The Buck Institute is the nation’s first and foremost non-profit research organization devoted to Geroscience, which is focused on the connection between normal aging and chronic disease. Our creative, interdisciplinary approach involves collaborations between laboratories studying:

  • The mechanisms of aging
  • Age-related diseases
  • Stem cell technologies and regenerative medicine

Buck scientists strive to discover new ways of detecting, preventing, delaying and treating age-related conditions such as Alzheimer’s and Parkinson’s, cancer, cardiovascular disease, macular degeneration, diabetes and stroke.

Recent Publications:
  • "Glucocorticoids Suppress Selected Components of the Senescence-Associated Secretory Phenotype." Aging cell
  • "Ubiquitin Specific Peptidase 9, X-linked (USP9X) Modulates the Activity of Mammalian Target of Rapamycin (mTOR)." The Journal of biological chemistry
  • "Proteomic Analysis of Age-dependent Changes in Protein Solubility Identifies Genes that Modulate Lifespan." Aging cell 11:1 120-7
More publications from the Hughes Lab...
Core Technologies:
Bioinfomatics >
Chemistry & Spectrometry >
Genomics >
Morphology & Imaging >
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