NEWS

From the bench to the boardroom

News from the Buck and beyond

Press Release . Jan 15, 2019

MANF identified as a rejuvenating factor in parabiosis

Buck researchers also harness an innate repair mechanism to protect against liver damage in aging mice and extend lifespan in flies...

Research . Jan 08, 2019

Exploiting a gene that protects against Alzheimer’s

Anyone who gets tested for their genetic risk for Alzheimer’s disease likely knows about ApoE4...

news . Dec 05, 2018

Buck celebrates 30 years of research on aging with major symposium

Leading scientists from across the nation gathered at the Buck on December 3rd to celebrate research on aging.

news . Nov 15, 2018

A small foundation has a huge impact on Buck educational programs

Established in 2015, the Navigage Foundation is just getting its feet wet when it comes to supporting efforts to enhance and improve the lives of older adults...

Press Release . Nov 06, 2018

Does dietary restriction protect against age-related leaky gut?

Buck Institute research shows that diet impacts the fitness of cells lining the intestinal tract...

What I want people to know about the Buck is the incredible commitment and excitement that permeates the walls of this institution. We are pushing the frontiers in an area that is going to impact all of humanity. I cannot tell you exactly when this will happen, but I can tell you big discoveries will come out of the Buck.

Eric Verdin, MD, Buck Institute President and CEO

news . Oct 16, 2018

Buck researchers get $3.4 million to look at a fruit-derived metabolite as a possible treatment for Alzheimer’s

Could a gut metabolite produced from dietary ellagic acid, which is abundant in strawberries, blackberries, cranberries, pomegranates and walnuts, help prevent or reverse Alzheimer’s disease?

news . Oct 08, 2018

A new method to pinpoint genetic differences between species

Publishing in Nature Genetics, research from the Buck Institute lays the groundwork for the mapping of genes to traits throughout the plant and animal kingdoms...

news . Sep 04, 2018

Advanced Glycation End Products As Drivers of Age-Related Disease

Pankaj Kapahi makes his case to the research community and the public

news . Aug 28, 2018

Tara Tracy joins faculty at Buck Institute

Neuroscientist studies synaptic dysfunction and cognitive decline in Alzheimer’s

news . Aug 14, 2018

Three leaders in longevity biotechnology form a research collaboration

The Buck Institute, Juvenescence, and Insilico Medicine announce a research collaboration utilizing AI to discover and develop novel anti-aging therapeutics targeting a new molecular pathway and found Napa Therapeutics

news . Jul 25, 2018

World’s first Center for Female Reproductive Longevity and Equality established at the Buck Institute for Research on Aging

A $6 million gift provides seed money to address a long-standing inequality: men can reproduce throughout their lifespan; but women's fertility begins to decline in their early 30's...

news . Jul 23, 2018

Buck faculty member Pankaj Kapahi spearheads mentoring efforts for disadvantaged children in India

Kapahi grew up in India with every advantage...

news . Jul 09, 2018

First patient treated with drug based on Buck research

Unity Biotechnology, which incubated at the Buck Institute, has treated the first patient in a Phase I clinical trial

news . May 30, 2018

Judy Campisi elected to the National Academy of Sciences for her pioneering work on cellular senescence

How does great science happen, and how does a great scientist get her start? The answers might surprise you.

news . Apr 05, 2018

Largest “pan-cancer” genomics study spurs future efforts to enroll patients in specialized “basket” clinical trials

Buck professor Chris Benz is senior co-author of several papers publishing in Cell based on the Cancer Genome Atlas project.

news . Mar 13, 2018

Geriatrician-scientist John Newman, MD, PhD, joins the Buck faculty

Geriatrician and researcher in the field of aging poised to bridge gap between lab and clinical practice.

news . Jan 23, 2018

A Potential New Therapeutic Approach for Parkinson’s Disease

A potential new therapeutic approach for Parkinson’s disease.

news . Dec 07, 2017

Inhibiting TOR boosts regenerative potential of adult tissues

Rapamycin prevents age-related loss of stem cells

news . Nov 20, 2017

Taube Philanthropies Grants $750,000 to Buck Institute for Huntington’s Disease Research

The funding will Dr...

