Mouse phenotyping

Expertise and technology that facilitates in vivo studies in mice.

Technology to drive breakthrough science

Over the past decade, in vivo phenotyping (IVP) technology has become a moving target, with advancements in imaging resolution, data collection, computational infrastructure, and informatics driving instrument development at an increasingly breakneck pace. The core instrumentation suite for IVP at the Buck Institute facilitates investigation of multiple endpoints for cross-sectional and longitudinal studies in mice. The core is becoming increasingly critical to Buck science as we transition to functional characterization of key organs and tissues of interest to aging research instead of merely characterizing lifespan, gene pathways, and histopathology as metrics of interest.

  • Simon Melov PhD . Co-Director
  • Lisa Ellerby PhD . Co-Director
  • B. K.
    Brian Kaplowitz . Research Associate

Please contact Brian Kaplowitz at BKaplowitz@buckinstitute.org to schedule runs on the instrumentation.

 

Brian Kaplowitz
Lab Technician
BKaplowitz@buckinstitute.org

Instrument  and vendor Modality Tissues/organs
1176 mCT (Bruker) X-ray microCT Multiple (with appropriate contrast)
Vevo 2100 (Visualsonics) High-frequency ultrasound Multiple (with appropriate contrast)
EchoMRI low-level X-ray Body composition
Promethion metabolic cages (x16) respirometry/activity/food/water Whole animal metabolism
Open field behavior Mouse behavior Whole body
Rotarod Mouse behavior Whole body
Muscle function (Aurora) In vivo evaluation of muscle function Hindlimb
Morris water maze Mouse behavior Whole body
Treadmill (endurance exercise) Forced running (air puff) Whole body
Radial arm maze Spatial learning and memory Whole body
Y maze Spatial learning and memory Whole body
Barnes Spatial learning and memory Whole body

Technological innovation in the service of scientific advancement

Our cutting-edge technologies support the Institute’s goals and put the newest capabilities in the
hands of our scientists.

Explore our core technologies