Huntington’s disease: Modulating rapamycin target protein FKBP51 pathway promotes autophagy, lowering Huntingtin protein
Experiments with small molecule has implications for research on aging.
A new predictive model helps identify those at risk for severe COVID-19
Buck scientists analyze data from 3 million people using a smartphone app in the United Kingdom
A compound that slows bone loss, and a resource for developing treatments to slow aging
Longitudinal and functional study of 700 aging mice provides a treasure trove of data for those studying aging and age-related diseases
Tissue stiffness likely drives immune responses in many chronic diseases
Buck research points to the possibility of new immunotherapeutics and highlights critically needed changes in experimental techniques
Buck Institute Names Malene Hansen as Chief Scientific Officer
Dr. Malene Hansen is joining the Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission”
Chronic inflammation causes a reduction in NAD+
Buck research links hallmarks of aging: senescent cells activate CD38 which degrades NAD+, a key metabolite implicated in age-related decline
A metabolite produced by the body increases lifespan and dramatically compresses late-life morbidity in mice
Alpha-ketaglutarate improves several measures of healthspan in double-blind study
Global Consortium for Reproductive Longevity & Equality Announces First Grant Recipients
22 Researchers Selected to Receive $7...
USC Leonard Davis School of Gerontology and The Buck Institute for Research on Aging Win $4.6 Million NIA Grant
Prestigious award establishes the USC-Buck Nathan Shock Center of Excellence in the Basic Biology of Aging.
Researchers outline strategy for testing ketone bodies against COVID-19, other respiratory infections
Review in Med highlights the role of geroscience in the fight against this and future pandemics.
New tools will enhance the specificity of imaging in the mouse brain
Researchers image neural circuits by targeting the cell body using ribosome tethering
Eat less and live a long healthy life? Study shows “not in all cases”
Results from research involving 160 genetically distinct strains of fruit flies give insight into what will likely happen in humans using dietary restriction to add extra years (and extra health) to life.
Buck researchers discover how cellular senescence leads to neurodegeneration
Findings available to scientists studying both dementia and brain cancer.
Experts call on the World Health Organization, governments and medical communities to develop common classifications and systems to diagnose and treat age-related diseases.
An international team of researchers have put forward a position statement, published in Science, which lays out a new healthcare framework to help aging populations stay healthier for longer...
The Buck gets $3.8 M Transformative Research Award from the NIH
A mouse that can regrow axons after brain injury is the focus of a new method to pinpoint genetic differences between species
The Bia-Echo Foundation announces the Global Consortium for Female Reproductive Longevity and Equality in partnership with the Buck Institute
The Consortium will award $7...
Cellular senescence is associated with age-related blood clots
Publishing in the September 24 edition of Cell Reports, researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots...
Uric acid pathologies shorten lifespan in flies, highlighting the need for screening in humans
Backed by human genetics, research in flies provides potential drug targets for gout, metabolic syndrome, diabetes and kidney stones
The Buck announces first faculty appointments for the Center for Female Reproductive Longevity and Equality
Lei Lei, PhD, Shiying Jin, PhD, Francesca Duncan, PhD, and Jennifer Garrison, PhD are the first faculty members to join the Buck Institute’s Center for Female Reproductive Longevity and Equality.
Buck professor Gordon Lithgow receives prestigious award from the American Aging Association
Denham Harman Award recognizes lifetime achievement in research on aging
Buck Professor Emeritus David Nicholls elected to the Royal Society
Buck faculty help found Academy for Health and Lifespan Research
A group of the world’s leading scientists form nonprofit aimed at accelerating breakthroughs to extend human healthspan.
Does dietary restriction protect against age-related leaky gut?
Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract...
A new method to pinpoint genetic differences between species
Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms...
Tara Tracy joins faculty at Buck Institute
Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s
Three leaders in longevity biotechnology form a research collaboration
The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics
World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging
A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's...
First patient treated with drug based on Buck research
Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial
Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials
Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project.
Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty
Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice.
A Potential New Therapeutic Approach for Parkinson’s Disease
A potential new therapeutic approach for Parkinson’s disease.
Inhibiting TOR boosts regenerative potential of adult tissues
Rapamycin prevents age-related loss of stem cells
Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research
The funding will Dr. Lisa Ellerby's work in Huntington's disease
Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant
Chuankai Zhou is awarded prestigious Early Independence Award from NIH
Some women with history of preeclampsia have significantly lower risk for breast cancer
Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant
Large data set brings precision to breast cancer diagnosis and care
Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence
Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project
The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity
Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease
Buck Institute research leads to clinical trial for cystinuria at UCSF
Senescence promotes chemotherapy side effects and cancer relapse
Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.
