Curriculum Vitae
Kunlin Jin

Associate Research Professor

Overall direction of my research program over the next 5 years

Aging is associated with a striking increase in the incidence of stroke and neurodegenerative diseases, which are major causes of disability among those aged 70 years and older in the United States.   Despite progress in understanding molecular mechanisms of neuronal cell death in these diseases, widely effective treatment remains elusive.  Studies have provided evidence that neurogenesis continues to occur in the brains of adult mammals, including humans. Our and other studies also show that the proliferation of neural stem/progenitor cells (NSCs) located in neurogenic regions is increased in response to stroke including in animals and humans, and that stroke-induced newborn cells can migrate into damaged brain regions, where they differentiate into mature neuronal cells and integrated into local neuronal circuits.  This raises the intriguing possibility that NSCs might be beneficial in the treatment of stroke, although the innate capacity for brain repair after stroke appears to be limited. The successful development of NSC recruitment therapy will depend on our ability to manage the proliferation, migration, differentiation and functional integration of recruited cells and the first step toward this goal is to investigate the molecular mechanisms governing NSC behaviors. Although stroke occurs mainly in the aged population, most animal studies investigating both stroke and neurogenesis are conducted on young-adult brains.  Hence, better understanding of how NSCs are regulated after stroke in the aged brain seems essential.   My laboratory attempts to dissect molecular mechanisms underlying regulation of stroke-induced neurogenesis by aging, which is currently supported by NIH R01 grant.

In addition, stroke survivors are often left with permanent neurological deficits, including paralysis or problems with thinking or speaking, due to permanent brain damage. Current treatment options for such deficits are limited and consist of mostly preventive measures. Accordingly, for many individuals who suffered strokes, the best hope is a lengthy program of rehabilitation, followed by a lifelong process of clinical support. There is thus a great need for new therapeutic developments.  Regeneration of damaged brain tissue in the infarction cavity after stroke may become possible through a tissue engineering approach. Scaffolds grafted in the cavity may not only provide the necessary biomechanical support for cells, and guide the gross shape and size of the regenerated tissue into forming three-dimensional tissues, but they also provide artificial stem cell niches necessary for stem cell growth. Additionally, scaffolds can serve as biochemical signals that influence cell adhesion, migration, proliferation, differentiation, and functions. However, whether regenerated brain tissue is able to rebuild complicated neural circuitries with the host brain remains questionable. To reach the goals of rebuilding damaged brain tissues, the tasks ahead are challenging: 1) whether damaged brain tissue after stroke can be regenerated by tissue engineering; 2) whether transplanted NSCs can differentiate functional neurons and integrate into the local neuronal circuitries; 3) whether regenerated brain tissue significantly contributes to the improvement of functional outcome after stroke. Our group continues to address these important questions, which eventually make it possible to regenerate brain tissue that is structurally functional and architecturally equivalent to the damaged tissue through tissue engineering and thereby develop powerful new therapies for stroke victims.

Research Fundings

• Primary Investigator: Kunlin Jin?Title: Aging and Neurogenesis?Agency: National Institute of Aging, NIH?Grant Number: RO1 #AG021980?Period:  05/01/2003-04/31/2008?$1240,000.00
  The goal of this project is to investigate the cellular and molecular mechanisms of neurogenesis in cerebral ischemia in aged brain.

• Primary Investigator: Kunlin Jin?Title: Functional contribution of neural stem cells in stroke
  Agency: National Institute of Neurological Disorders and Stroke (NINDS), NIH ?Grant Number: 1R01NS057186-01A2?Period:  07/01/2009-06/30/2011?$500,000.00??The goal of this project is to investigate the functional role of neural stem cells after stroke.??

