The Science The Institute The Science Get Involved Healthy aging

2008 

Klionsky, D.J., Abeliovich, H., Agostinis, P., Agrawal, D.K., Aliev, G., Askew, D.S., Baba, M., Baehrecke, E.H., Bahr, B.A., Ballabio, A., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008;4:151-175.

Banwait, S., Galvan, V., Zhang, J., Gorostiza, O.F., Ataie, M., Huang, W., Crippen, D., Koo, E. and Bredesen, D.E. C-Terminal Cleavage of the Amyloid-β Protein Precursor at Asp664: A Switch Associated with Alzheimer’s Disease. J Alzheimers Dis in press

Nguyen, T.V., Galvan, V., Huang, W., Banwait, S., Tang, H., Zhang, J. and Bredesen, D.E. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem 2008;104:1065-1080.

2007

Young, J.E., Gouw, L., Propp, S., Sopher, B.L., Taylor, J., Lin, A., Hermel, E., Logvinova, A., Chen, S.F., Chen, S., Bredesen, D.E., Truant, R., Ptacek, L.J., La Spada, A.R. and Ellerby, L.M. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. J Biol Chem 2007;282:30150-30160.

Stoka V., Turk, V. and Bredesen, D.E. Differential Regulation of Smac/DIABLO and Hsp-70 During Brain Maturation. NeuroMolecular Medicine 2007;9:255-563.

Nguyen, T.V., Galvan, V., Huang, W., Banwait, S., Tang, H., Zhang, J. and Bredesen, D.E. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem 2008;104:1065-1080.

Madden, D.T., Egger, L. and Bredesen, D.E. A Calpain-Like Protease Inhibits Autophagic Cell Death. Autophagy 2007;3: 519-522.

Levy, R.M., Bredesen, D.E. and Rosenblum, M.L. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985. J Neurosurg 2007;107:1253-1273; discussion 1251.

Kurakin, A., Swistowski, A., Wu, S.C. and Bredesen, D.E. The PDZ domain as a complex adaptive system. PLoS ONE 2007;2:e953.

Kurakin, A. and Bredesen, D.E. An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain. J Mol Recognit 2007;20:39-50.

Galvan V and Bredesen DE. Neurogenesis in the adult brain: implications for Alzheimer’s disease. CNS and Neurological disorders: Drug Targets 2007;6:303-310.

Galvan, V., Banwait, S., Spilman, P., Gorostiza, O.F., Peel, A., Ataie, M., Crippen, D., Huang, W., Sidhu, G., Ichijo, H. and Bredesen, D.E. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis 2007;28:65-75.

Egger, L., Madden, D.T., Rheme, C., Rao, R.V. and Bredesen, D.E. Endoplasmic reticulum stress-induced cell death mediated by the proteasome. Cell Death Differ 2007;14:1172-1180.

Del Rio, G., Kane, D.J., Ball, K.D. and Bredesen, D.E. A novel motif identified in dependence receptors. PLoS ONE 2007;2:e463.

Cusack, M.P., Thibert, B., Bredesen, D.E. and Del Rio, G. Efficient identification of critical residues based only on protein structure by network analysis. PLoS ONE 2007;2:e421.

Bredesen, D.E. and Rabizadeh, S. APP-based neuroprotective strategies. Curr Alzheimer Res 2007;4:541-543.

Bredesen DE. Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke 2007 Feb; 38(2 Suppl):652-60.

2006

Shaked G.M., Kummer, M.P., Lu, D.C., Galvan, V., Bredesen, D.E. and Koo, E.H. Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). Faseb J 2006;20:1254-1256.

Saganich M.J., Schroeder, B.E., Galvan, V., Bredesen, D.E., Koo, E.H. and Heinemann, S.F. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci 2006;26:13428-13436.

Bredesen DE, Rao RV, Mehlen P. Cell death in the nervous system. Nature 2006; 443:796-802.

Stoka V, Turk V, Bredesen DE. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett. 2006 Jun 26; 580(15):3739-45. Epub 2006 Jun 9. (PubMed)

Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA and Bredesen DE. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A 2006; 103:7130-7135.

Rao RV, Niazi K, Mollahan P, Mao X, Crippen D, Poksay KS, Chen S and Bredesen DE. Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23. Cell Death Differ 2006; 13:415-425.

Peel AL, Sorscher N, Kim JY, and Bredesen DE. Protein Phosphorylation in Huntington's Disease. DNA & Cell Biology, in revision.

