newborn Neurons May Promote Stroke Recovery in Humans Read more
Press Release . Jun 15, 2006 Is it Time to Reexamine Iron Content in Infant Formula? Neonatal mice fed the equivalent amount of iron used in human infant formula develop Parkinson’s-like neurodegeneration as they age Read more
Press Release . Jun 01, 2006 Proteins Linked to Cancer Prevention in Humans Affect Aging in Worms Discovery opens a new avenue of inquiry into aging as a risk factor for cancer Read more
Press Release . Apr 24, 2006 Buck Study Provides a Startling New Look at Alzheimer’s Mouse brains look like Alzheimer’s, but mouse memories do just fine Read more
Press Release . Nov 28, 2005 Growth Factor Promotes New Neuron Growth and Increased Survival in Mice with Huntington’s Disease Buck Institute study shows potential for new avenue of treatment for incurable, hereditary brain disorder Read more
Press Release . Sep 28, 2004 “Fruit Fly” Researcher Joins Buck Institute Other Adjunct Appointments Mark 5-year Anniversary Read more
Press Release . Sep 02, 2004 Buck Scientists Identify “Jekyll-Hyde” Cancer Gene New Finding Challenges Traditional View of Cancer Genes Read more
Press Release . Dec 01, 2003 Buck Institute Study Shows Birth of New Nerve Cells Increased in Patients with Alzheimer’s Disease Stimulating Neurogenesis May Provide New Treatment Strategies Read more
