Mouse phenotyping

Expertise and technology that facilitates in vivo studies in mice.

Technology to drive breakthrough science

Over the past decade, in vivo phenotyping (IVP) technology has become a moving target, with advancements in imaging resolution, data collection, computational infrastructure, and informatics driving instrument development at an increasingly breakneck pace. The core instrumentation suite for IVP at the Buck Institute facilitates investigation of multiple endpoints for cross-sectional and longitudinal studies in mice. The core is becoming increasingly critical to Buck science as we transition to functional characterization of key organs and tissues of interest to aging research instead of merely characterizing lifespan, gene pathways, and histopathology as metrics of interest.

  • Simon Melov PhD . Co-Director
  • Lisa Ellerby PhD . Co-Director
  • Sofiya Galkina . Staff Scientist, Phenotyping Core

    SGalkina@buckinstitute.org

Please contact Sofiya Galkina at sgalkina@buckinstitute.org to schedule runs on the instrumentation.

 

Sofiya Galkina:  sgalkina@buckinstitute.org
Staff Scientist, Phenotyping Core

INSTRUMENTS

MODALITY AND PHENOTYPING PURPOSE

 QUANTUM GX2 MICRO CT

(PERKIN ELMER)

 CARDIOPULMONARY FUNCTION, FAT AND BONE CHARACTERISATION, ORGAN VOLUME, WITH CONTRAST SOFT TISSUE ANALYSIS (VOLUME)

VIVO 3100: ULTRASOUND

(VISUALSONICS)

ECHOCARDIOGRAPHY, RENAL AND HEPATIC IMAGING, THYROID AND TUMOR IMAGING, REPRODUCTIVE ORGAN IMAGING, VASCULAR PERFUSION AND IMAGING

LUMINA S5 IN VIVO IMAGING – IVIS (PERKIN ELMER)

BIOLUMINESCENCE AND FLUORESCENT IMAGING

BODY COMPOSITION, NMR BASED

(ECHO-MRI), NEW INSTRUMENTATION ARRIVING 4TH QUARTER (DEXA)

BODY COMPOSITION ANALYSIS, MOUSE LEAN AND FAT MASS QUANTIFICATION

PROMETHION METABOLIC CAGES

(SABLE SYSTEMS)

WHOLE ANIMAL METABOLISM ANALYSIS; METABOLIC RATE QUANTIFICATION, FOOD AND WATER INTAKE, RESPIRATORY AND ENERGY ACTIVITY MONITORING

MOUSE MUSCLE PHYSIOLOGY (AURORA SCIENTIFIC)

FORCE, FATIGUE, AND GENERAL FUNCTIONAL CHARACTERISATION

TRUSCAN – OPEN FIELD TEST

GENERAL LOCOMOTOR, EXPLORATORY, AND ANXIETY METRICS

MOUSE TREADMILL

MUSCLE PERFORMANCE AND EXERCISE CAPACITY, AND ENDURANCE METRICS

GRIP STRENGTH TEST

NEUROMUSCULAR FUNCTION

ROTOROD TEST

MOTOR COORDINATION AND BALANCE

NOVEL OBJECT RECOGNITION TEST

MOUSE MEMORY AND LEARNING ABILITY

ELEVATED PLUS MAZE

EXPLORATORY ACTIVITY AND ANXIETY LEVELS

Y MAZE

RECOGNITION MEMORY AND SHORT-TERM MEMORY

MORRIS WATER MAZE

LEARNING CAPACITY AND MEMORY

RADIAL ARM MAZE

SPATIAL LEARNING AND MEMORY

FEAR CONDITIONONG TEST

ASSOCIATIVE LEARNING AND CONDITIONED REACTION

BEAM CROSSING (BALANCE BEAMS) TEST

SENSORINEURAL BALANCE, MOTOR FUNCTION, AND COORDINATION

OSMOTIC PUMP IMPLANTATION FOR DRUG DELIVERY

 

DRUG DELIVERY INJECTION (IV, IP, SQ, IM, ORAL GAVAGE)

 

TISSUE HARVESTING WITH/WITHOUT POSTMORTEM BLOOD COLLECTION

 

Technological innovation in the service of scientific advancement

Our cutting-edge technologies support the Institute’s goals and put the newest capabilities in the
hands of our scientists.

Explore our core technologies