Live better longer.

Working to create a world where everyone can have
healthy minds and healthy bodies at every age.

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A mission-driven community
of investigators

The Buck is a collective of the world’s top scientists in the field of aging who are sharing their methods and
expertise to find ways to help everyone lead fuller, healthier lives by ending age-related disease.

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Advancing the frontiers
of research on aging

Using cutting-edge science to tackle aging, the #1 risk factor for chronic disease.

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Our mission is to end the threat of age-related disease for this and future generations

We believe it is possible for people to enjoy their lives at 95 as much as they do at 25, and to achieve that, we’re seeking a more comprehensive understanding of the biology of aging itself.

Advancing the frontiers
of aging research

Using cutting-edge science to tackle aging, the #1 risk factor for chronic disease.

Buck researchers uncover intriguing connection between diet, eye health and lifespan

Buck researchers uncover an intriguing connection between diet, eye health and lifespan in Drosophila

Buck Scientists Highlight New Perspective in How Immunity is Fine-Tuned through Mechanics

Introducing a new scientific discipline: Mechanoimmunlogy

Ketone bodies: Likely good for aging—and maybe for the military too

Lead Translational Scientist Brianna Stubbs explains the Buck’s role in a major study

“What I want people to know about the Buck is the incredible commitment and excitement that permeates the walls of this institution. We are pushing the frontiers in an area that is going to impact all of humanity. I cannot tell you exactly when this will happen, but I can tell you big discoveries will come out of the Buck.”

Eric Verdin, MD, Buck Institute President and CEO

The Buck’s Impact Circle supports a first-ever pilot study to look at the effects of a ketogenic supplement in older adults

This year the Buck’s Impact Circle chose to support the first-ever clinical study to be done at the Buck Institute.

Buck Institute scientists uncover a new role for blood-brain barrier in neuron function and damage

Findings open up a potential new avenue for therapies aimed at countering neurodegeneration

A naturally-occurring metabolite is a potent senolytic in both mice and human cell culture

25-hydroxycholesteral shows particular efficacy in skeletal muscle
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Here’s what’s happening

Upcoming events at the Buck

Service Animal Accommodation

Formal Research Seminars

FRS talks are being held via Zoom by invitation only.

Fat cells that grow in close proximity to breast cancers can shift into other cell types creating ‘fertile soil’ that promotes tumor growth. Study in @CellReports helps explain why #obesity is a risk factor for #breastcancer occurrence and worst prognosis

An unhealthy gut sets stage for metastatic breast cancer. Research in @AACR shows ailing microbiome reprograms mast cells in healthy breast tissue to facilitate cancer spread. Study in mice and human tissue could lead to treatments to ID those at risk.

If killer #Tcells get better with age, why are older adults more susceptible to cancer and viruses? Study in @AgingCell suggests that the deteriorating immune response is not to be found in T cells themselves but rather in their aging environment.

High-fat diets trigger the generation of inflammatory immune cells in the bone marrow of mice. Study in @eLife shows metabolic disturbances occur in bone within three weeks of the diet, making mitochondria less efficient.

We love our Postdocs!! They are the foundation of our science. Whether speaking of the work we do, the output we deliver, or the breakthroughs we are all striving for, none would be possible without the postdocs in our labs. #PostdocAppreciationWeek #livebetterlonger

Visit the
Buck Institute

Come and share in the excitement. Our doors are open, and we love talking about our science.

Join the fight against age-related diseases

You don’t have to be a scientist to make an important contribution to research on aging. We rely on donations to support the science that we believe will add years to people’s lifespan and decades to their healthspan.

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