Greenberg Lab
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David A. Greenberg, M.D., Ph.D., Professor and V.P. for Special Research Programs

Stem cell and regenerative medicine approaches to stroke and neurodegeneration

The Greenberg lab studies ways in which the brain protects itself from and repairs injury. Lab members investigate brain injury produced by stroke and neurodegenerative diseases, seeking to identify molecular and cellular mechanisms of self-repair. The ultimate goal is to adapt the brain’s own repair processes to design new therapies for neurological disease. In the past year, efforts have focused on the development and use of transgenic animal models of human neurological disease. For example, mice that overexpress vascular endothelial growth factor (VEGF) have been used to study the neuroprotective potential of VEGF. These studies have shown that VEGF improves tissue pathology and clinical course in a mouse model of amyotrophic lateral sclerosis (Lou Gehrig’s disease) and promotes recovery following stroke in mice. The lab has also developed a transgenic mouse that overexpresses neuroglobin (Ngb), another neuroprotective protein. Ngb‑overexpressing transgenic mice are resistant to interruption of blood flow (ischemia) in the brain and heart, suggesting a potential protective role for Ngb in both stroke and heart attack.

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