Nathan Shock Center
The Institute The Institute The Science Get Involved Healthy aging

Nathan Shock Center of Excellence.

The National Institute on Aging (NIA) has funded five Nathan Shock Centers to create the strongest possible environment for basic aging research. Named after Nathan Wetherell Shock PhD, the first scientific director of the NIA, the Shock grants enhance the ability of institutions to utilize state-of-the-art research resources. Research at the Centers is expected to lead to breakthroughs in understanding the aging process and the diseases that affect older people.

The Buck Institute's Shock Center includes the:

Genomics Core : Produces DNA microarrays through high throughput automation, and involves robotic production and spotting of either cDNA or oligonucleotides onto glass slides.

Chemistry/Proteomics Core: Targets pathological processes associated with protein structures in aging systems. The emphasis is on using mass spectrometry-based technologies and chemical methods to identify posttranslational protein modifications which appear to play important roles in aging and age-related diseases.

Cellular Imaging and Morphology Core: Provides centralized microanatomical and imaging resources including basic histology, immunohistochemstry and immunofluorescence and confocal microscopy

Animal/Transgenics Core: Produces transgenic and gene-knockout mince, breeding of genetically modified mice, genotyping, anatomical characterization of transgene expression, cryopreservation of transgenic mouse lines and periodic analysis of mouse lines to insure stability.

Research Development Core: Promotes the Center's unifying objective by fostering and developing investigators and projects in aging research.

Administrative/Program Enrichment Core: Provides administrative support specifically for the Shock Center and insures Shock Center growth.

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