Brand Lab Members

Martin Brand

Akos Gerencser
Assistant Research Professor

His dual background in medicine and biomedical engineering allows a unique vantage point on measurement technology and modeling of biological processes. He is experienced in mitochondria- and cell physiology-related, fluorescence microscopy-based technique development. He has designed the oxygen consumption rate calibration algorithm of the Seahorse Extracellular Flux Analyzer “(LEVEL) Direct (AKOS)”. He has developed a set of image processing technologies specifically designed for quantification of mitochondrial calcium, shape changes and motion in fluorescence microscopy recordings. These tools are available to the public in the Image Analyst MKII image processing software. He has studied the role of mitochondrial dynamics in neuronal apoptosis and neurodegeneration, and for the past five years bioenergetics and mitochondrial dysfunction in neurodegenerative disease models and mechanisms of insulin secretion in pancreatic beta cell models. His current interest is the development of mitochondrial membrane potential assays that report potentials in absolute millivolts independently of the plasma membrane potential and geometric factors. This will allow the comparison of different cell types and conditions, together with the Seahorse technology enabling a comprehensive characterization of oxidative energy metabolism in aging and disease models.

Renata Goncalves
Postdoctoral Research Scholar

Renata received her PhD in Biological Chemistry at Federal University of Rio de Janeiro, Brazil (2010). As a post Doctoral fellow she seeks to understand mitochondrial dysfunction and ROS generation after immune challenges in invertebrates.

Shona Mookerjee
Adjunct Assistant Professor

Shona received her degree in Molecular Genetics from the University of Rochester in 2006. Her graduate work involved identifying and characterizing mechanisms of mitochondrial DNA repair in the budding yeast Saccharomyces cerevisiae. During her first post-doc in the Ellerby Lab at the Buck Institute, she studied the regulation of the polyglutamine-containing protein ataxin-7 by post-translational modification. In her current post-doc in the Brand Lab, she is investigating the mitochondrial uncoupling proteins UCP2 and UCP3, and their regulation by rapid turnover.

Adam Orr
Staff Scientist

Adam received his PhD in Neuroscience from Emory University. He is interested in the mechanisms of reactive oxygen species (ROS) production and mitochondrial dysfunction in the context of age-related diseases. He utilizes a nondiscrimination policy for his research on site-specific ROS production and a goal of identifying novel investigative tools and therapeutic agents for the targeted modulation of mitochondrial bioenergetics.

Irina Perevoshchikova
Glenn Foundation Research Training Fellow

Irina received her PhD from the State University of Moscow. She studies sites and mechanisms of reactive oxygen species production in mitochondria, with a particular emphasis on fatty acid oxidation in muscle.

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