Editor Board Member

• Guest Editor, CNS and Neurological Disorders-Drug Targets, 2007?
• Editorial Board Member. The Open Bioactive Compounds Journal, since 2008
• Associate Editor of International Journal of Physiology, Pathophysiology and Pharmacology, since 2009?
• Editorial Board Member of World Journal of Stem Cells, 2009-2013

Grant Ad hoc Reviewer

• Ad hoc Reviewer: NIH study section ZRG1 CB-G, 2008
• Ad hoc Reviewer: Association for International Cancer Research, 2008
• Ad hoc Reviewer: Alzheimer's Association Grants, 2008, 2009?
• Ad hoc Reviewer: NIH study section NCF, 2008, 2009
• Ad hoc Reviewer: New York State Department of Health and Empire State Stem Cell Board NYSTEM program, 2008, 2009?
• Ad hoc Reviewer: Neurological Foundation of New Zealand, 2008?
• Ad hoc Reviewer: American Heart Association (AHA), Spring 2009 Region 4 Brain 2
• Ad hoc Reviewer: NIH study section NOMD, 2009?
• Ad hoc Reviewer (mailing): NIH study section ZRG1 BDA, 2009
• Ad hoc Reviewer: NIH study section ZRG1 MDCN, 2009
• Ad hoc Reviewer: NIH study section BDCN, 2009

Journal: Ad hoc reviewer

• Journal of Cerebral Blood Flow and Metabolism?
• Journal of Neurochemistry
• Aging Cell
• Brain Research
• Stroke?
• Neuroscience
• Journal of Neuroscience Research?
• Experimental Brain Research?
• Acta Neuropathologica?
• Neurochemistry International?
• Neurobiology of Disease
• Stem Cells?
• Journal of Experimental Medicine
• Behavioural Brain Research?
• Neuroscience letters
• Molecular and Cellular Neuroscience
• Journal of Alzheimer's Disease?
• Synapse?
• Journal of Cellular and Molecular Medicine
• Gene Therapy?
• Annals of Neurology
• Neurobiology of Aging

 
Kunlin Jin, Associate Research Professor

List of Publications

• ZhuGe Q, Zhong M, Zheng W, Yang GY, Mao MO, Xie L, Chen G, Chen Y, Lawton MT, Young WL, Greenberg DA and Jin K. Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain, 2009, Oct.
   
• 1   Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, Gorostiza O, Wang X, Greenberg DA. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab. 2009 Oct. 14
   
• Wang X, Mao X, Xie L, Greenberg DA, Jin K. Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. J Cereb Blood Flow Metab. 2009 Oct;29(10):1644-54.
   
• Tang H, Wang Y, Xie L, Mao XO, Won SJ, Galvan V, Jin K. Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after ischemia. Neurobiology of Aging, 2009 Feb;30(2):299-308.
   
• Wang W, Jin K, Mao XO, Close N, Greenberg DA, Xiong ZG. Electrophysiological properties of mouse cortical neuron progenitors differentiated in vitro and in vivo. Int J Clin Exp Med. 2008;1(2):145-53.
   
• Lai B, Mao XO, Xie L, Jin K, and Greenberg DA. Electrophysiological neurodifferentiation of subventricular zone-derived precursor cells following stroke. Neurosci Lett. 2008 Sep 19;442(3):305-8.
   
• Yao Y, Wang X, Jin K, Zhu J, Wang Y, Xiong S, Mao Y, Zhou L. B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells. J Neurooncol. 2008 Sep;89(2):121-9
   
• Peng J, Xie L, Jin K, Greenberg DA, Andersen JK. Fibroblast growth factor 2 enhances striatal and nigral neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neuroscience. 2008 May 15;153(3):664-70.
   
• Zhao B, Zhong M, Jin K. Neurogenesis and neurodegenerative diseases in human. Panminerva Med. 2008 Mar;50(1):55-64.
   
• Khan AA, Mao X, Banwait S, Dermardirossian CM, Bokoch GM, Jin K, Greenberg DA. Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J. 2008 Jun;22(6):1737-47.
   
• Shen F, Xie L, Mao XO, Zhou YQ, Zhan, R, Greenberg, DA and Jin K.  Neurogenesis after Primary Intracerebral Hemorrhage in Adult Human Brain. J Cereb Blood Flow Metab. 2008 Aug;28(8):1460-8
   
• Lai B, Mao XO, Greenberg, DA and Jin K. Endothelium-induced Proliferation and Electrophysiological Differentiation of Human Embryonic Stem Cell-derived Neural Cells in Vitro. Stem cell development. 2008 Jun;17(3):565-72
   
• Jin K, Mao XO, Xie L, Khan AA, Greenberg DA. Neuroglobin protects against nitric oxide toxicity. Neurosci Lett. 2008 Jan 10;430(2):135-7.
   
