Press Releases

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Does dietary restriction protect against age-related leaky gut?

Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract...
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A new method to pinpoint genetic differences between species

Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms...
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Tara Tracy joins faculty at Buck Institute

Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s
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Three leaders in longevity biotechnology form a research collaboration

The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics
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World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging

A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's...
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First patient treated with drug based on Buck research

Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial
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Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials

Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project.
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Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty

Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice.
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A Potential New Therapeutic Approach for Parkinson’s Disease

A potential new therapeutic approach for Parkinson’s disease.
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Inhibiting TOR boosts regenerative potential of adult tissues

Rapamycin prevents age-related loss of stem cells
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Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research

The funding will Dr. Lisa Ellerby's work in Huntington's disease
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Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant

Chuankai Zhou is awarded prestigious Early Independence Award from NIH
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Some women with history of preeclampsia have significantly lower risk for breast cancer

Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant
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Large data set brings precision to breast cancer diagnosis and care

Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence
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Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project

The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity
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Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease

Buck Institute research leads to clinical trial for cystinuria at UCSF
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Senescence promotes chemotherapy side effects and cancer relapse

Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.
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Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells
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Research in worms provides a model to study how the microbiome influences disease in humans

The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity
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Buck Institute study provides neuronal mechanism for the benefits of fasting

The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function
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CEO of Buck Institute
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BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH

ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO
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Buck Institute Appoints Edward Lanphier President and CEO

The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer
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Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease

Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J...
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A new look at vitamin D challenges the current view of its benefits

Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases
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Research in worms provides path to study diabetic complications

Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems
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Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases

As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty...
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Future therapeutics: drugs that stop free radicals at their source

Research at the Buck Institute yields molecules that prevent free radical production by cells
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Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype

Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology
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Intracellular calcium integrates complex signaling to control stem cell activity

Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation
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Dietary restriction gives fruit flies a rhythm for a long life

Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development
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$1.25 million bequest funds first named professorship at Buck Institute

Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1...
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Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease

Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field.
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Buck Faculty Jennifer Garrison Announced as an Allen Institute for Brain Science 2015 Next Generation Leader

Assistant professor Jennifer Garrison, PhD, has been selected as one of this year’s six Next Generation Leaders at the Allen Institute for Brain Science...
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Mapping the Genes that Increase Lifespan

Comprehensive study finds 238 genes that affect aging in yeast cells.
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Surprising results in study of mitochondrial dysfunction in skin casts light on the free radical theory of aging

Scientists in the Campisi lab at the Buck Institute bred mice that produced excess free radicals that damaged the mitochondria in their skin
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An imbalance of cellular bioenergetics in pancreatic beta-cells is linked to type 2 diabetes

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes...
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Low-dose lithium prevents Parkinson’s symptoms in aged mice with a human mutation for the disease

Study provides further validation that lithium could be repurposed as a therapy for the incurable neurodegenerative disorder
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Senescent cells play an essential role in wound healing

Study highlights ability to avoid a potential side effect of healthspan extending drugs
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Could ibuprofen be an anti-aging medicine?

Study shows popular over-the counter drug extends lifespan in yeast, worms and flies
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Henri Jasper
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Buck Faculty Henri Jasper, PhD, Receives Prestigious BIG Award

Buck faculty Henri Jasper, PhD, gets prestigious “Breakthroughs in Gerontology” award from the Glenn Foundation and the American Federation for Aging Research
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Leading scientists identify research strategy for highly intertwined “pillars of aging”

Leading scientists identify research strategy for highly intertwined “pillars of aging” as next step in supporting the trans-NIH Geroscience Interest Group’s efforts to integrate aging into research on chronic diseases
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Memory loss associated with Alzheimer’s reversed for first time

In a novel, personalized and comprehensive program to reverse memory loss, nine of 10 participants displayed subjective or objective improvement in their memories
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Researchers propose “disruptive” new system to reclassify tumors

