Lithgow Lab Members

Gordon Lithgow
Professor

Suzanne Angeli
Joint Postdoctoral Fellow

Suzanne Angeli is a joint postdoctoral fellow in the Lithgow and Andersen labs. She received her PhD from the University of California, San Francisco, where she studied protein misfolding in polyglutamine diseases, a class of neurodegenerative diseases. For her postdoc, Suzanne is investigating how aging, genetics, and metals work in synergy to lead to Parkinsons disease onset using C. elegans as a model.

Dipa Bhaumik
Staff Scientist

Dipa completed her PhD in Biochemistry in University, in Calcutta, India. Prior to coming to the Buck Institute, she held fellowships at the University of North Carolina at Chapel Hill, Stanford University, Calcutta University, and the University of Pennsylvania. Dipa's primary job in the Lithgow lab is to manage the lab and assist in the research of other lab members. Her own research project involves testing the effect of different natural products on C. elegans life span.

Kathleen Dumas
Glenn Foundation Research Training Scholar

Ida Klang
Graduate Student

Ida is a graduate student in the Lithgow lab through collaboration with the Karolinska Institute in Sweden. Ida is studying the role of metal homeostasis with age in C. elegans and is also looking at compounds that could stabilize the metal profile with age.

Mark Lucanic
Postdoctoral Research Fellow

The goal of Mark's work at the Buck Institute is to identify and characterize new genes, molecules and pathways that are active in lifespan determination. His method of choice has been to employ small molecule screens that elicit or resolve phenotypes related to lifespan or age related diseases in the model organism C. elegans. Through the use of these screens, Mark and other Lithgow lab members have recently identified and characterized a conserved signaling pathway which directly links an organisms’ diet to its lifespan. Currently, he has been focusing on a new group of hits from a large scale screen for potential drugs that can extend lifespan. These new compounds all contain similar molecular structures and extend lifespan through perturbing the animals’ ability to detect critical aspects of their bacterial food. Through the characterization of these compounds effects on C. elegans, we are discovering novel mechanisms for how animals experience nutrients and correspondingly alter their physiology to extend their lifespan.

Karla Mark
Postdoctoral Research Fellow

Karla completed her PhD in Pharmacology in Bryan Yamamoto’s lab at Boston University School of Medicine.  Karla’s thesis involved determining the underlying mechanisms of methamphetamine (METH)-induced damage to rat striatal dopaminergic nerve terminals in vivo.  These mechanisms share many common factors associated with other neurological diseases, and have been the basis of her training and research interests.  In the Lithgow lab, she is focusing on understanding the role of protein aggregation in aging processes and using C. elegans as a model system.

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