• Khan AA, Mao XO, Banwait S, Jin K, Greenberg DA. Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19114-9
   
• Wang Y, Jin K, Greenberg DA. Neurogenesis associated with endothelin-induced cortical infarction in the mouse. Brain Res. 2007 Sep 5;1167:118-22.
   
• Galvan, V and Jin K. Neurogenesis in the aging brain. Clinical Interventions in Aging. 2007;2(4):605-10.
   
• Jin K and Galvan, V., Endogenous Neural Stem Cells in the Adult Brain. Journal of Neuroimmune Pharmacology. 2007. Sep;2(3):236-42.
   
• Tang H, Wang Y, Xie L, Mao XO, Won SJ, Galvan V, Jin K. Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after ischemia. Neurobiology of Aging, 2007, Feb;30(2):299-308
   
• Khan AA, Sun Y, Jin K, Mao XO, Chen S, Ellerby LM, Greenberg DA. A neuroglobin-overexpressing transgenic mouse.  Gene. 2007 Aug 15;398(1-2):172-6
   
• Wang Y, Jin K, Mao XO, Xie L, Banwait S, Martin H, Greenberg D. VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration. J Neurosci Res. 2007 Mar;85(4):740-7.
   
• Jin K and Galvan, V., Endogenous Neural Stem Cells in the Adult Brain. Journal of Neuroimmune Pharmacology. 2007 Sep;2(3):236-42
   
• Greenberg DA and Jin K. Regenerating the brain. Int Rev Neurobiol. 2007;77:1-29
   
• Wang Y, Mao XO, Xie L, Banwait S, Martin H, Greenberg D, Jin K. VEGF overexpression delays neurodegeneration and prolongs survival in ALS mice. J Neuroscience. 2007 Jan 10;27(2):304-7.
   
• Mao Y, Zhou LF, Zhu W, Yang GY, Xie L, Mao OU, Jin K. Proliferative Status of Neural Stem/Progenitor Cells Correlateswith Malignancy Grade of Human Astrocytomas. Frontier in Bioscience. 2007, Jan, 12;2252-2259
   
• Khan AA, Wang Y, Sun Y, Mao XO, Xie L, Miles E, Graboski J, Chen S, Ellerby LM, Jin K, Greenberg DA. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17944-8.
   
• Won SJ, Xie L, Kim SH, Tang H, Wang Y, Mao X, Banwait S, Jin K. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res. 2006. Dec 6;1123(1):237-44.;
   
• Wang Y, Galvan V, Gorostiza O, Ataie M, Jin K, Greenberg DA. Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Res. 2006 Oct 18;1115(1):186-93.
   
• Jin K, Wang X, Xie L, Mao XO, Zhu W, Wang Y, Shen J, Mao Y, Banwait S, Greenberg DA. Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202.
   
• Greenberg DA, Jin K. Turning neurogenesis up a Notch. Nat Med. 2006 Aug;12(8):884-5.
   
• Greenberg DA and Jin K. Growth factors and stroke. NeuroRx. 2006 Oct;3(4):458-65
   
• Galvan G, Greenberg DA and Jin K. The role of vascular endothelial growth factor in neurogenesis in adult brain. MRMC, 2006, June; 6(6); 667-669
   
• Greenberg DA and Jin K. Neurodegeration and neurogenesis: focus on Alzheimer’s disease. Current Alzheimer Research, 2006 Feb;3(1):25-8.
   
• Kim SH, Won SJ, Mao XO, Ledent C, Jin K, Greenberg DA. Role for Neuronal Nitric Oxide Synthase in Cannabinoid-induced Neurogenesis. J Pharmacol Exp Ther. 2006 Oct;319(1):150-4.
   
• Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.  Proc Natl Acad Sci U S A. 2006 May 2;103(18):7130-5.
   