2005

Bredesen DE, Mehlen P, and Rabizadeh S. Receptors that mediate cellular dependence. Cell Death Differ 2005; 12:1031-1043.

Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, and Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol 2005; 58:277-289.

Stoka, V, Chen, SF, Turk, V and Bredesen, DE. Developmental shift in the apostat: Comparison of neurones and astrocytes. FEBS Lett 2005, 579:6147-6150.

Thibert B, Bredesen DE and Del Rio G. Improved prediction of critical residues for protein function based on network and phylogenetic analyses. BMC Bioinformatics 2005a; 6:213.

Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY and Williams TF. Science fact and the sens agenda. EMBO Rep 2005; 6:1006-1008.

2004

Bredesen DE, Mehlen P, and Rabizadeh S. Apoptosis and dependence receptors: A molecular basis for cellular addiction. Physiol Rev 2004; 84:411-430.

Bredesen DE. Rebuttal to Austad: 'Is aging programmed? Aging Cell 2004; 3:261-262.

Bredesen DE. The non-existent aging program: How does it work? Aging Cell 2004; 3:255-259.

Bredesen DE. Toward a mechanistic taxonomy of cell death programs. J Alzheimers Dis 2004; 6:S3-6.

Castro-Obregon S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, and Bredesen DE. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, erk2, and nur77. J Biol Chem 2004; 279:17543-17553.

Galvan V, Kurakin AV, and Bredesen DE. Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. FEBS Lett 2004; 558:57-62.

Galvan V, Saganich M, Schroeder B, Gorostiza OF, Logvinova A, Banwait S, Jin K, Greenberg DA, Mucke L, Heinemann S, Koo EH, and Bredesen DE. (2004) in Society for Neuroscience, ScholarOne, Inc., San Diego, CA

Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M, and Nishimoto I. Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75ntr/PLAIDD. J Neurochem 2004; 90:549-558.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, and Ellerby LM. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ 2004; 11:424-438.

Jin K, Galvan V, Xie L, Mao XO, Gorostiza OF, Bredesen DE, and Greenberg DA. Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A 2004; 101:13363-13367.

Kurakin A, Wu S, and Bredesen DE. Target-assisted iterative screening of phage surface display cDNA libraries. Methods Mol Biol 2004; 264:47-60.

Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, and Mehlen P. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 2004; 431:80-84.

Mehlen P, and Bredesen DE. The dependence receptor hypothesis. Apoptosis 2004; 9:37-49.

Peel AL, Sorscher N, Kim JY, Galvan V, Chen S, and Bredesen DE. Tau phosphorylation in Alzheimer's disease: potential involvement of an app-map kinase complex. Neuromolec Med 2004; 5:205-18.

Rao RV, and Bredesen DE. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 2004; 16:653-62.

Rao RV, Poksay KS, Castro-Obregon S, Schilling B, Row RH, del Rio G, Gibson BW, Ellerby HM, and Bredesen DE. Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem 2004; 279:177-187.

Rao RV, Ellerby HM, and Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 2004; 11:372-380.

Schroeder B, Saganich M, Galvan V, Long JM, Bredesen DE, Heinemann S, and Koo EH. (2004) in Society for Neuroscience, ScholarOne, Inc., San Diego, CA

Sperandio S, Poksay K, De Belle I, Lafuente MJ, Liu B, Nasir J, and Bredesen DE. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ 2004; 11:1066-1075. Yokota T, Miyagishi M, Hino T, Matsumura R, Tasinato A, Urushitani M, Rao RV, Takahashi R, Bredesen DE, Taira K, and Mizusawa H. siRNA-based inhibition specific for mutant sod1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem Biophys Res Commun 2004; 314:283-291

2003

Ellerby HM, Lee S, Ellerby LM, Chen SF, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem 2003; 278:35311-35316.

Galvan V, Logvinova A, Sperandio S, Ichijo H, and Bredesen DE. Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem 2003; 278:13325-32.

Kurakin A, Wu S, Bredesen DE. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening (TAIS). J Biol Chem 2003, 278:34102-9.

Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. Amyloid b-protein toxicity mediated by the formation of amyloid-b protein precursor complexes. Annals of Neurology 2003, 54:78-89.

Lu DC, Soriano S, Bredesen DE, Koo EH. Caspase cleavage of the amyloid precursor protein modulates amyloid -protein toxicity. J Neurochem 2003; 87:733-74

Mehlen P, Bredesen DE. Meeting report: cellular dependence#old concept, new mechanisms. Sci STKE 2003, 2003(213): pe55.

