Akos Gerencser, PhD

Assistant Director of the Morphology and Imaging Core

Dr. Akos Gerencser's dual background in medicine and biomedical engineering allows a unique vantage point on measurement technology and modeling of biological processes. He is experienced in mitochondria- and cell physiology-related, fluorescence microscopy-based technique development. He has designed the oxygen consumption rate calibration algorithm of the Seahorse Extracellular Flux Analyzer “(LEVEL) Direct (AKOS)”. He has developed a set of image processing technologies specifically designed for quantification of mitochondrial calcium, shape changes and motion in fluorescence microscopy recordings. These tools are available to the public in the Image Analyst MKII image processing software. He has studied the role of mitochondrial dynamics in neuronal apoptosis and neurodegeneration, and for the past five years bioenergetics and mitochondrial dysfunction in neurodegenerative disease models and mechanisms of insulin secretion in pancreatic beta cell models. His current interest is the development of mitochondrial membrane potential assays that report potentials in absolute millivolts independently of the plasma membrane potential and geometric factors. This will allow the comparison of different cell types and conditions, together with the Seahorse technology enabling a comprehensive characterization of oxidative energy metabolism in aging and disease models.

As Assistant Director of the Morphology and Imaging Core, Akos Gerencser, PhD, is available to discuss high-level imaging collaborative ideas, particularly live cell imaging, deep tissue imaging, and multispectral imaging.

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