• Jin K, Xie L, Mao XO, Greenberg DA. Alzheimer's disease drugs promote neurogenesis. Brain Res. 2006 Apr 26;1085(1):183-8.
   
• Won SJ, Kim SH, Xie L, Wang Y, Mao XO, Jin K, Greenberg DA. Reelin-deficient mice show impaired neurogenesis and increased stroke size  Exp Neurol. 2006 Mar;198(1):250-9.
   
• Greenberg DA, Jin K.  From angiogenesis to neurogenesis. Nature 2005 Dec 15;438(7070):954-9.
   
• Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration. Dev Biol. 2006 Jan 15;289(2):329-35.
   
• Jin K, Lafevre-Bernt M, Sun Y, Chen S, Gafni J, Crippen D, Logvinova A, Ross CA, Greenberg DA, Ellerby LM. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18189-94
   
• Jin K, Mao XO, Greenberg DA. Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling. J Neurobiol. 2006 Feb 15;66(3):236-42
   
• Kim SH, Won SJ, Mao XO, Jin K, Greenberg DA. Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. Mol Pharmacol. 2006 Mar;69(3):691-6
   
• Jin K, Mao XO, Del Rio Guerra G, Jin L, Greenberg DA. Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase.  J Neurosci Res. 2005 Aug 15;81(4):497-505.
   
• Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA. Neuronal nitric oxide synthase and ischemia-induced neurogenesis. J Cereb Blood Flow Metab. 2005 Apr;25(4):485-92.
   
• Jin K, Sun Y, Xie L, Mao XO, Childs J, Peel A, Logvinova A, Banwait S, Greenberg DA. Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol Dis. 2005 Mar;18(2):366-74.
   
• Sun Y, Jin K, Mao XO, Xie L, Peel A, Childs JT, Logvinova A, Wang X, Greenberg DA. Effect of aging on neuroglobin expression in rodent brain. Neurobiol Aging. 2005 Feb;26(2):275-8.
   
• Kim SH, Won SJ, Mao XO, Jin K, Greenberg DA. Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury. J Pharmacol Exp Ther. 2005 Apr;313(1):88-94.
   
• Greenberg DA and Jin K.  Neural gene therapy: Sensational finding. Gene Therapy. 2005 Aug;12(15):1161-2.
   
• Greenberg DA and Jin K. VEGF and ALS: the luckiest growth factor? Trands in molecular Medicine. 2004 Jan; 10(1): 1-3
   
• Jin K, Minami M, Xie L, Sun Y, Mao XO, Wang Y, Simon PR and Greenberg DA. Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain. Aging Cell. 2004 Dec; 3(6):373-7.
   
• Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA. Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J Cereb Blood Flow Metab. 2004 Oct;24(10):1146-52
   
• Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, Greenberg DA. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.?Proc Natl Acad Sci U S A. 2004 Sep 7; 101(36):13363-7.
   
• Greenberg DA, Jin K.  Experiencing VEGF. Nat Genet. 2004 Aug;36(8):792-3.
   
• Jin K, Xie L, Kim SH, Parmentier-Batteur S, Sun Y, Mao XO, Childs J, Greenberg DA. Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice.?Mol Pharmacol. 2004 Aug; 66(2):204-8.
   
• Jin K, Sun Y, Xie L, Childs J, Mao XO, Greenberg DA. Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 2004 Apr; 24(4):399-408.
   
• Jin K, Mao XO, Cottrell B, Schilling B, Xie L, Row RH, Sun Y, Peel A, Childs J, Gendeh G, Gibson BW, Greenberg DA. Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis. FASEB J. 2004 Feb; 18(2):287-99.
   
• Jin K, Mao XO, Greenberg DA. Proteomic analysis of neuronal hypoxia in vitro. Neurochemical Research 2004 June, 29 (6): 1123–1128
   
• Jin K, Peel A, Mao XO, Xie L, Batteur S, Greenberg DA. Increased hippocampal neurogenesis in Alzheimer’s disease. Proc Natl Acad Sci U S A.  2004 Jan 6;101(1):343-7.
   