news . Oct 05, 2017

Exceptional Early Career Scientist Joins the Buck with a $2.4M Federal Grant

Chuankai Zhou is awarded prestigious Early Independence Award from NIH

news . Sep 05, 2017

Ketogenic diet improves healthspan and memory in aging mice

Study on the effects of ketone bodies opens up new area of inquiry in research on aging.

news . Aug 29, 2017

Some women with history of preeclampsia have significantly lower risk for breast cancer

Researchers utilize samples from California Teachers Study to confirm protection comes via a common genetic variant

news . May 04, 2017

Large data set brings precision to breast cancer diagnosis and care

Buck Institute faculty Chris Benz, MD, is a co-author on a study finding genetic variations common in black women could improve outcomes, reduce recurrence

news . Feb 21, 2017

Longevity-promoting superstar gets revealed in Caenorhabditis reproducibility project

The Caenorhabditis Intervention Testing Program shows that genetic background and scientific methods impact efforts to identify compounds that affect longevity

news . Feb 06, 2017

Alpha-lipoic acid prevents kidney stones in mouse model of rare genetic disease

Buck Institute research leads to clinical trial for cystinuria at UCSF

news . Jan 17, 2017

Senescence promotes chemotherapy side effects and cancer relapse

Eliminating pro-inflammatory cells after treatment relieves symptoms in mice.

news . Jan 12, 2017

Improving the longevity of functionally integrated stem cells in regenerative vision therapy

Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells

news . Jan 04, 2017

Real Estate Entrepreneur Bill Poland Chairs Buck Institute Board of Trustees

Prominent San Francisco commercial real estate developer Bill R...

news . Dec 13, 2016

Research in worms provides a model to study how the microbiome influences disease in humans

The interaction between bacteria and worms can be used to understand host-microbiome signals in humans that contribute to diseases such as type 2 diabetes and obesity

news . Dec 01, 2016

Buck Institute study provides neuronal mechanism for the benefits of fasting

The first molecular details are uncovered, in fruit flies, about how nutrient scarcity influences synapse function

news . Nov 18, 2016

BUCK ANNOUNCES NEW CEO AND $10 MILLION IN GIFTS TO FUEL GROWTH

ERIC VERDIN NAMED PERMANENT PRESIDENT AND CEO

news . Oct 28, 2016

Buck Institute Appoints Edward Lanphier President and CEO

The Buck Institute for Research on Aging (Buck Institute) today announced the appointment of Edward Lanphier as president and chief executive officer

news . Oct 18, 2016

Buck faculty Julie Andersen, PhD, receives grant from Michael J. Fox Foundation to study brain aging as a factor in Parkinson’s disease

Buck professor Julie Andersen, PhD, has received $200,000 from The Michael J...

news . Oct 18, 2016

A new look at vitamin D challenges the current view of its benefits

Research in C elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases

news . Oct 13, 2016

Research in worms provides path to study diabetic complications

Scientists find sensor for toxic molecules linked to excess blood sugar and identify natural compounds that may provide new therapies for serious health problems

news . Oct 13, 2016

Buck Institute’s Jennifer Garrison, Phd Receives $100,000 AFAR Grant for Junior Faculty to Advance Research in the Biology of Aging and Age-Related Diseases

As it commemorates its 35th anniversary, the American Federation for Aging Research (AFAR) is proud to award Jennifer Garrison, PhD, Assistant Professor, Buck Institute for Research on Aging, with an AFAR Grant for Junior Faculty...

news . Sep 15, 2016

Future therapeutics: drugs that stop free radicals at their source

Research at the Buck Institute yields molecules that prevent free radical production by cells

news . Aug 24, 2016

Buck faculty Jennifer Garrison, PhD, receives prestigious $2.5 million award from NIH

Five-year MIRA grant supports lab-based research on neuropeptide signaling

news . Jul 28, 2016

Buck Institute study sheds light on gender differences in diabetes and aging

All’s not fair in love and glucose intolerance

news . Jul 06, 2016

Improving on a broccoli-related compound yields a possible treatment for macular degeneration

Buck Institute study also shows that palmitoleic acid protects the retina from environmental damage in mouse models of disease.

news . Jul 05, 2016

Metformin as a potential treatment for a rare pediatric disorder

Study in human skin cells and mice shows widely-used diabetes drug reduces toxic acid levels in Maple Syrup Urine Disease

news . Jun 15, 2016

Pre and post testing show reversal of memory loss from Alzheimer’s disease in ten patients

Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders

news . Jun 01, 2016

Buck researchers identify new “druggable” target for sporadic Parkinson’s disease

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson’s disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally...

news . May 26, 2016

Can we extend healthspan by altering the perception of food?

