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Curriculum Vitae

Matthew Gill


Assistant Research Professor

Genetic analysis in the nematode Caenorhabditis elegans has identified conserved endocrine signaling pathways that act during development to regulate entry into a specialized diapause stage, the dauer larva, that allows the animal to survive adverse environmental conditions.  Many of the genes involved in dauer formation during development also act in the adult animal to determine lifespan.  My research combines the strength of C. elegans as a system for genetic analysis with chemical and biochemical approaches to study the endocrinology of development and lifespan determination, with a focus on lipophilic hormones and other small molecules.  Given the conservation of aging pathways between species, it is likely that this approach will identify new therapeutic targets for combating human aging and age-related disease.

Selected publications:

Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS. DAF-12-dependent rescue of dauer formation in C. elegans by 25S-cholestenoic acid. Aging Cell 2006 5(4):283-91
 
Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ. Lipophilic regulator of developmental switch in Caenorhabditis elegans. Aging Cell 2004 Dec;3(6):413-21
 
Gill MS. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 2006 5:23-30
 
Gill MS, Olsen A, Sampayo JN, Lithgow GJ. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med. 2003 35(6): 558-65.
 
Lithgow GJ, Gill MS. Physiology: Cost-free longevity in mice? Nature 2003 Jan 9;421(6919):125-6
 
S Melov, J Ravenscroft, S Malik, M Gill, D Walker, P Clayton, D Wallace, B Malfroy, S Doctrow, G Lithgow. Extension of lifespan with superoxide dismutase/catalase mimetics. Science 289: 1567-1569, 2000
 

Matthew Gill , Assistant Research Professor

List of Publications

 1. NKS Thalange, DA Price, MS Gill, AJ Whatmore, GM Addison & PE Clayton. Insulin-like growth factor binding protein-3 generation: an index of growth hormone insensitivity. Pediatric Research, 1996; 39: 849 - 855

2. NKS Thalange, PJ Foster, MS Gill, DA Price & PE Clayton. Model of normal prepubertal growth. Archives of Diseases in Childhood, 1996; 75: 427 – 431

3. V Tillman, DA Price, JK Wales, MS Kibirige, SM Shalet, J Buckler, GM Addison, MS Gill, AJ Whatmore & PE Clayton. Biochemical Tests in the diagnosis of childhood growth hormone deficiency. Journal of Clinical Endocrinology & Metabolism, 1997; 82: 531-535

4. MS Gill, AJ Whatmore, V Tillman, A White, GM Addison, DA Price & PE Clayton. Urinary IGF and IGF binding protein-3 in children with disordered growth. Clinical Endocrinology, 1997; 46: 483-492

5. PE Clayton, MS Gill, CM Hall, V Tillman, AJ Whatmore & DA Price. Serum leptin through childhood and adolescence. Clinical Endocrinology, 1997; 46: 727-733

6. MS Gill, AA Toogood, PA O’Neill, JE Adams, MO Thorner, SM Shalet & PE Clayton. Relationship between growth hormone (GH) status, serum leptin and body composition in healthy and GH deficient elderly subjects. Clinical Endocrinology, 1997,47, 161-167

7. MS Gill, AA Toogood, PA O’Neill, MO Thorner, SM Shalet & PE Clayton. Urinary growth hormone (GH), insulin-like growth factor (IGF)-I and IGF binding protein-3 measurements in the diagnosis of adult GH deficiency. Journal of Clinical Endocrinology & Metabolism, 1998, 83:2562-2565

8. MS Gill, AA Toogood, J Jones, PE Clayton & SM Shalet. Serum leptin response to the acute and chronic administration of Growth Hormone (GH) to elderly subjects with GH deficiency. Journal of Clinical Endocrinology & Metabolism, 1999, 84:1288-95

9. CM Hall, MS Gill, P Foster, L Pennells, V Tillmann, J Jones, DA Price & PE Clayton. Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence: their use in the assessment of disordered growth. Clinical Endocrinology, 1999, 50:611-618