Peel A, Mucke L, Bredesen DE. Activation of the cell stress kinase PKR in Alzheimer’s disease and human amyloid precursor protein transgenic mice. Neurobiol Dis 2003; 14:52-62. Rabizadeh S and Bredesen DE. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). Cytokine Growth Factor Rev 2003; 14:225-39. 

2002

Arap W, Haedicke W, Bernasconi M, Kain R, Rajotte D, Krajewski S, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E. Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci U S A 2002; 99: 1527-31.

Castro-Obregon S, Del Rio G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls DG, Bredesen DE. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ 2002; 9: 807-17.

Frankowski H, Castro-Obregon S, del Rio G, Rao RV, Bredesen DE. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. J Neuromolec Med 2002; 1: 153-70.

Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem 2002; 82: 283-94.

Kurakin A, Bredesen D. Target assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk Proteins. J Biomol Struct Dyn 2002; 19: 1-15.

Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, Del Rio G, Bredesen DE, Ellerby HM. Coupling endoplasmic reticulum stress to the cell death program: an apaf-1-independent intrinsic pathway. J Biol Chem 2002; 277: 21836-42.

Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett 2002; 514: 122-8.

Wellington C, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham R K, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen DE, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J Neurosci 2002; 33: 7862-72.

2001

Bredesen DE. Neurodegenerative disease and cancer: two sides of a coin? Hosp Pract (Off Ed) 2001; 36: 39-42, 45.

del Rio G, Bartley TF, del-Rio H, Rao R, Jin K, Greenberg DA, Eshoo M, Bredesen DE. Mining DNA microarray data using a novel approach based on graph theory. FEBS Lett 2001; 509: 230-34.

del Rio G, Castro-Obregon S, Rao R, Ellerby HM, Bredesen DE. APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide. FEBS Lett 2001; 494: 213-9.

Ethell DW, Bossy-Wetzel E, Bredesen DE. Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non- consensus motif, in vitro. Biochim Biophys Acta 2001; 1541: 231-8.

Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE, Mehlen P. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci U S A 2001; 98: 3416-21.

Gerlag DM, Borges E, Tak PP, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E, Firestein GS. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res 2001; 3: 357-61.

Lee M, Hyun DH, Marshall KA, Ellerby LM, Bredesen DE, Jenner P, Halliwell B. Effect of overexpression of Bcl-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radic Biol Med 2001; 31: 1550-59.

Lee S, Furuya T, Kiyota T, Takami N, Murata K, Niidome Y, Bredesen DE, Ellerby HM, Sugihara G. De novo-designed peptide transforms Golgi-specific lipids into Golgi- like nanotubules. J Biol Chem 2001; 276: 41224-8.

Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby LM, Bredesen DE. Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue. Hum Mol Genet 2001; 10: 1531-8.

Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 2001; 276: 33869-74.

Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro- caspases, is the most likely route. J Biol Chem 2001; 276: 3149-57.

Zhong LT, Manzi A, Skowronski E, Notterpek L, Fluharty AL, Faull KF, Masada I, Rabizadeh S, Varsanyi-Nagy M, Ruan Y, Oh JD, Butcher LL, Bredesen DE. A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker. Cancer Res 2001; 61: 5741-8.

2000

Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P. The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. Embo J 2000; 19: 4056-63.

Bredesen DE. Apoptosis: overview and signal transduction pathways. J Neurotrauma 2000; 17: 801-10.

Cafe C, Testa MP, Sheldon PJ, French WP, Ellerby LM, Bredesen DE. Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants. J Mol Neurosci 2000; 15: 71-83.

Ellerby LM, Bredesen DE. Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis. Methods Enzymol 2000; 322: 413-21.

Kelner GS, Lee M, Clark ME, Maciejewski D, McGrath D, Rabizadeh S, Lyons T, Bredesen D, Jenner P, Maki RA. The copper transport protein Atox1 promotes neuronal survival. J Biol Chem 2000; 275: 580-4.

Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD. Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation. J Biol Chem 2000; 275: 16127-33.

Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid -protein precursor. Nature Med 2000; 6: 397-404.

Mehlen P, Bredesen DE. [Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]. Bull Cancer 2000; 87: 537-41.

Rabizadeh S, Ye X, Sperandio S, Wang JJ, Ellerby HM, Ellerby LM, Giza C, Andrusiak RL, Frankowski H, Yaron Y, Moayeri NN, Rovelli G, Evans CJ, Butcher LL, Nolan GP, Assa-Munt N, Bredesen DE. Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor. J Mol Neurosci 2000; 15: 215-29.