• Jin K, Mao XO, Batteur S Sun Y, and Greenberg DA. Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expression Experimental Neurology 2003 Nov;184(1):78-89
   
• Jin K, Sun Y, Xie L, Peel A, Mao XO, Batteur S, Greenberg DA.  Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Molecular and Cellular Neuroscience 2003 Sep; 24(1):171-89
   
• Zhu Y, Sun Y, Xie L, Jin K, Sheibani N, Greenberg DA. Hypoxic Induction of Endoglin via Mitogen-Activated Protein Kinases in Mouse Brain Microvascular Endothelial Cells. Stroke. 2003 Aug 28
   
• Jin K, Sun Y, Xie L, Batteur S, Mao XO, Smelick C, Logvinova A, Greenberg DA. Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. Aging Cell. 2003 Jun; 2(3):175-83.
   
• Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.?J Clin Invest. 2003 Jun; 111(12):1843-51.
   
• Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem. 2003 May; 85(3):670-9.
   
• Sun Y, Jin K, Peel A, Mao XO, Xie L and Greenberg DA. Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci U S A.  2003, March 28. 100 (6): 3497–3500.
   
• Jin K, Xie L, Childs J, Sun Y, Mao XO, Logvinova A, Greenberg DA. Cerebral neurogenesis is induced by intranasal administration of growth factors. Ann Neurol. 2003 Mar; 53(3):405-9.
   
• Sun Y, Jin K, Clark KR, Peel A, Mao XO, Chang Q, Simon RP, Greenberg DA. Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia. Gene Ther. 2003 Jan; 10(2):115-22.
   
• Zhu Y, Jin K, Mao XO and Greenberg DA. Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J. 2003 Feb;17(2):186-93
   
• Jin K and Greenberg DA. Tales of transdifferentiation. Experimental Neurology 2003; 183: 255–257.
   
• Parmentier-Batteur S, Jin K, Mao XO, Xie L, Greenberg DA. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J  Neurosci.  2002 Nov 15; 22(22):9771-5.
   
• Jin K, Mao XO, Eshoo M, del Rio G, Rao R, D Chen, Simon RP and Greenberg DA. cDNA microarray analysis of changes in gene expression induced by neuronal hypoxia in vitro. Neurochemical Research 2002 Oct, 27 (10): 1101–1108
   
• Zhu Y, Sun Y, Jin K, and Greenberg DA. Hemin induces neuroglobin expression in neural cells Blood. 2002 Oct; 100(7): 2494-2498.
   
• Parmentier-Batteur S, Jin K, Xie L, Mao XO, Greenberg DA. DNA microarray analysis of cannabinoid signaling in mouse brain in vivo. Mol Pharmacol 2002 Oct; 62(4):828-35.
   
• Jin K, Mao XO, Sun Y, Xie L, Jin L, Nishi E, Klagsbrun M, and Greenberg DA.  Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo. J Neurosci. 2002 Jul, 22: 5365-5373.
   
• Jin K, Zhu Y, Sun Y, Mao X, Xie L, and Greenberg DA. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A.  2002, Aug 14. 99(18)11946-11950.
   
• Jin K, Mao X, Sun Y, Xie L, Yonghua Zhu and Greenberg DA. Stem cell factor stimulates neurogenesis in vitro and in vivo. J Clin Invest. 2002 Aug; 110(3):311-9.
   
• Jin K, Nagayama T, Mao X, Kawaguchi K, Hickey RW, Greenberg DA, Simon RP and Graham SH.  Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. J Neurochem. 2002 81:25-35.
   
• Zhu Y, Mao X, Jin K, and Greenberg DA. Expression of poly(C)-binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons. Neuroscience. 2002 Mar 10; 110(2):191-198.
   
• Jin K, Mao X, Yonghua Zhu and Greenberg DA. MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem. 2002 80:119-125.
   
• del Rio G, Bartley TF, del-Rio H, Rao R, Jin K, Greenberg DA, Eshoo M and Bredesen DE. Mining DNA microarray data using a novel approach based on graph theory. FEBS letters.  2001 Dec 7; 509(2):230-234.
   
