CENTER FOR REPRODUCTIVE LONGEVITY AND EQUALITY
While aging research is seeing unprecedented acceleration, how and why women undergo a decline in reproductive function with age is understudied. Thanks to a significant gift from Nicole Shanahan, the Buck has established the Center for Reproductive Longevity and Equality (CRLE). This is the first facility anywhere in the world focused solely on reproductive longevity and equality as it relates to aging and ending the threat of age-related disease.
Our goal is to conduct basic research to understand the mechanisms of female reproductive aging and develop strategies to prevent or delay ovarian aging. The end of fertility sets off a cascade of negative health effects in women’s bodies that impact bone, cognitive, cardiovascular and immune function. We want to understand why human women undergo a decline in fertility (menopause), why it varies between individuals, and why it correlates with life span. We think that understanding the limits on mammalian female reproductive capacity may provide important clues about aging in other tissues, as many hallmarks of aging are shared between somatic cells and oocytes. We collaborate with research groups around the world and promote open access data sharing.
Lei Lei, PhD Scientific Director and Associate Professor
Shiying Jin, PhD Assistant Professor
Jennifer Garrison, PhD Assistant Professor
Francesca Duncan, PhD Assistant Professor in Residence
Polina Lishko, PhD Adjunct Associate Professor
Deena Emera, PhD Writer in Residence
Melissa Cordeiro CRLE Program Coordinator
With the establishment of the Center for Reproductive Longevity and Equality (CRLE) at the Buck Institute, we’ve pioneered the first facility that focuses solely on female aging as it relates to equality. Now, in collaboration with the Bia Echo Foundation, the Global Consortium for Reproductive Longevity and Equality (GCRLE) is soliciting applications from investigators worldwide for two-year projects focused broadly on understanding female reproductive aging to support this exciting new field.