Improving the longevity of functionally integrated stem cells in regenerative vision therapy
Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells
Research in worms provides a model to study how the microbiome influences disease in humans
The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity
Buck Institute study provides neuronal mechanism for the benefits of fasting
The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function
BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH
ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO
Buck Institute Appoints Edward Lanphier President and CEO
The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer
Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease
Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J...
A new look at vitamin D challenges the current view of its benefits
Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases
Research in worms provides path to study diabetic complications
Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems
Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases
As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty...
Future therapeutics: drugs that stop free radicals at their source
Research at the Buck Institute yields molecules that prevent free radical production by cells
Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype
Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology
Intracellular calcium integrates complex signaling to control stem cell activity
Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation
Dietary restriction gives fruit flies a rhythm for a long life
Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development
$1.25 million bequest funds first named professorship at Buck Institute
Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1...
Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease
Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field.
Buck Faculty Jennifer Garrison Announced as an Allen Institute for Brain Science 2015 Next Generation Leader
Assistant professor Jennifer Garrison, PhD, has been selected as one of this year’s six Next Generation Leaders at the Allen Institute for Brain Science...
Mapping the Genes that Increase Lifespan
Comprehensive study finds 238 genes that affect aging in yeast cells.
Surprising results in study of mitochondrial dysfunction in skin casts light on the free radical theory of aging
Scientists in the Campisi lab at the Buck Institute bred mice that produced excess free radicals that damaged the mitochondria in their skin
An imbalance of cellular bioenergetics in pancreatic beta-cells is linked to type 2 diabetes
Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes...
Low-dose lithium prevents Parkinson’s symptoms in aged mice with a human mutation for the disease
Study provides further validation that lithium could be repurposed as a therapy for the incurable neurodegenerative disorder
Senescent cells play an essential role in wound healing
Study highlights ability to avoid a potential side effect of healthspan extending drugs
Could ibuprofen be an anti-aging medicine?
Study shows popular over-the counter drug extends lifespan in yeast, worms and flies
Buck Faculty Henri Jasper, PhD, Receives Prestigious BIG Award
Buck faculty Henri Jasper, PhD, gets prestigious “Breakthroughs in Gerontology” award from the Glenn Foundation and the American Federation for Aging Research
Leading scientists identify research strategy for highly intertwined “pillars of aging”
Leading scientists identify research strategy for highly intertwined “pillars of aging” as next step in supporting the trans-NIH Geroscience Interest Group’s efforts to integrate aging into research on chronic diseases
Memory loss associated with Alzheimer’s reversed for first time
In a novel, personalized and comprehensive program to reverse memory loss, nine of 10 participants displayed subjective or objective improvement in their memories
Researchers propose “disruptive” new system to reclassify tumors
Largest cancer genomic study proposes “disruptive” new system to reclassify tumors
Rachel Brem, PhD, Joins Buck Institute Faculty
Associate Professor studies naturally-occurring genetic variations that impact characteristics of aging
Buck Institute Mourns Death of Catherine Munson, Long-Time Trustee and former Board Chair
Iconic Realtor was Community Activist and Philanthropist
Five-Fold Lifespan Extension in C. Elegans by Combining Mutants
Research Highlights Possibility of Combination Therapy for Aging
Aging Impacts Epigenome in Human Skeletal Muscle
Buck Institute research involves first genome-wide DNA methylation study in disease-free tissue
The Buck Institute for Research on Aging and the University of Southern California Launch the Nation’s First PhD Program in the Biology of Aging
Program is a Landmark in the History of the Buck
Major Alzheimer’s Risk Factor Linked to Red Wine Target
Buck Institute study provides insight for new therapeutics that target the interaction between ApoE4 and a Sirtuin protein
Research in Aging Fruit Flies May Explain the Roots of Metabolic Dysfunction in Aging Humans
Findings provide a rationale for "Why We Just Can’t Eat What We Used To"
Buck Institute Adds Two New Faculty
Their research focuses on very different realms of the nervous system
Research in Fruit Flies Provides New Insight into Barrett’s Esophagus
A new study suggests a change in stem cell function causes cells in lower esophagus to transform into stomach-like cells
Buck Faculty Receives Prestigious Tenovus Award
Buck faculty Gordon Lithgow, PhD, has received the prestigious 2013 Tenovus-Scotland Medal
Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice
Rapamycin is already FDA approved for other indications
Buck Scientists Publish Genome-Scale Study Identifying Hundreds of Potential Drug Targets for Huntington’s Disease