• Jin K, Graham SH, Nagayama T, Goldsmith PC, Greenberg DA, Zhou A, Simon RP. Altered Expression of the Neuropeptide-Processing Enzyme Carboxypeptidase E in the Rat Brain After Global Ischemia. J Cereb Blood Flow Metab. 2001 Dec;21(12):1422-1429
   
• Jin K, Graham SH, Mao XO, Nagayama T, Simon RP and Greenberg DA. Fas (CD95) May Mediate Delayed Cell Death in Hippocampal CA1 Sector after Global Cerebral Ischemia.  J Cereb Blood Flow Metab. 2001 Dec;21(12):1411-1421
   
• Sun Y, Jin K, Mao X, Zhu Y and Greenberg DA. Neuroglobin is upregulated by and protects neurons from hypoxic-ischemic injury. Proc Natl Acad Sci U S A. 2001 Dec 11; 98(26):15306-15311.
   
• Jin K, Mao XO, Batteur SP, McEachron E, Leahy A, and Greenberg DA. Caspase-3 and the Regulation of Hypoxic Neuronal Death by Vascular Endothelial Growth Factor. Neuroscience. 2001 Dec 10; 108(2):351-358.
   
• Clark RSB, Chen M, Kochanek PM, Watkins SC, Jin K, Draviam R, Nathaniel PD, Pinto R, Marion DW, Graham SH. Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase. J Neurotrauma 2001 Jul;18(7):675-89
   
• Shimizu S, Nagayama T, Jin K, Zhu L, Loeffert JE, Watkins SC, Graham SH and Simon RP. bcl-2 Antisense Treatment Prevents Induction of Tolerance to Focal Ischemia in the Rat Brain.?J Cereb Blood Flow Metab. 2001 Mar; 21(3):233-243.
   
• Jin K, Granham SH, Mao XO, He XJ, Nagayama T, Simon RP and Greenberg DA. Bax??, a Novel Bax Splice Variant Lacking an ART Domain, from Rat Ischemic Brain Promotes Neuronal Cell Death. J Neurochem. 2001 Jun; 77(6): 1508-1519.
   
• Johnson MB, Jin K, Minami M, Chen D, Simon RP. Global Ischemia Induced Expression of ASIC2 in the Rat Brain. J Cereb Blood Flow Metab. 2001, Jun; 21(6):734-40.
   
• Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP and Greenberg DA. Neurogenesis in Dentate Subgranular Zone and Rostral Subventricular Zone after Focal Cerebral Ischemia in the Rat. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4710-4715.
   
• Jin K, Mao XO, Eshoo MW, Nagayama T, Minami M, Simon RP and Greenberg DA. Microarray Analysis of Hippocampal Gene Expression in Global Cerebral Ischemia. Ann Neurol. 2001 Jul, 50 (1): 93-103.
   
• Jin K, Mao XO, Simon RP, Greenberg DA. Cyclic AMP Response Element Binding Protein (CREB) and CREB Binding Protein (CBP) in Global Cerebral Ischemia. J Mol Neurosci. 2001 16:49-56
   
• He X, JIN K, Clark R, Graham SH. Cloning of Rat bcl-xL cDNA and Production of Large /amount of Highly Purified Recombinant bcl-xL/AAV. Chinese J of Biochem & Mol Biol. 2001; 17 (4):
   
• Jin K, Mao XO, Greenberg DA. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10242-10247
   
• Jin K, Mao XO, and Greenberg DA. Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal. J Mol Neurosci. 2000 Jun;14(3):197-203.
   
• Jin K, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA. Induction of vascular endothelial growth factor and hypoxia-inducible factor-1a by global ischemia in rat brain. Neuroscience. 2000 99 (3):577-585
   
• Jin K, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA. Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3'-kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience. 2000 Oct 11; 100(4):713-717.
   
• Jin K, Mao XO, Goldsmith PC, Greenberg DA. CB1 cannabinoid receptor induction in experimental stroke.   Ann Neurol. 2000 Aug; 48(2):257-61.
   