Sperandio S, de Belle I, Bredesen DE. An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A 2000; 97: 14376-81.

Wang JJ, Rabizadeh S, Tasinato A, Sperandio S, Ye X, Green M, Assa-Munt N, Spencer D, Bredesen DE. Dimerization-dependent block of the proapoptotic effect of P75(NTR). J Neurosci Res 2000; 60: 587-93.

Wang JJ, Tasinato A, Ethell DW, Testa MP, Bredesen DE. Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities. J Mol Neurosci 2000; 15: 19-29.

Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM. Neuronal apoptosis induced by pharmacological concentrations of 3- hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression. J Neurochem 2000; 75: 81-90.

Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J Biol Chem 2000; 275: 19831 - 19838.

1999

Bredesen DE. The emerging relationship between developmental and degenerative neural cell death. Neural Notes 1999; 70: 31-9.

Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides. Nature Med 1999; 5: 1032-8.

Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem 1999; 274: 8730-6.

Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 1999; 72: 185-95.

Hong CS, Caromile L, Nomata Y, Mori H, Bredesen DE, Koo EH. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. J Neurosci 1999; 19: 637-43.

Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. FEBS Lett 1999; 460: 191-8.

Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A 1999; 96: 5752-7.

Rabizadeh S, Ye X, Wang JJ, Bredesen DE. Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF. Cell Death Differ 1999; 6: 1222-27.

Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem 1999; 274: 30202-8.

1998

Bredesen DE, Ye X, Tasinato A, Sperandio S, Wang JJ, Assa-Munt N, Rabizadeh S. p75NTR and the concept of cellular dependence: seeing how the other half die. Cell Death Differ 1998; 5: 365-71.

Bruce-Keller AJ, Begley JG, Fu W, Butterfield DA, Bredesen DE, Hutchins JB, Hensley K, Mattson MP. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid -peptide. J Neurochem 1998; 70: 31-9.

Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 1998; 95: 4997-5002.

Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nat Genet 1998; 18: 150-4.

Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 1998; 395: 801-4.

Spear N, Estevez AG, Johnson GV, Bredesen DE, Thompson JA, Beckman JS. Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2. Arch Biochem Biophys 1998; 356: 41-5.

Stennicke HR, Jurgensmeier JM, Shin H, deveraux QL, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 1998; 273: 27084-90.

Wei H, Wei W, Bredesen DE, Perry DC. Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores. J Neurochem 1998; 70: 2305-14.

Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem 1998; 273: 9158-67.

1997

Bredesen DE, Ellerby LM, Hart PJ, Wiedau-Pazos M, Valentine JS. Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis? Ann Neurol 1997; 42: 135-7.

Bredesen DE, Rabizadeh S. p75NTR and apoptosis: Trk-dependent and Trk-independent effects. Trends Neurosci 1997; 20: 287-90.

Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci 1997; 17: 6165-78.

Hileman MR, Chapman BS, Rabizadeh S, Krishnan VV, Bredesen D, Assa-Munt N, Plesniak LA. A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation. FEBS Lett 1997; 415: 145-54.

Keane RW, Srinivasan A, Foster LM, Testa MP, Ord T, Nonner D, Wang HG, Reed JC, Bredesen DE, Kayalar C. Activation of CPP32 during apoptosis of neurons and astrocytes. J Neurosci Res 1997; 48: 168-80.

Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 1997; 17: 5089-100.

Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 1997; 137: 1581-8.

Ruan Y, Rabizadeh S, Camerini D, Bredesen DE. Expression of CD40 induces neural apoptosis. J Neurosci Res 1997; 50: 383-90.

Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci 1997; 17: 7594-605.

1996

Bredesen DE. Genetic control of neural cell apoptosis. Perspect Dev Neurobiol 1996; 3: 101-9.

Bredesen DE, Wiedau-Pazos M, Goto JJ, Rabizadeh S, Roe JA, Gralla EB, Ellerby LM, Valentine JS. Cell death mechanisms in ALS. Neurol 1996; 47: S36-8; discussion S38-9.

Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem 1996; 67: 1259-67.

Kayalar C, Ord T, Testa MP, Zhong LT, Bredesen DE. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci U S A 1996; 93: 2234-8.

Lyons TJ, Liu H, Goto JJ, Nersissian A, Roe JA, Graden JA, Cafe C, Ellerby LM, Bredesen DE, Gralla EB, Valentine JS. Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein. Proc Natl Acad Sci U S A 1996; 93: 12240-4.

Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A 1996; 93: 9893-8.

Sarafian TA, Bredesen DE, Verity MA. Cellular resistance to methylmercury. Neurotoxicology 1996; 17: 27-36.

Srinivasan A, Foster LM, Testa MP, Ord T, Keane RW, Bredesen DE, Kayalar C. Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J Neurosci 1996; 16: 5654-60.

Wiedau-Pazos M, Goto JJ, Rabizadeh S, Gralla EB, Roe JA, Lee MK, Valentine JS, Bredesen DE. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 1996; 271: 515-8.

Wiedau-Pazos M, Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE. Expression of bcl-2 inhibits cellular radical generation. Free Radic Res 1996; 24: 205-12.

1995

Anton R, Kordower JH, Kane DJ, Markham CH, Bredesen DE. Neural transplantation of cells expressing the anti-apoptotic gene bcl- 2. Cell Transplant 1995; 4: 49-54.

Bredesen DE. Neural apoptosis. Ann Neurol 1995; 38: 839-51.

Hisanaga K, Kure S, Bredesen DE, Ikeda Y, Kohsaka S, Sharp FR. Apoptotic cell death of a temperature-sensitive central neuronal cell line. Brain Res 1995; 684: 79-86.

Kane DJ, Ord T, Anton R, Bredesen DE. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res 1995; 40: 269-75.

Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, Murphy AN. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem 1995; 65: 2432-40.

Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci U S A 1995; 92: 3024-8.

Verity MA, Bredesen DE, Sarafian T. Role of reactive oxygen species (ROS) in neuronal degeneration. Modulation by protooncogene expression. Ann N Y Acad Sci 1995; 765: 340.

1994

Anton R, Kordower JH, Maidment NT, Manaster JS, Kane DJ, Rabizadeh S, Schueller SB, Yang J, Edwards RH, Bredesen DE, et al. Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp Neurol 1994; 127: 207-18.

Rabizadeh S, Bitler CM, Butcher LL, Bredesen DE. Expression of the low-affinity nerve growth factor receptor enhances -amyloid peptide toxicity. Proc Natl Acad Sci U S A 1994; 91: 10703-6.

Rabizadeh S, Bredesen DE. Is p75NGFR involved in developmental neural cell death? Dev Neurosci 1994; 16: 207-11.

Sarafian TA, Bredesen DE. Is apoptosis mediated by reactive oxygen species? Free Radic Res 1994; 21: 1-8.

Sarafian TA, Vartavarian L, Kane DJ, Bredesen DE, Verity MA. bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line. Toxicol Lett 1994; 74: 149-55.

1993

Bredesen DE. Potential role of gene therapy in the treatment of Parkinson's disease. Neuroscience 1993; 1: 45-52.

Foster LM, Phan T, Verity AN, Bredesen D, Campagnoni AT. Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation. Dev Neurosci 1993; 15: 100-9.

Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993; 262: 1274-7.

Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE. The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J Neurochem 1993; 60: 1183-6.

Rabizadeh S, LaCount DJ, Friesen PD, Bredesen DE. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J Neurochem 1993; 61: 2318-21.

Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE. Induction of apoptosis by the low-affinity NGF receptor. Science 1993; 261: 345-8.

Verity AN, Bredesen D, Vonderscher C, Handley VW, Campagnoni AT. Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus. J Neurochem 1993; 60: 577-87.

Zhong LT, Kane DJ, Bredesen DE. BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res 1993; 19: 353-5.

Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, Bredesen DE. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A 1993; 90: 4533-7.

1992

Singer EJ, Bredesen DE, Baringer JR. Cognitive dysfunction in an HIV-infected patient. Hosp Pract (Off Ed) 1992; 27: 91-9, discussion 99-100.

Yang J, Seelig M, Rayner S, Bredesen DE. Increasing the proliferative capacity of muscular dystrophy myoblasts. Muscle Nerve 1992; 15: 941-8.

1990

Bredesen DE, Hisanaga K, Sharp FR. Neural transplantation using temperature-sensitive immortalized neural cells: a preliminary report. Ann Neurol 1990; 27: 205-7.

Kahn JO, Kaplan LD, Gambertoglio JG, Bredesen D, Arri CJ, Turin L, Kibort T, Williams RL, Lifson JD, Volberding PA. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. Aids 1990; 4: 1197-204.

