Our focus is aging
While aging research is seeing unprecedented acceleration, the area of women’s reproductive longevity has remained underappreciated. Thanks to a significant gift from Nicole Shanahan, the Buck is establishing the Center for Female Reproductive Longevity and Equality. This will be the first facility anywhere in the world focused solely on reproductive equality and longevity as it relates to aging and ending the threat of age-related disease.
Results from some recent small investigational studies suggest that there are several potential molecular mechanisms contributing to ovarian aging, including impaired DNA repair, metabolic/energetic disorders, and mitochondrial dysfunction. We are looking forward to building on these preliminary findings to further the understanding of the mechanisms of reproductive senescence and potentially develop strategies to prevent or delay ovarian aging.