Largest cancer genomic study proposes “disruptive” new system to reclassify tumors
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Rachel Brem, PhD, Joins Buck Institute Faculty

Associate Professor studies naturally-occurring genetic variations that impact characteristics of aging
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Buck Institute Mourns Death of Catherine Munson, Long-Time Trustee and former Board Chair

Iconic Realtor was Community Activist and Philanthropist
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Five-Fold Lifespan Extension in C. Elegans by Combining Mutants

Research Highlights Possibility of Combination Therapy for Aging
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Aging Impacts Epigenome in Human Skeletal Muscle

Buck Institute research involves first genome-wide DNA methylation study in disease-free tissue
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The Buck Institute for Research on Aging and the University of Southern California Launch the Nation’s First PhD Program in the Biology of Aging

Program is a Landmark in the History of the Buck
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Major Alzheimer’s Risk Factor Linked to Red Wine Target

Buck Institute study provides insight for new therapeutics that target the interaction between ApoE4 and a Sirtuin protein
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Research in Aging Fruit Flies May Explain the Roots of Metabolic Dysfunction in Aging Humans

Findings provide a rationale for "Why We Just Can’t Eat What We Used To"
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Buck Institute Adds Two New Faculty

Their research focuses on very different realms of the nervous system
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Research in Fruit Flies Provides New Insight into Barrett’s Esophagus

A new study suggests a change in stem cell function causes cells in lower esophagus to transform into stomach-like cells
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Buck Faculty Receives Prestigious Tenovus Award

Buck faculty Gordon Lithgow, PhD, has received the prestigious 2013 Tenovus-Scotland Medal
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Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

Rapamycin is already FDA approved for other indications
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Buck Scientists Publish Genome-Scale Study Identifying Hundreds of Potential Drug Targets for Huntington’s Disease

Scientists searching for ways to develop treatments for Huntington’s disease (HD) just got a roadmap that could dramatically speed their discovery process
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Arthur and Drue Gensler Donate $5 Million to Buck Institute

Gift from Board Member and Architectural Visionary Will be Honored by the Naming of Administrative Building
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Advanced Courses for Scientists
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Buck Institute Announces its Founding Partnership with Delos Pharmaceuticals

New Company is Developing Therapeutics for Age-Associated Disease
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Buck Institute and UC Santa Cruz Collaborators Make Significant Contribution to Landmark Breast Cancer Study

TCGA study demonstrates existence of four main classes of breast cancer; Buck collaboration points to similarities between a type of breast and ovarian cancer
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Stem Cell Agency Awards Buck Faculty $1.5 Million to Make 3-D Model of the Retina

Efforts to understand and treat degenerative eye diseases utilizing stem cell technology just got a boost
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Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

FDA-approved drug improves cardiac and skeletal muscle function and extends lifespan
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Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction

Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process
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Buck Scientists Correct Huntington’s Disease Mutation in Induced Pluripotent Stem Cells

Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington’s disease (HD) using a human induced pluripotent stem cell
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Glenn Foundation Awards Buck Institute $1 Million to Establish Training Fellowships in the Biology of Aging

The monies will bring new postdoctoral fellows to the Buck Institute, funding two years of research for each of 10 scientists
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Management Consultant, Community Leader James Edgar Elected to Chair Buck Institute Board of Trustees

James M. Edgar, a life-long management consultant and community leader has been elected Chair of the Board of Trustees
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Buck Institute Adds Two New Faculty

Stem cell technologies will be utilized to study vision disorders and skeletal muscle physiology
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Scientists Turn Back the Clock on Adult Stem Cells Aging

Reversing the aging process could lead to medical treatments for many chronic conditions
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Researchers Flip the Switch Between Aging and Development in C. elegans

Buck Institute scientists note first observation of genome-wide shift kicked off at level of translation that extends lifespan
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Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease

Buck Institute research in mice moves into preclinical stage; Buck working toward human trial
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John W. “Jack” Rowe Donates $1 Million to Buck Institute

