The mammalian female reproductive function declines dramatically during aging, reflected by germ cell pool loss, reduced ovarian endocrine function and inclination to uterine cancer development. The Jin lab uses mouse and human models to understand and tackle these problems. First, we are interested in fertility preservation before aging initiation, in which young oocytes can be protected and stored for later use. A solution in mice to preserve young germ cells has been developed by engineering ovarian tissue. The long-term effort is to establish an effective strategy in humans. Second, we have recently identified a uterine stem cell population by single-cell lineage tracing in mice, a cellular source for the uterine homeostasis and regeneration. Further work in the Jin lab is to reveal the relationship between the dysfunction of uterine stem cells or their niche driven by aging and gynecological diseases like cancer and endometriosis. A stem-cell-based therapeutic strategy may be developed. By collaborating with Buck researchers, we also want to apply our knowledge to the question: how reproductive aging impacts other organ’s aging like the brain in females.
Why it matters
Female aging initiates in the reproductive system then spreads to the whole body. This gender specific aging calendar creates severe health challenges to women. Thus, reproductive health and longevity sets the first key step to women’s wellness.
We are driven by a mission to improve women’s reproductive health, longevity and equality to research ovarian and uterine function and aging.
Shiying Jin, PhD
Dr. Jin is an assistant professor in the Center for Female Reproductive Longevity and Equality within Buck Institute for Research on Aging. He received his Ph.D. in reproductive physiology from the China Agricultural University in Beijing. He then had postdoctoral training in reproductive, developmental and stem cell biology at Northwestern University in Chicago as well as in the Department of Embryology, Carnegie Institution for Science in Baltimore. Dr. Jin identified uterine stem cells in mice. He was awarded the first generation of Oncofertility Globally Ready Scholar by the National Institute of Health to study female fertility preservation.
Heather Tanner Research Associate and Lab Manager
Heather obtained her BA degree in anthropology from Western Michigan University. She then worked as an archaeologist across the United States moving to York in the United Kingdom to pursue and complete a MA in landscape archaeology. Deciding to change research objectives, Heather moved to Boston, MA in the United States where she conducted her Master thesis work on the placebo effect in Dr. Emmanuel Pothos’ neuroscience laboratory. In Boston, she mastered brain slice and amperometry electrophysiology technique and mammalian cell culture to observe the placebo effect on the rat central nervous system. Her passion for finding drug candidates and her interest in the reproductive system led her to her first benchwork position in Dr. Lei Lei’s laboratory at the University of Michigan, which she followed to the Buck Institute. Here she researches how and why cytokinesis is interrupted during oogenesis with mouse models. She enjoys water sports, running/walking with her dog Daisey, admiring and making art, and archaeology.
- Shiying Jin. 2019. Bipotent stem cells support the cyclical regeneration of endometrial epithelium of the murine uterus. Proceedings of the National Academy of Sciences. 116:6848-6857.
- Shiying Jin, David Martinelli, Xiaobin Zheng, Marc Tessier-Lavigne, Chen-Ming Fan. 2015. Gas1 is a receptor for Sonic Hedgehog to repel enteric axons. Proceedings of the National Academy of Sciences. 112:73-80.
- Shiying Jin, Lei Lei, Ariella Shikanov, Lonnie D. Shea, Teresa K. Woodruff. 2010. A novel two-step strategy for in vitro culture of early-stage ovarian follicles in the mouse. Fertility and Sterility. 93:2633-2639.
- Shiying Jin, Lei Lei, Lonnie D Shea, Mary B Zelinski, Richard L Stouffer, Teresa K Woodruff. 2010. Markers of growth and development in primate primordial follicles are preserved after slow cryopreservation. Fertility and Sterility. 93:2627-32.
- Shiying Jin, Meijia Zhang, Lei Lei, Chao Wang, Maoyong Fu, Gang Ning, Guoliang Xia. 2006. Meiosis activating sterol (MAS) regulates FSH-induced meiotic resumption of cumulus cell-enclosed porcine oocytes via PKC pathway. Molecular and Cellular Endocrinology. 249:64-70.
- Chen H, Jin S, Guo J, Kombairaju P, Biswal S, Zirkin BR. 2015. Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells. Molecular and Cellular Endocrinology. 409:113-20.
Shiying Jin’s Pubmed link