Technology to drive breakthrough science
Over the past decade, in vivo phenotyping (IVP) technology has become a moving target, with advancements in imaging resolution, data collection, computational infrastructure, and informatics driving instrument development at an increasingly breakneck pace. The core instrumentation suite for IVP at the Buck Institute facilitates investigation of multiple endpoints for cross-sectional and longitudinal studies in mice. The core is becoming increasingly critical to Buck science as we transition to functional characterization of key organs and tissues of interest to aging research instead of merely characterizing lifespan, gene pathways, and histopathology as metrics of interest.
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Simon Melov PhD . Co-Director -
Lisa Ellerby PhD . Co-Director -
Sofiya Galkina . Staff Scientist, Phenotyping CoreSGalkina@buckinstitute.org
Please contact Sofiya Galkina at sgalkina@buckinstitute.org to schedule runs on the instrumentation.
Sofiya Galkina: sgalkina@buckinstitute.org
Staff Scientist, Phenotyping Core
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INSTRUMENTS |
MODALITY AND PHENOTYPING PURPOSE |
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QUANTUM GX2 MICRO CT (PERKIN ELMER) |
CARDIOPULMONARY FUNCTION, FAT AND BONE CHARACTERISATION, ORGAN VOLUME, WITH CONTRAST SOFT TISSUE ANALYSIS (VOLUME) |
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VIVO 3100: ULTRASOUND (VISUALSONICS) |
ECHOCARDIOGRAPHY, RENAL AND HEPATIC IMAGING, THYROID AND TUMOR IMAGING, REPRODUCTIVE ORGAN IMAGING, VASCULAR PERFUSION AND IMAGING |
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LUMINA S5 IN VIVO IMAGING – IVIS (PERKIN ELMER) |
BIOLUMINESCENCE AND FLUORESCENT IMAGING |
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BODY COMPOSITION, NMR BASED (ECHO-MRI), NEW INSTRUMENTATION ARRIVING 4TH QUARTER (DEXA) |
BODY COMPOSITION ANALYSIS, MOUSE LEAN AND FAT MASS QUANTIFICATION |
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PROMETHION METABOLIC CAGES (SABLE SYSTEMS) |
WHOLE ANIMAL METABOLISM ANALYSIS; METABOLIC RATE QUANTIFICATION, FOOD AND WATER INTAKE, RESPIRATORY AND ENERGY ACTIVITY MONITORING |
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MOUSE MUSCLE PHYSIOLOGY (AURORA SCIENTIFIC) |
FORCE, FATIGUE, AND GENERAL FUNCTIONAL CHARACTERISATION |
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TRUSCAN – OPEN FIELD TEST |
GENERAL LOCOMOTOR, EXPLORATORY, AND ANXIETY METRICS |
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MOUSE TREADMILL |
MUSCLE PERFORMANCE AND EXERCISE CAPACITY, AND ENDURANCE METRICS |
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GRIP STRENGTH TEST |
NEUROMUSCULAR FUNCTION |
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ROTOROD TEST |
MOTOR COORDINATION AND BALANCE |
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NOVEL OBJECT RECOGNITION TEST |
MOUSE MEMORY AND LEARNING ABILITY |
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ELEVATED PLUS MAZE |
EXPLORATORY ACTIVITY AND ANXIETY LEVELS |
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Y MAZE |
RECOGNITION MEMORY AND SHORT-TERM MEMORY |
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MORRIS WATER MAZE |
LEARNING CAPACITY AND MEMORY |
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RADIAL ARM MAZE |
SPATIAL LEARNING AND MEMORY |
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FEAR CONDITIONONG TEST |
ASSOCIATIVE LEARNING AND CONDITIONED REACTION |
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BEAM CROSSING (BALANCE BEAMS) TEST |
SENSORINEURAL BALANCE, MOTOR FUNCTION, AND COORDINATION |
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OSMOTIC PUMP IMPLANTATION FOR DRUG DELIVERY |
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DRUG DELIVERY INJECTION (IV, IP, SQ, IM, ORAL GAVAGE) |
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TISSUE HARVESTING WITH/WITHOUT POSTMORTEM BLOOD COLLECTION |
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CORE TECHNOLOGIES
Technological innovation in the service of scientific advancement
Our cutting-edge technologies support the Institute’s goals and put the newest capabilities in the
hands of our scientists.