Tricking C elegans into a state of caloric restriction extends lifespan by 50% and suggests new targets for human pharmacology

news . May 17, 2016

Buck research may provide missing link in search for Parkinson’s disease therapeutics

Largest collection of induced pluripotent stem cell lines and related genomic assays from Parkinson’s patients provide a disease model which will be available to researchers world-wide

news . Mar 23, 2016

The Glenn Center for Biology of Aging Research Established at the Buck Institute

It is increasingly clear that inter-connected mechanisms drive age-related disease...

news . Feb 10, 2016

A new method furthers understanding of evolutionary genetics

Publishing in Nature Genetics, discovery helps unravel the mystery of ancient traits

news . Feb 10, 2016

Inhibiting age-related inflammation maintains healthy gut microbiota and extends lifespan

Blocking a well-known inflammatory pathway in the fly prevents abnormal changes in gut tissue, benefits gut bacteria and delays functional decline associated with age

news . Jan 22, 2016

The connection between excess iron and Parkinson’s disease

Excess iron impairs cellular recycling resulting in toxic oxidative stress

news . Jan 13, 2016

A surprising new role for ApoE offers explanation for its diverse range of effects, particularly in Alzheimer’s

Buck Institute/UCLA study finds that apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes...

news . Dec 10, 2015

Signaling from dysfunctional mitochondria induces cellular senescence with a distinct secretory phenotype

Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology

news . Nov 30, 2015

Intracellular calcium integrates complex signaling to control stem cell activity

Seminal discovery, publishing in Nature, reveals new mode of stem cell regulation

news . Nov 18, 2015

Dietary restriction gives fruit flies a rhythm for a long life

Research on circadian clocks identifies critical role for peripheral clock genes in fat metabolism and aging and presents new targets for drug development

news . Oct 22, 2015

$1.25 million bequest funds first named professorship at Buck Institute

Buck Institute breast cancer researcher Christopher Benz, MD, received the Institute’s first named professorship following a $1...

news . Oct 16, 2015

Rapamycin prevents Parkinson’s in mouse model of incurable neurodegenerative disease

Buck Institute study reveals much broader role for Parkin in cellular dynamics, challenging current dogma in the field.

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blog . Jan 08, 2019

Running trails or genetic pathways: The future of exercise

What if you could receive the benefits of exercise moving only the muscles necessary to take a pill?

blog . Dec 18, 2018

Keep Calm and Research On: How to separate hype from fact in biomedical research

How can you separate fact from hyperbole so that you can be informed?

blog . Dec 12, 2018

30 years and ongoing: Recap of the 30 years of aging research symposium

Last Monday, roughly 350 people gathered at the Buck to attend the “Live Better Longer: A Celebration of 30 Years of Research on Aging” symposium.

blog . Dec 06, 2018

A perennial molecule that treats pellagra and pauses aging

Recent paper shows a new approach to enhance the body's production of NAD+

blog . Nov 27, 2018

Giving Tuesday: Why give to the Buck

Why give to the Buck? Hear from some of our amazing donors.

blog . Nov 15, 2018

Longevity: Is it all in the family?

For many of us, our parents have given us a lot...

blog . Nov 13, 2018

Welcome to the inaugural edition of the Live Better Longer blog!

The Buck Institute’s official blog on aging.

