Live better longer.

Working to create a world where everyone can have
healthy minds and healthy bodies at every age.

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A mission-driven community
of investigators

The Buck is a collective of the world’s top scientists in the field of aging who are sharing their methods and
expertise to find ways to help everyone lead fuller, healthier lives by ending age-related disease.

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Advancing the frontiers
of research on aging

Using cutting-edge science to tackle aging, the #1 risk factor for chronic disease.

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Check out our
new podcast!

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Our mission is to end the threat of age-related disease for this and future generations

We believe it is possible for people to enjoy their lives at 95 as much as they do at 25, and to achieve that, we’re seeking a more comprehensive understanding of the biology of aging itself.

Advancing the frontiers
of aging research

Using cutting-edge science to tackle aging, the #1 risk factor for chronic disease.

Ketone bodies: more than energy, they are powerful signaling metabolites that clean up damaged proteins

Ketone esters help clear misfolded proteins in mouse models of aging and Alzheimer’s disease   Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production...

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Crunching fruit fly and human data via machine learning reveals key metabolites that impact lifespan in both species

Study suggests that threonine may hold promise as therapeutic target for aging Discoveries that impact lifespan and healthspan in fruit flies are usually tested in mice before being considered potentially relevant in humans, a process that is expensive and time intensive...

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Excited about participating in our clinical trials?

Here’s what you need to know about our Clinical Research Core, Part 2

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“What I want people to know about the Buck is the incredible commitment and excitement that permeates the walls of this institution. We are pushing the frontiers in an area that is going to impact all of humanity. I cannot tell you exactly when this will happen, but I can tell you big discoveries will come out of the Buck.”

Eric Verdin, MD, Buck Institute President and CEO

Health AI Expert Nathan Price Joins Buck Faculty

Price will also co-direct the Center for Human Healthspan

Buck researchers explore how the immune system goes awry during space travel and the implications for human aging on Earth

Findings provide insight into interventions to maintain normal immunity in space and during aging on the ground

How the Ketogenic Diet Improves Healthspan and Memory in Aging Mice

The insight into mechanisms provides new targets for improving memory that may not even require a ketogenic diet
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Here’s what’s happening

Upcoming events at the Buck

Service Animal Accommodation
Ongoing

The James A. Aleveras Formal Research Seminars

Ongoing

Docent-led Buck Tour

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Visit the
Buck Institute

Come and share in the excitement. Our doors are open, and we love talking about our science.

Join the fight against age-related diseases

You don’t have to be a scientist to make an important contribution to research on aging. We rely on donations to support the science that we believe will add years to people’s lifespan and decades to their healthspan.

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