How cellular senescence could help stop the scourge of Alzheimer’s, cancer and other chronic diseases

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$27 million in federal grants propels the Buck’s pioneering research in cellular senescence as the NIH looks to research in aging to stop the scourge of Alzheimer’s, cancer and other chronic diseases

Recent awards from the NIH are moving the Buck’s already-stellar research of cellular senescence, which leads to a process called “inflammaging,” into new realms of discovery, including efforts to prevent and treat Alzheimer’s disease. Join us to find out how this influx of support is impacting our efforts to help all of us live better longer.

The science: Cellular senescence is a stress response that can lead to chronic low-level inflammation throughout our bodies.  Dubbed “inflammaging,” this phenomena has been linked to diseases as varied as Alzheimer’s, osteoarthritis, macular degeneration and cancer.  

The tantalizing possibility: Taming cellular senescence could allow us to tackle almost every age-related disease!

Join us for a conversation with the three Buck Institute professors who are leading these new research projects.


Webinar Event Registration

December 9, 2021
11:00 am - 12:00 pm PT
We will send out a zoom link the day before your scheduled session, and a reminder email the morning of the session.

Dr. Judy Campisi

Professor Judith Campisi is recognized internationally as a pioneer in studies of cellular senescence and is a principal investigator on all of the new grants. A member of the National Academy of Sciences, Campisi is a scientific co-founder of Unity Biotechnology which is running clinical trials of a senolytic drug aimed at treating macular degeneration.  


Dr. Lisa Ellerby

Professor Lisa Ellerby is a neuroscientists who is a co-principle investigator of a $14 million grant aimed at studying cellular senescence and Alzheimer’s disease. Her team will derive various brain cells from induced pluripotent stem cells, including those from patients who had Alzheimer’s. Ellerby’s team will also grow brain organoids, so-called “mini brains” that recapitulate the cellular integrity, structure and function of the brain.


Dr. Birgit Schilling

Associate professor Birgit Schilling brings expertise in mass spectrometry and proteomics to many projects at the Buck. She is a co-principal investigator of a $12.7 million grant which gets the Buck into the NIH’s Cellular Senescence Network, a national “tissue and cell mapping” project involving 13 research institutes. Schilling’s team will help identify and characterize senescent cells in human ovaries, breast tissue and skeletal muscle. 

The conversation will be moderated by Kris Rebillot, Senior Director of Communications. There will be time for your questions.

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