Scientists searching for ways to develop treatments for Huntington’s disease (HD) just got a roadmap that could dramatically speed their discovery process
Arthur and Drue Gensler Donate $5 Million to Buck Institute
Gift from Board Member and Architectural Visionary Will be Honored by the Naming of Administrative Building
Buck Institute Announces its Founding Partnership with Delos Pharmaceuticals
New Company is Developing Therapeutics for Age-Associated Disease
Buck Institute and UC Santa Cruz Collaborators Make Significant Contribution to Landmark Breast Cancer Study
TCGA study demonstrates existence of four main classes of breast cancer; Buck collaboration points to similarities between a type of breast and ovarian cancer
Stem Cell Agency Awards Buck Faculty $1.5 Million to Make 3-D Model of the Retina
Efforts to understand and treat degenerative eye diseases utilizing stem cell technology just got a boost
Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction
FDA-approved drug improves cardiac and skeletal muscle function and extends lifespan
Physical Activity Needed In Order To Reap Benefits Of Dietary Restriction
Research in flies points to enhanced fatty acid metabolism in muscle as a key driver of the lifespan extending process
Buck Scientists Correct Huntington’s Disease Mutation in Induced Pluripotent Stem Cells
Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington’s disease (HD) using a human induced pluripotent stem cell
Glenn Foundation Awards Buck Institute $1 Million to Establish Training Fellowships in the Biology of Aging
The monies will bring new postdoctoral fellows to the Buck Institute, funding two years of research for each of 10 scientists
Management Consultant, Community Leader James Edgar Elected to Chair Buck Institute Board of Trustees
James M. Edgar, a life-long management consultant and community leader has been elected Chair of the Board of Trustees
Buck Institute Adds Two New Faculty
Stem cell technologies will be utilized to study vision disorders and skeletal muscle physiology
Scientists Turn Back the Clock on Adult Stem Cells Aging
Reversing the aging process could lead to medical treatments for many chronic conditions
Researchers Flip the Switch Between Aging and Development in C. elegans
Buck Institute scientists note first observation of genome-wide shift kicked off at level of translation that extends lifespan
Lithium Profoundly Prevents Brain Damage Associated with Parkinson’s Disease
Buck Institute research in mice moves into preclinical stage; Buck working toward human trial
John W. “Jack” Rowe Donates $1 Million to Buck Institute
Gift from healthcare visionary who helped establish the Buck is announced at the kick-off event for the new Buck Advisory Council.
A New Role for Endocannabinoid Signaling in Dietary Restriction and Lifespan Extension
Study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability
Common Laboratory Dye is a Wonder Drug — for Worms
Study in Nature shows Basic Yellow 1 profoundly extends lifespan in healthy nematodes, and slows Alzheimer's disease-like pathology in worms
Buck Institute Mourns Death of Former Board Chair Charles J. Epstein, MD
Physician-Scientist was a Pioneer in Medical Genetics, Down Syndrome and Aging Research
Novel Method Results in Promising Drugs for Huntington’s Disease Therapeutics
Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are underway in mice
Buck Institute Awarded $6 Million to Lead Effort to Get Stem Cell Treatment for Parkinson’s Disease Ready for Clinical Trials
The Buck Institute for Age Research has been awarded $6 million from the California Institute for Regenerative Medicine to fund a three-year project aimed at getting a stem cell derived treatment for Parkinson's disease
A New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response
Buck Institute study says it’s about translation, not just transcription
Scientists Successfully Use Human Induced Pluripotent Stem Cells to Treat Parkinson’s Disease in Rodents
Technologies developed at Buck Institute can speed the manufacturing of authentic neurons from stem cells for future clinical applications
Buck Institute Partners with BioMarin to Expand Early Research on Novel Treatment for Familial Alzheimer’s Disease
The Buck Institute for Age Research announced that it has entered into a research collaboration with BioMarin Pharmaceutical Inc...
Leap Forward in Efforts to Develop Treatments for Huntington’s Disease
Buck Institute scientists identify new targets for drug development, some of which already respond to cancer drugs
Brian K. Kennedy, PhD, Appointed as New CEO of Buck Institute for Age Research
Kennedy, who has earned an international reputation for his work in the basic biology of aging, comes to the Buck Institute from the University of Washington in Seattle where he most recently served in the Department of Biochemistry
Fruit Flies Provide New Clues on How Organisms Make Dietary Choices
Research at Buck Institute for Age Research opens the door for future treatments for metabolic and eating disorders
Buck Institute Study Suggests New Strategy for Treatment of Stroke
Research in rodents highlights need for human clinical trials of antidepressants and other drugs shown to increase growth of new neurons
Buck Institute Awarded $1.5 Million for Stem Cell Training
Three-year grant from California Institute for Regenerative Medicine will bring six new postdoctoral fellows to the Buck
“Anti-Atkins” Low Protein Diet Extends Lifespan in Flies
Diet boosts mitochondrial function, has implications for humans
DNA Damaged Cells Communicate with Neighbors to Let them Know They’re in Trouble
Buck Institute research has implications in aging and cancer
NIH supports Buck Institute’s Innovative Alzheimer’s Research with $1.6 Million “EUREKA” Grant
The highly competitive grant was awarded to Buck faculty member and founding CEO Dale Bredesen, MD...