Levy RM, Bredesen DE, Rosenblum ML. Neurologic complications of HIV infection. Am Fam Physician 1990; 41: 517-36.

Levy RM, Mills CM, Posin JP, Moore SG, Rosenblum ML, Bredesen DE. The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study. J Acquir Immune Defic Syndr 1990; 3: 461-71.

1989

Engstrom JW, Lowenstein DH, Bredesen DE. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med 1989; 86: 528-32.

Ho DD, Bredesen DE, Vinters HV, Daar ES. The acquired immunodeficiency syndrome (AIDS) dementia complex [clinical conference]. Ann Intern Med 1989; 111: 400-10.

1988

Bredesen DE, Levy RM, Rosenblum ML. The neurology of human immunodeficiency virus infection. Q J Med 1988; 68: 665-77.

Levy RM, Bredesen DE. Central nervous system dysfunction in acquired immunodeficiency syndrome. J Acquir Immune Defic Syndr 1988; 1: 41-64.

Levy RM, Bredesen DE, Rosenblum ML. Opportunistic central nervous system pathology in patients with AIDS. Ann Neurol 1988; 23: S7-12.

Rosenblum ML, Levy RM, Bredesen DE. Neurosurgical implications of the acquired immunodeficiency syndrome (AIDS). Clin Neurosurg 1988; 34: 419-45.

Rosenblum ML, Levy RM, Bredesen DE, So YT, Wara W, Ziegler JL. Primary central nervous system lymphomas in patients with AIDS. Ann Neurol 1988; 23: S13-6.

Scott MR, Butler DA, Bredesen DE, Walchli M, Hsiao KK, Prusiner SB. Prion protein gene expression in cultured cells. Protein Eng 1988; 2: 69-76.

1985

Dix RD, Bredesen DE, Erlich KS, Mills J. Recovery of herpes viruses from cerebrospinal fluid of immunodeficient homosexual men. Ann Neurol 1985; 18: 611-4.

Levy RM, Bredesen DE, Rosenblum ML. Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. J Neurosurg 1985; 62: 475-95.

Parry GJ, Bredesen DE. Sensory neuropathy with low-dose pyridoxine. Neurology 1985; 35: 1466-8.

1984

Raskin NH, Bredesen D, Ehrenfeld WK, Kerlan RK. Periodic confusion caused by congenital extrahepatic portacaval shunt. Neurology 1984; 34: 666-9.

1983

Cutler JR, Bredesen DE, Edwards R, Simon RP. Failure of naloxone to reverse vascular neurologic deficits. Neurology 1983; 33: 1517-8.

1978

McCarty KS, Bredesen DE, Vogel FS. Neoplasms of the anterior pituitary. Neurosurgery 1978; 3: 96-104.

1977

Bredesen DE, McCarty KS, Jr, D. S, Kramer R, Hammond C. Ultrastructural effects of 2-bromoergocryptine on prolactin-producing human pituitary adenomas. Proc Elec Micro Soc Amer 1977; 536-37.

1973

Wrighton M, Bredesen DE. Photochemistry of aquo- and hydroxopenta-cyanocobaltate (III). Inorg Chem 1973; 12: 1707-09.

Wrighton M, Bredesen DE. Symmetrical cleavage of the metal-metal bond in decacarbonyldirhenium (O) by ultraviolet irradiation. J Organmet Chem 1973; 50: C35-C38.

1972

Wrighton M, Bredesen DE, Hammond GS, Gray HB. Deactivation of biacetyl triplets by cyanocobaltate (III) complexes. J Am Chem Soc, Chem Comm 1972; 18: 1018-19.

 
X
Buck Institute for age research Extending The Healthy
Years Of Life

Yes! I'd like to support the Buck Institute for Age Research and help scientists in their efforts to add healthy years to our lives.

There are three easy ways to make a gift to the Buck Institute today:

  1. EASY! :Write a check made payable to Buck Institute for Age Research and mail your gift to:
    Office of Development
    Buck Institute for Age Research
    8001 Redwood Boulevard
    Novato, CA 94945
  2. EASIER!! :Call 415-209-2261 and give your credit card number and the amount of your gift over the phone.
  3. EASIEST!!! :Enter the amount you chose to give and click on the Google checkout tab on this page.
* Gifts of stock or planned gifts can also be made - please call 209.2262 for more information All contributions are tax-deductible to the extent of the law. As a donor you will receive our newsletter Healthspan, advance notice of upcoming seminars, invitations to donor-only events, and recognition in our Annual Report of Private Giving.

THANK YOU!

$