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Curriculum vitae

Sirkka Liisa Hostikka, Ph.D.

Education and Training

  • 1980 - 1984 B.S., Biochemistry, University of Oulu, Finland
  • 1980 - 1987 M.Sc., Biochemistry, University of Oulu, Finland.
  • 1985 - 1991 Ph.D., Biochemistry, University of Oulu, Finland.
  • Thesis: "Human Type IV Collagen. Characterization of the α2(IV) chain and 3' end of its gene, and identification of a novel α5(IV) chain with mutations in Alport syndrome.” Acta Universitatis Ouluensis A 212 (1990).
    Prof. Karl Trygvason
  • 1991 - 2000 Post-doctoral fellow / Research associate, Howard Hughes Medical Institute and Department of Human Genetics, University of Utah, Salt Lake City, Utah. The function of AbdB-like Hox genes in limb and urogenital development and reproduction. Developmental biology study of the gene function through knockout phenotypic analysis.
    Advisor: Prof. Mario R. Capecchi
  • 2009 Post-doctoral fellow, Buck Institute for Age Research, Novato, CA
    Advisor: Prof. Victoria Lunyak

Additional Professional Experience

  • 1987 Instructor: Basic molecular biology laboratory course for senior investigators. Teaching booklet: Hostikka, S.L., Huhtala, P., Kallunki, P. and Vuolteenaho, R. (1987) Geenitekniikan peruskurssi. Biocenter Oulu/ Oulun yliopiston täydennyskoulutuskeskus, University of Oulu.
  • 1995 Invited speaker: Advanced course: Recent progress in developmental biology using invertebrate, vertebrate and plant model systems. At Biotechnology and molecular biology graduate school, Biocenter Oulu, Oulu, Finland and Graduate school at Institute of Biotechnology, Helsinki, Finland.
  • 2000 - 2001 Application Scientist, Combimatrix Corporation, Mukilteo, WA
  • 2002 - 2004 Staff Scientist, Pacific Northwest Research Institute, Seattle, WA.
  • 2005 - 2007 Research Scientist, University of Washington, Seattle, WA.

Awards and grants

  • 1988-1990 Pre-doctoral Molecular Biology Training grant award, Academy of Finland
  • 1990 Grant, Emil Aaltonen Foundation
  • 1991 Post doctoral Young Investigator, Academy of Finland
  • 1991 Grant, Finnish cultural foundation
  • 1991-1993 Post-doctoral fellowship, Sigrid Juselius Foundation
  • 1994 Primus doctorate, Faculty of Science, University of Oulu; Doctor primus rerum naturalium facultatis, Universitatis Ouluensis
  • 1994 - 1996 Associate of the Howard Hughes Medical Institute

