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Gordon J. Lithgow

Selected Publications

  • ·         McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P and Lithgow GJ (2010).  Insulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.Cell Metabolism, In Press. PMCID: PMC Journal - In Process.
    ·         RogersAN, Czerwieniec G, Chen D, McColl G, Felkey K, Melov S, GibsonB, HubbardA, LithgowGJ, KapahiP. (2009). Post-transcriptional remodeling of longevity and stress response gene expression by inhibition of eIF-4G is linked to mRNA length. Cell Metabolism. PMCID: PMC Journal - In Process.
    ·         Bhaumik D, Scott G.K,  Schokrpur S, Patil CK, Orjalo, AV, Rodier, F, Lithgow, GJ, and Campisi J (2009). MicroRNAs, miR-146a/b, negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 1(4):402-412. PMCID: PMC2818025.
    ·         Benedetti MG, Foster AL, Vantipalli  MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ (2008). Compounds that confer thermal stress resistance and extended lifespan. Experimental Gerontology. 43: 882-91. PMCID:PMC 2603168.
    ·         Fisher AL, Page  K, Lithgow GJ, Nash L (2008). The C. elegans K10C2.4 Gene Encodes a Member of the Fumarylacetoacetate Hydrolase Family. A C. elegans Model of Type I Tyrosinemia. J. Biological Chemistry 283 (14) 9127-9135. (doi:10.1074/jbc.M708341200). PMCID:PMC 2431024.
    ·         McColl G, Killilea,  DW, Hubbard, AE, Vantipalli, MC, Melov, S, and Lithgow, GJ(2008). Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans.J. Biological Chemistry 283:350-357. PMCID:PMC 2739662
    ·         Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ and Kapahi P (2007). Inhbition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6:111-1119. PMCID: PMC2745345.
    ·         Olsen A, Vantipalli  MC and Lithgow GJ (2006). Checkpoint Proteins Regulate Survival of the Post-Mitotic Adult Soma in Caenorhabditis elegans. Science312: 1381-1385.
    ·         Olsen A, Vantipalli MC and Lithgow GJ (2006). Lifespan Extension of C. elegans following repeated Mild Hormetic Heat Treatments. Biogerontology 7(4):221-30. 
    ·         Olsen A,, Vantipalli MC and Lithgow GJ (2006). Using Caenorhabditis elegans as a Model for Aging and Age-Related diseases. Ann. N.Y. Acad. Sci 1067:120-128.
    ·         Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS (2006). DAF-12 dependent rescue of dauer formation in Caenorhabditis elegans by (25S) cholestenoic acid.  Aging Cell 5: 283-91.
    ·         Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow GJ, Srinivasan C (2006). Manganous ion supplementation accelerates wild-type development, enhances stress resistance and resuces the life span of a short-lived Caenorhabditis elegans mutant. Free Rad Biol & Med. 40:1185-1193.
    ·         Lithgow GJ and Andersen JK (2006). Models of Oxidative Stress in the biology of aging. Drug Discovery Today: Disease Models 2(4):273-277.
    ·         Fisher A. and Lithgow GJ (2005). The Nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell 5:1277-138.
    ·         McColl G, Vantipalli MC and Lithgow GJ (2005). C elegans ortholog of mammalian Ku70, Interacts with Insulin-like signaling to Modulate Stress Resistance and Lifespan. FASEB J. 19 (12):1716-1718.
    ·         Jenkins N, McColl G and Lithgow GJ (2004). The fitness cost of extended lifespan in Caenorhabditis elegans. Proceedings of the The Royal Society. B. 271,2523-2526.
    ·         Gill MS, Held JM, Fisher AL, Gibson BW and Lithgow GJ (2004). Lipophilic regulators of a developmental switch in Caenorhabditis elegans. Aging Cell. 3, 413-421.
    ·         Sampayo JN, Olsen A, Lithgow GJ (2003). Oxidative Stress in C. elegans – protective effects of Superoxide dismutase/Catalase mimetics. Aging Cell 2:319-326.
    ·         Gill MS, Olsen A, Sampayo JN and Lithgow GJ (2003). An automated high-through-put assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med, 35 (6): 558-565.
    ·         Walker GA and Lithgow GJ (2003). Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell, 2:131-139.
  
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