Juliette Gafni, Theodora Papanikolaou... Lisa M Ellerby "Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment."The Journal of neuroscience : the official journal of the Society for Neuroscience 32:22 7454-7465
Melissa R Sarantos, Theodora Papanikolaou... Robert E Hughes "Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease."J Huntingtons Dis 1:2 195-210
John P Miller, Bridget E Yates... Robert E Hughes "A Genome-Scale RNA-Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease."PLoS Genet. 8:11 e1003042
Daniel J Klionsky, Fabio C Abdalla... "Guidelines for the use and interpretation of assays for monitoring autophagy."Autophagy 8:4 445-544
Ying Zou, Ningzhe Zhang... Pierre-Yves Desprez "Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation."Biochem. Biophys. Res. Commun. 426:1 100-5
Mahru C An, Ningzhe Zhang... Lisa M Ellerby "Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells."Cell stem cell 11:2 253-63
Ningzhe Zhang, Bensheng Li... Lisa M Ellerby "Inhibition of lipid signaling enzyme diacylglycerol kinase {varepsilon} attenuates mutant Huntingtin toxicity."The Journal of biological chemistry 287:25 21204-13
2011
Xin Cong, Jason M Held... Lisa M Ellerby "Mass spectrometric identification of novel lysine acetylation sites in huntingtin."Molecular & cellular proteomics : MCP 10:10 M111.009829
2010
Melissa J Leyva, Francesco Degiacomo... Jonathan A Ellman "Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models."Chem. Biol. 17:11 1189-200
John P Miller, Jennifer Holcomb... Lisa M Ellerby "Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease."Neuron 67:2 199-212
Carlotta Duncan, Theodora Papanikolaou... Lisa M Ellerby "Autophagy: polyQ toxic fragment turnover."Autophagy 6:2 312-4
Christian Landles, Kirupa Sathasivam... Gillian P Bates "Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease."J. Biol. Chem. 285:12 8808-23
Ningzhe Zhang, Mahru C An... Lisa M Ellerby "Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells."PLoS Curr 2 RRN1193
2009
Shona Mookerjee, Theodora Papanikolaou... Lisa M Ellerby "Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment."J. Neurosci. 29:48 15134-44
Juliette Gafni, Xin Cong... Lisa M Ellerby "Calpain-1 cleaves and activates caspase-7."J. Biol. Chem. 284:37 25441-9