Gift from healthcare visionary who helped establish the Buck is announced at the kick-off event for the new Buck Advisory Council.
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A New Role for Endocannabinoid Signaling in Dietary Restriction and Lifespan Extension

Study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability
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Common Laboratory Dye is a Wonder Drug — for Worms

Study in Nature shows Basic Yellow 1 profoundly extends lifespan in healthy nematodes, and slows Alzheimer's disease-like pathology in worms
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Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD

Physician-Scientist was a Pioneer in Medical Genetics, Down Syndrome and Aging Research
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Novel Method Results in Promising Drugs for Huntington’s Disease Therapeutics

Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are underway in mice
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Buck Institute Awarded $6 Million to Lead Effort to Get Stem Cell Treatment for Parkinson’s Disease Ready for Clinical Trials

The Buck Institute for Age Research has been awarded $6 million from the California Institute for Regenerative Medicine to fund a three-year project aimed at getting a stem cell derived treatment for Parkinson's disease
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A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response

Buck Institute study says it’s about translation, not just transcription
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Scientists Successfully Use Human Induced Pluripotent Stem Cells to Treat Parkinson’s Disease in Rodents

Technologies developed at Buck Institute can speed the manufacturing of authentic neurons from stem cells for future clinical applications
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BIOMARIN - Providing innovative therapeutics to patients with serious unmet medical needs.
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Buck Institute Partners with BioMarin to Expand Early Research on Novel Treatment for Familial Alzheimer’s Disease

The Buck Institute for Age Research announced that it has entered into a research collaboration with BioMarin Pharmaceutical Inc...
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Leap Forward in Efforts to Develop Treatments for Huntington’s Disease

Buck Institute scientists identify new targets for drug development, some of which already respond to cancer drugs
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Brian K. Kennedy, PhD, Appointed as New CEO of Buck Institute for Age Research

Kennedy, who has earned an international reputation for his work in the basic biology of aging, comes to the Buck Institute from the University of Washington in Seattle where he most recently served in the Department of Biochemistry
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Fruit Flies Provide New Clues on How Organisms Make Dietary Choices

Research at Buck Institute for Age Research opens the door for future treatments for metabolic and eating disorders
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Buck Institute Study Suggests New Strategy for Treatment of Stroke

Research in rodents highlights need for human clinical trials of antidepressants and other drugs shown to increase growth of new neurons
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Here’s what’s happening

Upcoming events that feature Buck science

Ongoing

Formal Research Seminars

Click “read more” for full schedule

Paint the Town Red

Novato's 59th birthday party!

Marc Freedman on How to Live Forever

Buck hosts the Commonwealth Club

If you missed last Monday's #30yearsofaging meeting or wanted to relive the discussions, check out today's blog post: https://t.co/NXZGRR4RMU You will also get to hear what some of the attendees thought of the meeting! #livebetterlonger”

Did you know? The Buck’s regenerative medicine program involves replacing damaged cells, enhancing adult stem cells to rejuvenate tissues and genetically altering deadly mutations. #livebetterlonger #knowthebuck Learn more fun science facts at https://t.co/JTrJ0L5F9F

Did you know? About 65% of older adults suffer from a chronic disease and 43% have three or more. At the Buck, our research is all about reducing these numbers. #livebetterlonger #30yearsofaging Learn more about aging at https://t.co/JhDVBOMQ8q

At Friday's FRS, Dr. Claudio Hetz at @uchile discussed his proteostasis work! Maintaining proteostasis (protein + homeostasis) is important for healthy brain aging because it prevents abnormal protein aggregation. Check out our upcoming FRSs: https://t.co/BXRsNfvSmU

Raising NAD+ levels has been linked to lifespan and #healthspan extension in model organisms. In our latest #livebetterlonger blog post, @DominicanCANews master's student Geoff Meyerhof discusses new research aimed at boosting NAD+ production in vivo. https://t.co/aTXrA5M8lO