10. MS Gill, CM Hall, V Tillmann & PE Clayton. Constitutional delay in growth and puberty is associated with hypoleptinaemia. Clinical Endocrinology, 1999, 50:721-726

11. MS Gill, NKS Thalange, PJ Foster, V Tillmann, DA Price, PJ Diggle & PE Clayton. Regular fluctuations in growth hormone (GH) release determine normal human growth. Growth hormone & IGF Research, 1999, 9:114-122

12. ES de A Barreto, MS Gill, MH Aguiar-Oliveira, CA Menezes, AHO Souza & PE Clayton. Serum Leptin and Body Composition in Children with Familial Growth Hormone (GH) Deficiency due to a Mutation in the Growth Hormone-Releasing Hormone (GHRH) Receptor. Clinical Endocrinology, 1999, 51: 559-564

13. MH Aguiar-Oliveira, MS Gill, ES de A Barretto, MRS Alcântara, F Miraki-Moud, CA Menezes, AHO Souza, CE Martinelli, FA Pereira, R Salvatori, MA Levine, SM Shalet, C Camacho-Hubner, PE Clayton. Effect of Severe Growth Hormone Deficiency due to a Mutation in the Growth Hormone Releasing Hormone Receptor on the Insulin-like Growth Factors (IGFs), IGF Binding Proteins and Ternary Complex Formation Throughout Life. Journal of Clinical Endocrinology & Metabolism, 1999, 84:4118-4126.

14. V Tillmann, MS Gill, NKS Thalange, G Birkinshaw, DA Price, WD Fraser, PE Clayton. Short-term changes in growth and urinary growth hormone, insulin-like growth factor-I and markers of bone turnover excretion in healthy prepubertal children. Growth Hormone & IGF Research, 2000, 10:28-36

15. S Melov, J Ravenscroft, S Malik, M Gill, D Walker, P Clayton, D Wallace, B Malfroy, S Doctrow, G Lithgow. Extension of lifespan with superoxide dismutase/catalase mimetics. Science 289: 1567-1569, 2000

16. MS Gill, V Tillmann, JD Veldhuis & PE Clayton. Patterns of GH output and their synchrony with shortterm height increments influence stature and growth performance in normal children. Journal of Clinical Endocrinology & Metabolism 86:5860-3, 2001.

17. Barreto-Filho JA, Alcantara MR, Salvatori R, Barreto MA, Sousa AC, Bastos V, Souza AH, Pereira RM, Clayton PE, Gill MS, Aguiar-Oliveira MH. Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J Clin Endocrinol Metab 2002 87(5):2018-23

18. Gleeson HK, Souza AH, Gill MS, Wieringa GE, Barretto ES, Barretto-Filho JA, Shalet SM, Aguiar-Oliveira MH, Clayton PE. Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan. Clin Endocrinol (Oxf) 2002 57(1):89-95

19. Zaman N, Hall CM, Gill MS, Jones J, Tillmann V, Westwood M, Whatmore AJ, Clayton PE. Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine. Clin Endocrinol (Oxf) 2003 Jan;58(1):78-85

20. Lithgow GJ, Gill MS. Physiology: Cost-free longevity in mice? Nature 2003 Jan 9;421(6919):125-6

21. Gill MS, Olsen A, Sampayo JN, Lithgow GJ. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med. 2003 35(6): 558-65.

22. Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ. Lipophilic regulator of developmental switch in Caenorhabditis elegans. Aging Cell 2004 Dec;3(6):413-21

23. Gill MS. Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans. Aging Cell 2006 5:23-30

24. Lithgow GJ, Gill MS, Olsen A, Sampayo JN. Pharmacological intervention in invertebrate aging. Age 27(3) 213-223 2005

25. Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS. DAF-12-dependent rescue of dauer formation in C. elegans by 25S-cholestenoic acid. Aging Cell 2006 5(4):283-91

26. Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol 2008 43(10):882-91.

  
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