Dec 8, 2018

Fountains of youth: Biotech startups emerge from stealth mode to ‘take on aging’

Nov 21, 2018

The Search for Mediators of Aging

Nov 1, 2018

Buck Institute donor tackles equality through fertility

Oct 23, 2018

MIT Technology Review profiles Judy Campisi and her research on cellular senescence

Aug 14, 2018

Three leaders in longevity biotechnology form a research collaboration

July 29, 2015

Buck Institute research suggests lithium may be effective in treating Parkinson’s disease

July 25, 2018

$6 million donation to help Buck Institute study extending age of women’s fertility

May 19, 2018

The Boston Globe does a feature piece on the field of aging research

Apr 26, 2018

Science VS podcast includes CEO Eric Verdin as it looks at the ketogenic diet

Apr 6, 2018

The Scientist covers research from the Andersen lab detailing a new way to look at Parkinson’s disease pathology

Apr 6, 2018

Reclassifying cancers to improve treatment – the BBC interviews Professor Chris Benz about major studies appearing in Cell

Mar 27, 2018

Buck faculty John Newman talks to Wired – The Science behind the pursuit of youth

Mar 14, 2018

Interview With Aging Expert Dr. Julie K. Andersen

Jan 28, 2018

Flushing out ‘zombie cells’ could help stave off Parkinson’s, study suggests

Jan 24, 2018

Cellular Senescence in Astrocytes May Play Central Role in Parkinson’s Disease

Here’s what’s happening

Upcoming events that feature Buck science

Ongoing

Formal Research Seminars

Click “read more” for full schedule

JAN 25, 2019

Paint the Town Red

Novato's 59th birthday party!

JAN 30, 2019

Marc Freedman on How to Live Forever

Buck hosts the Commonwealth Club

MAR 21, 2019

Ageless, by Bridgette Dutta Portman

Arts at the Buck – A reading of the speculative-fiction play: Ageless, or A Revolt of the Flesh

See all events

MEDIA CENTER

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Buck Institute @BuckInstitute·

Buck researchers show MANF is a rejuvenating factor in parabiosis. Publishing in @NatMetabolism, the Jasper lab harnesses the innate repair mechanism to protect against liver damage in aged mice and extend lifespan in flies. #livebetterlonger https://t.co/vbgG6CbIgn

Buck Institute @BuckInstitute·

We had a great time with the Girl Scouts @GSNorCal this weekend!! We love sharing the Buck with our community and even more when we get to encourage girls in science!! #livebetterlonger

Buck Institute @BuckInstitute·

How are obesity, aging, and #anxiety related? A recent @Cell_Metabolism study shows that obesity drives #senescence in brain glial cells and is associated with anxiety-like behaviors, which were alleviated by senescence clearance in mice. #livebetterlonger https://t.co/FmXYpdUKKH

Buck Institute @BuckInstitute·

An over-active immune system may be too much of a good thing. @NIH study in Drosophila suggests that downregulation of autophagy and hyperactivation of innate immunity results in neurodegeneration resembling human #Parkinsons disease. #livebetterlonger https://t.co/RolJQg3rHz

Buck Institute @BuckInstitute·

Genetics is a major risk factor for #Alzheimers, but can genes also be used to fight the disease? Buck professor Lisa Ellerby receives a $4.4 million @NIH grant to explore the protective role of ApoE2 in neurodegeneration. #livebetterlonger https://t.co/QG8ZDY1OXX

NEWS

From the bench to the boardroom

MANF identified as a rejuvenating factor in parabiosis

Exploiting a gene that protects against Alzheimer’s

Buck celebrates 30 years of research on aging with major symposium

A small foundation has a huge impact on Buck educational programs

Does dietary restriction protect against age-related leaky gut?

Running trails or genetic pathways: The future of exercise

Keep Calm and Research On: How to separate hype from fact in biomedical research

30 years and ongoing: Recap of the 30 years of aging research symposium

A perennial molecule that treats pellagra and pauses aging

Giving Tuesday: Why give to the Buck

Longevity: Is it all in the family?

Welcome to the inaugural edition of the Live Better Longer blog!

Bay Area seeing rush of research, investment in human longevity

Bay Area firm at forefront of science seeking arthritis cure

Buck Institute in Novato marks 30 years of aging research

Fountains of youth: Biotech startups emerge from stealth mode to ‘take on aging’

The Search for Mediators of Aging

Buck Institute donor tackles equality through fertility

MIT Technology Review profiles Judy Campisi and her research on cellular senescence

Three leaders in longevity biotechnology form a research collaboration

Event Highlights

Here’s what’s happening

Formal Research Seminars

Paint the Town Red

Marc Freedman on How to Live Forever

Ageless, by Bridgette Dutta Portman

MEDIA CENTER

Need more information about the Buck?

Keep up with the Buck