• Hickey RW, Zhu RL, Alexander HL, Jin K, Stetler RA, Chen J, Kochanek PM, Graham SH. 10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat. Brain Res Mol Brain Res 2000 Jun 23;79(1-2):169-173
   
• Clark RS, Kochanek PM, Watkins SC, Chen M, Dixon CE, Seidberg NA, Melick J, Loeffert JE, Nathaniel PD, Jin K, Graham SH. Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem. 2000 Feb;74(2):740-53
   
• Jin K, Li W, Nagayama T, He X, Sinor AD, Chang J, Mao X, Graham SH, Simon RP, Greenberg DA. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. J Neurosci Res. 2000 Mar;59(6):767-774
   
• Minami M, Jin K, Li W, Nagayama T, Henshall DC, Simon RP. Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat. Neurosci Lett. 2000 Feb 4;279(3):193-5
   
• Li W, Jin K, Nagayama T, He X, Chang J, Minami M, Greenberg DA, Graham SH, Simon RP: Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia. Neuroscience. 2000, 96: 161-168.
   
• Timpe LC, Jin K, Puelles L, Rubenstein JL. Cyclic nucleotide-gated cation channel expression in embryonic chick brain. Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):175-8
   
• Jin K, Chen J, Nagayama T, Stetler AR, Simon RP, and Graham SH. Molecular cloning of a cell cycle-regulation gene cyclin H from ischemic rat brain: expression in neurons after global cerebral ischemia.  J Neurochem. 1999, 73, 1598-1680.
   
• Nagayama T, Sinor, AM, Chen J, Graham SH, Jin K, and Greenberg DA.  Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci. 1999 Apr 15;19(8):2987-95
   
• Jin K, Chen J, Nakayama M, Chen M, Graham SH and Simon RP. In situ detection of neuronal DNA strand breaks using Klenow fragment of DNA polymerase I reveals different mechanisms of neuronal death after global ischemia. J Neurochem.  1999 72(3): 1204-1214
   
• Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, and Simon RP.  Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.  J Neurosci. 1998 Jul 1;18(13):4914-4928
   
• Chen J, Uchimura K, Stetler RA, Zhu RL, Nakayama M, Jin K, Graham SH, Simon RP. Transient global ischemia triggers expression of the DNA damage-inducible gene GADD45 in the rat brain. J Cereb Blood Flow Metab. 1998 Jun;18(6):646-657
   
• Chen J, Jin K, Chen M, Pei W, Kawaguchi K and Greensburg DA. Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in neuronal cell death. J Neurochem.  1997, 69:232-245.
   
• Zhu L, Graham SH, Jin K, Stetler RA, Simon RP and Chen J.  Kainate induces the expression of the DNA damage-inducible gene, GADD45, in the rat brain. Neuroscience. 1997; 81:707-720.
   
• White MJ, Chen J, Zhu J, Irvin S, Sinor A, DiCaprio MJ, Jin K and Greensburg DA.    A Bcl-2 antisense oligonucleotide increased AMPA toxicity in cultured cortical neurons. Ann Neurol. 1997: 42(4), 580-587
   
• Jin K, Chen J, Kawaguchi K, Zhu RL, Stetler R.A., Simon RP and Graham SH. Focal ischemia induces expression of the DNA damage-inducible gene GADD45 in the rat brain.  Neuroreport.  1996; 7:1797-1802.
   
• Graham S.H, Chen J, Stetler R.A., Zhu R.L, Jin K, and Simon R. P.  Expression of the proto-oncogene bcl-2 is increased in the rat brain following kainate-induced seizures Restorative Neurology and Neuroscience.  1996; 9:243-250.
   
• Chen J, Zhu RL, Nakayama M, Kawaguchi K, Jin K, Stetler RA, Simon RP and Graham SH. Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia. J Neurochem.   1996; 67. 64-67
   
• Chen J, Zhu RL, Jin K, Stetler A, Simon RP and Graham SH. Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia J Cereb Blood Flow Metab.  1996;17: 243-250.
   
