Expertise and technology that facilitates in vivo studies in mice.
Technology to drive breakthrough science
Over the past decade, in vivo phenotyping (IVP) technology has become a moving target, with advancements in imaging resolution, data collection, computational infrastructure, and informatics driving instrument development at an increasingly breakneck pace. The core instrumentation suite for IVP at the Buck Institute facilitates investigation of multiple endpoints for cross-sectional and longitudinal studies in mice. The core is becoming increasingly critical to Buck science as we transition to functional characterization of key organs and tissues of interest to aging research instead of merely characterizing lifespan, gene pathways, and histopathology as metrics of interest.
Simon Melov PhD . Co-Director
Lisa Ellerby PhD . Co-Director
Jubilee Ajiboye . Manager, Phenotyping Core
Sofiya Galkina . SRA, Phenotyping Core
Please contact Brian Kaplowitz at BKaplowitz@buckinstitute.org to schedule runs on the instrumentation.
|Instrument and vendor||Modality||Tissues/organs|
|1176 mCT (Bruker)||X-ray microCT||Multiple (with appropriate contrast)|
|Vevo 2100 (Visualsonics)||High-frequency ultrasound||Multiple (with appropriate contrast)|
|EchoMRI||low-level X-ray||Body composition|
|Promethion metabolic cages (x16)||respirometry/activity/food/water||Whole animal metabolism|
|Open field behavior||Mouse behavior||Whole body|
|Rotarod||Mouse behavior||Whole body|
|Muscle function (Aurora)||In vivo evaluation of muscle function||Hindlimb|
|Morris water maze||Mouse behavior||Whole body|
|Treadmill (endurance exercise)||Forced running (air puff)||Whole body|
|Radial arm maze||Spatial learning and memory||Whole body|
|Y maze||Spatial learning and memory||Whole body|
|Barnes||Spatial learning and memory||Whole body|
Technological innovation in the service of scientific advancement
Our cutting-edge technologies support the Institute’s goals and put the newest capabilities in the
hands of our scientists.