Buck Scientists Identify a Key Protein That May Explain the Anti-Aging and Anti-Cancer Benefits of Dietary Restriction
The finding provides a new understanding of how dietary restriction contributes to longevity and cancer prevention and gives scientists new targets for developing and testing drugs that could extend the healthy years of life.
Sean Mooney, PhD, Joins Buck Faculty
Appointment highlights emphasis on bioinformatics and collaborative research
Escape Cancer, But Age Sooner?
Buck Institute scientists unravel the dark side of the tumor suppressing process
Buck Institute Study Shows Mixed Results for Life-Extending Properties of Antioxidants
Findings underscore need for consumer caution when taking supplements
Buck Institute Receives $1.5 Million from Keck Foundation to Study Aging As Causal Factor for Disease
The research from Julie Andersen, PhD and Brad Gibson, PhD will bring together the disciplines of neuroscience, mitochondrial proteomics, functional bioenergetics and the biology of aging to test an idea that is likely to influence the way the biomedical community views research on age-related disease.
Martin Brand, PhD, Joins Buck Faculty
Appointment establishes Institute’s research focus on diabetes
Growth Factor Promotes New Neuron Growth in Mouse Model of Parkinson’s Disease
Mice induced to develop Parkinson’s disease (PD) show an increase in the growth of new neurons after they are treated with a well known growth factor...
Buck Institute Receives $20.5 Million for New Stem Cell Building
The CIRM award would provide seed money for the institute’s second research facility...
Victoria Lunyak, PhD, Joins Buck Faculty
Appointment establishes program in epigenetics and aging
Paradoxical Alzheimer’s Finding May Shed New Light on Memory Loss
The study provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD.
Buck Institute Announces Senior Management Change
Dale Bredesen, MD, will discontinue his duties as CEO to spend more time on a private start-up health promotion and disease prevention company that he recently co-founded...
Glutathione Depletion Leads to Symptoms of Parkinson’s Disease in Mice
Buck Institute study provides new model for the study of the neurodegenerative disease while highlighting the role of aging in disease development
Drug Commonly Used to Treat Bi-Polar Disorder Dramatically Increases Lifespan in Nematode Worms
Buck Institute Awarded $25 Million to Establish New Scientific Discipline of Geroscience
Combined Exposure to Environmental Toxics Accelerates Age-Related Development of Parkinson’s Disease in Mice
Buck Institute study highlights the role of environmental factors in the most common form of the neurodegenerative disease
Buck Institute Awarded $4.1 Million for Shared Research and Laboratory and Training Facility for Human Embryonic Stem Cell Research
Exercise Reverses Aging in Human Skeletal Muscle
Buck Institute faculty lead study showing “genetic fingerprints” becoming younger in healthy seniors who did resistance training
Landmark Study Identifies a Large Number of New Proteins Implicated in Huntington’s Disease
Buck Institute faculty leads large scale screening of protein interactions to identify drug targets for possible treatment of incurable neurodegenerative disease
Unprecedented Screening of Up to 120,000 Chemical Compounds for Lifespan Extension to Begin
Grant establishes “Hillblom Chemical Biology of Aging Network” at Buck Institute for Age Research
Overexpression of Human Protein Reduces Severity of Alzheimer’s Disease in Mice
Ultimate goal of research is to identify drugs which boost the body’s attempt to heal itself
Buck Institute Study Finds Inflammation is a Culprit in Nerve Death in Mouse Model of Parkinson’s Disease
Discovery offers new model to explore anti-inflammatory treatments for progressive, incurable neurodegenerative disease
Buck Institute Study Shows Newborn Neurons May Promote Stroke Recovery in Humans
Is it Time to Reexamine Iron Content in Infant Formula?
Neonatal mice fed the equivalent amount of iron used in human infant formula develop Parkinson’s-like neurodegeneration as they age
Proteins Linked to Cancer Prevention in Humans Affect Aging in Worms
Discovery opens a new avenue of inquiry into aging as a risk factor for cancer
Buck Study Provides a Startling New Look at Alzheimer’s
Mouse brains look like Alzheimer’s, but mouse memories do just fine
Growth Factor Promotes New Neuron Growth and Increased Survival in Mice with Huntington’s Disease
Buck Institute study shows potential for new avenue of treatment for incurable, hereditary brain disorder