A mission-driven community of investigators

The Buck is a collective of the world’s top scientists in the field of research on aging who are sharing their methods and expertise to find ways to help everyone lead fuller, healthier lives by ending age-related disease.

A rather disruptive bunch

The Buck Institute’s 20 principal investigators share the audacious notion that biological aging is malleable. Some of our scientists have been here since the Institute opened its doors; others are newcomers. They all bring their specific areas of expertise to collaborations intended to push the boundaries of scientific inquiry.

Julie Andersen, PhD

Professor
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Chris Benz, MD

Professor
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Martin Brand, PhD

Professor
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Rachel Brem, PhD

Associate Professor
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Judith Campisi, PhD

Professor
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Lisa Ellerby, PhD

Professor
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Jennifer Garrison, PhD

Assistant Professor
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Pejmun Haghighi, PhD

Professor
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Henri Jasper Buck Institute

Heinrich Jasper, PhD

Professor
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Pankaj Kapahi, PhD

Professor
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Brian K. Kennedy, PhD

Professor
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Gordon Lithgow, PhD

Professor, Chief Academic Officer
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Simon Melov, PhD

Professor
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John Newman, MD, PhD

Assistant Professor
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Arvind Ramanathan, PhD

Assistant Professor
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Birgit Schilling, PhD

Assistant Professor
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Tara Tracy, PhD

Assistant Professor
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Eric Verdin, MD

President and Chief Executive Officer, Professor
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Xianmin Zeng, PhD

Professor
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Kai Zhou, PhD

Buck Fellow
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Kai Zhou, PhD

Buck Fellow
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Akos Gerenscer, PhD

Assistant Director of the Morphology and Imaging Core and Research Associate Professor

Dr. Akos Gerencser has a dual background in medicine and biomedical engineering. He is experienced in mitochondria-and cell physiology-related, fluorescence microscopy-based technique development. He has designed the oxygen consumption rate calibration algorithm of the Seahorse Extracellular Flux Analyzer. He has developed a set of image processing technologies specifically designed for quantification of mitochondrial calcium, shape changes and motion in fluorescence microscopy recordings. He has studied the role of mitochondrial dynamics in neuronal apoptosis and neurodegeneration, as well as bioenergetics and mitochondrial dysfunction in neurodegenerative disease models and mechanisms of insulin secretion in pancreatic beta cell models. His current interest is the development of mitochondrial membrane potential assays that report potentials in absolute millivolts independently of the plasma membrane potential and geometric factors.

As Assistant Director of the Morphology and Imaging Core, Akos Gerencser, PhD, is available to discuss high-level imaging collaborative ideas, particularly live cell imaging, deep tissue imaging, and multispectral imaging.

AGerenscer@buckinstitute.org

Birgit Schilling, PhD

Director of the Mass Spectrometry Core and Research Associate Professor

Dr. Birgit Schilling received her Diploma and PhD in Chemistry in Germany (University of Hamburg and Clausthal), and did a postdoctoral fellowship with Professors Al Burlingame and Brad Gibson at UCSF in San Francisco, CA. Dr. Schilling has joined the Buck Institute and Proteomics lab in 2000, and has extensive experience in mass spectrometric technologies for over 25 years. She has specialized in quantitative proteomics in the context of aging, and also MS method and workflow developments, such as for posttranslational modifications, protein secretomes, exosomes, biomarkers, protein turnover and proteostasis. She is a leader in the field of applying novel MS scan types, such as data-independent acquisitions (DIA), parallel reaction monitoring (PRM) and corresponding data processing. Dr. Schilling oversees all proteomics projects and coordinates all collaborations.

BSchilling@buckinstitute.org

Brian Ackrell, PhD

Michelle Arkin, PhD

Rochelle Buffenstein, PhD

Julio Cardenas, PhD

Felipe Court, PhD

Christian Gonzalez, PhD

Claudio Hetz, PhD

Nevan J. Krogan, PhD

Deepak Lamba, PhD

David Madden, PhD

Shona Mookerjee, PhD

Marshall Stoller, MD

Alex Zhavoronkov, PhD

Dale Bredesen, MD

David Greenberg, MD, PhD

David Nicholls, PhD

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