Original Publications

  • Hostikka SL, Kurkinen M, Tryggvason K. Nucleotide sequence coding for the human type IV collagen α2 chain cDNA reveals extensive homology with the NC-1 domain of α1 (IV) but not with the collagenous domain or 3' untranslated region. FEBS Lett. 1987; 216: 281-286.
  • Hostikka SL, Tryggvason K. Extensive structural differences between genes for the α1 and α2 chains of type IV collagen despite conservation of coding sequences. FEBS Lett. 1987; 224: 297-305.
  • Hostikka SL, Tryggvason K. The complete primary structure of the α2 chain of type IV collagen and comparison with the α1(IV) chain. J. Biol. Chem. 1988; 263: 19488-19493.
  • Soininen R, Huotari M, Hostikka SL, Prockop DJ, Tryggvason K. The structural genes for α1 and α2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. J. Biol. Chem. 1988; 263: 17217-17220.
  • Hostikka SL, Eddy RL, Byers MG, Höyhtyä M, Shows TB, Tryggvason K. Identification of a distinct type IV collagen α5 chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome. Proc. Natl. Acad. Sci. USA 1990; 87: 1606-1610.
  • Barker DF, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, Tryggvason K. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990; 248: 1224-1227.
  • Zhou J, Hostikka SL, Chow LT, Tryggvason K. Characterization of the 3' half of the human type IV collagen α5 gene which is affected in Alport syndrome. Genomics 1991; 9: 1-9
  • Zhou J., Barker DF, Hostikka SL, Gregory MC, Atkin CL, Tryggvason K. Single base mutation in the α5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome. Genomics 1991; 9: 10-18.
  • Smeets HJM, Melenhorts JJ, Lemmink HH, Schröder CH, Nelen MR, Zhou J, Hostikka SL, Tryggvason K, Ropers H-H, Janweijer MCE, Monnens LAH, Brunner HG, van Oost BA. Mutations in the COL4A5 collagen gene leading to different types of Alport syndrome. Kidney Int. 1992; 42: 83-88.
  • Sariola H, Hostikka SL, Lukkarila S, Tryggvason K. Distribution of type IV collagen α1, α2 and α5 chains in human tissues. In: Molecular Pathology and Genetics of Alport Syndrome. (K. Tryggvason, ed.) S. Karger AAG, Basel, 1996; 117, 130-141.
  • Hostikka SL, Capecchi MR. The Mouse Hoxc11 Gene: Genomic structure and expression pattern. Mech. Dev. 1998; 70: 133-145.
  • Wahba GM, Hostikka SL, Carpenter EM. The Paralogous Hox Genes Hoxa10 and Hoxd10 Interact to Pattern the Mouse Hindlimb Peripheral Nervous System and Skeleton. Dev. Biol. 2001; 231: 87-102
  • Fleming JN, Hostikka SL, Chen EY, Schwartz SM, Perkins JA. Plasmacytoid Dendritic Cells and Interferon Levels are Increased in Lymphatic Malformations. Otolaryngol Head Neck Surg. 2008; 139: 671-676.
  • Chen EY, Hostikka SL, Duke W, Oliaei S, Schwartz SM, Perkins JA. Similar histologic features and expression of lymphatic markers in microcystic and macrocystic lymphatic malformations. Otolaryngol Head Neck Surg, 2009; in press.
  • Hostikka SL, Gung J, Carpenter E. Targeted disruption of the Hoxc10 gene causes homeotic transformations in axial skeleton, an abnormal femoral ligament, and loss of lumbar motor neurons. Int. J. Biol. Sci. 2009; 5: 397-410.

Reviews

  • Hostikka SL, Tryggvason K. Comparison of the human basement membrane (type IV) collagen α1(IV) and α2(IV) chains and their genes. In: Progress in Basement Membrane Research. Renal and Related Aspects in Health and Disease. (M. - C. Gubler and M. Sternberg, eds.) John Libbey Eurotext Ltd., 1988; pp. 5-11.
  • Tryggvason K, Soininen R, Hostikka SL, Ganguly A, Huotari M, Prockop DJ. Structure of the human type IV collagen genes. Ann. N.Y. Acad. Sci. 1990; 508: 97-111.
  • Tryggvason K, Zhou J, Hostikka SL, Shows T. Molecular genetics of Alport syndrome. Kidney Int. 1993; 43: 38-44.
  • Tryggvason K, Zhou J, Hostikka SL. Alport syndrome and other inherited basement membrane disorders. In: Molecular and Cellular Aspects of Basement Membranes. (D. H. Rohrback and R. Timpl, eds.). Academic Press, 1993; pp. 421-437.
  • Tryggvason K, Zhou J, Hostikka SL, Sariola H. Type IV collagen in normal and diseased glomerular basement membrane. In: Advances in Nephrology, Vol 22. (J. P Grünfeld, J. F. Bach, H. Kreis and M. H. Maxwell, eds.). Mosby Year Book, 1993; pp. 1-14.

Patents

  • Tryggvason K, Hostikka SL. Method for determining the nucleotide sequence of a novel alpha5(IV) chain of human type IV collagen. U.S. Patent no. 5,114,840, May 19, 1992.
  • Tryggvason K, Hostikka SL, Höyhtyä M. Immunological methods for the detection of the human type IV collagen alpha5 chain. U.S. Patent no. 5,354,690, October 11, 1994. U.S. Patent no. 5,593,900, Jan. 14, 1997.
  • Tryggvason K, Hostikka SL, Zhou J. Method for determining the nucleotide sequence of the gene for the α5(IV) chain of human type IV collagen. Patent no. 6576418, June 10, 2003.
  
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