• Jin K, Wang SW and Lu DP. Amplification of human sex-determining gene for prenatal sex determination Beijing Med Univer J.  1994; 26:451-454
   
• Jin K, Wang SW, Lu DP, Liu FX, Fu XW, Zhang Q and Chen ZW. A study of relation between ZFY gene and abnormal sexual character diseases. Beijing Med Univer J.   1993; 25:406
   
• Liu XR, Wang SW and Jin K. Analysis of HLA-DQA gene with PCR-SSCP. J Chinese Epidemiology.   1992; 3:313-316.
   
• Wang ST, Liu XR, Jin K, Wang LL, Yan C, Lu DP. Analysis of DR-DQ1 in Chinese IDDM by PCR and biotinylated oligonucleotide probes. Constitutional Med. 1992; 55, suppl., 76-79
   
• Jin K, Wu YQ, Wang SW and Sun NG.  The labeling effect of ratio Bio-11-dUTP/ dTTP on HBV DNA probe. J Chinese Epidemiology. 1992; 13:280
   
• Jin K.   Gene therapy and ethics.  J Med and Philosophy. 1992; 2: 23-25
   
• Liu XR, Jin K, Wang SW and Liu DP.  Analysis of HLA-DQa gene types by amplified DNA fragments probed with biotinylated oligonucleotides   Chinese Biochemical J. 1991; 6:538-542.
   
• Jin K, Liu XR, Wang SW, Liu DP.  Chromosome in situ hybridization using biotinylated DNA probes. Chinese Eugenic J. 1991; 2:21-24.
   
• Jin K, Wang SW and Lu DP.  A method of rapid fetal sex determination by polymerase chain reaction. J Beijing Med Univ.  1991; 23:179-180
   
• Liu YC, Gao FY, Jin K and Wang ST. Rapid sex determination of boiled dead tissues by PCR method. Chinese J Forensic Med. 1990; 5:160-161                       
   
• Jin K, Wang SW and Liu DP.  Use of biotinylated DNA probes for rapid prenatal sex determination.  Beijing Med Univ J.  1990; 22:369-371.
   
• Jin K, Zhang P, Wang SW, Gou NL and Lu DP.  HLA DNA typing of bone marrow transplantation with PCR and ASO probes. J Chinese Hematol. 1990, 11: 646-648
   
• Jin K, Wang ST, Cheng LL and Zhang GR. The effect of deferoxamin on the proliferation of HL-60 cells. Beijing Med Univ J.   1990, 22:37-41.
   
• Jin K, Lu DP, and Wang SW. Gene therapy: concept, current and prospects.  J Clinical Hematology.  1989; 4: 161-163

BOOKS and chapters:

• Jin K (Ed): Neurogenesis and CNS diseases, Research Signpost. 2010, in press.
   
• Jin K (Ed) and GY (Co-Ed). Experimental Stroke. Bentham Science Publishers. Dec. 16, 2008 (ISBN: 978-1-60805-001-7)
   
• Jin K (Ed). How to write and publish a scientific paper in SCI journals. Science Press. Beijing. 2008
   
• Jin K. Reelin and Stroke. In Fatemi SH, Reelin Glycoprotein: Structure, Biology and Roles in Health Disease. Springer 2008.
   
• Greenberg DA, Jin K, Galvan V, Bredesen DE: Neurogenesis and Alzheimer’s disease. In Sun M-K (ed), Research Progress in Alzheimer’s Disease and Dementia, Vol. 1. New York, Nova Science Publishers, 2007:177-190
   
• Jin K, Chen J, Simon RP.  Intrinsic and extrinsic pathways of caspase activation in cerebral ischemia.  In Pharmacology of Cerebral Ischemia 2000, J. Krieglstein S. Klumpp (Eds.) Medpharm Sci Pub, Stuttgart, pp.145-150
   
• Zhu P, Liu XH, Zhang ML, Zhang YL, Jin K, Zhen H, Song WY, et al.   PCR: A laboratory Manual   Chinese Scientific Publish, Beijing.  1991.
   
• Wang SW, Jin K, Liu XR, Zhang P, and Zhang LH. Gene Diagnosis Technique--A laboratory Manual of Non-radioactive Operation. Beijing Medical University and Chinese Academic University Publish, Beijing. 1993