David G. Nicholls, PhD, Professor

Mitochondrial function and the life and death of cells

David Nicholls has researched mitochondrial function for 45 years and has more than 280 publications. He is perhaps best known as the author (now with Stuart Ferguson) of the standard textbook ‘Bioenergetics’, for his discovery of the original uncoupling protein, UCP1, for work on mitochondrial calcium transport and isolated nerve terminals and most recently for his research into mitochondrial dysfunction in nerve cells.

He established the Bioenergetics laboratory at the Buck in 2000 before handing it over to Martin Brand in 2008. He retains a part-time position in the Institute and spends 3-4 months a year there at the bench helping to develop novel techniques to investigate in situ mitochondrial bioenergetics. For the rest of the year he is based in Lund, Sweden and travels extensively in Europe lecturing and teaching.

Dr. Nicholls received his Ph.D., in Biochemistry from the University of Bristol, England. He is a Fellow of the Royal Society of Edinburgh and holder of the 2008 Mitchell Memorial Medal from the European Bioenergetics Congress.

dnicholls@buckinstitute.org
Phone: 415-209-2095
Research Support Manager: Eduardo Meza
emeza@buckinstitute.org
Phone: 415-209-2082
Fax: 415-209-2232

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Recent Publications

2012

David G Nicholls, ... David G Nicholls "Fluorescence measurement of mitochondrial membrane potential changes in cultured cells." Methods Mol. Biol. 810 119-33
Isabel Goehring, Akos A Gerencser... David G Nicholls "Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells do not Require Glycolysis and are not Initiated by Fluctuations in Mitochondrial Bioenergetics." The Journal of biological chemistry 287:19 15706-17
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