The Science The Institute The Science Get Involved Healthy aging

Kim SH, Kaminker P, Campisi J. (1999) Tin2, a new regulator of telomere length in human cells. Nature Genetics 23: 405-412.

Campisi J. (1999) Cell senescence, aging and cancer. In: Molecular Biology of Aging, Alfred Benzon Symposium 44: 112-118.

Campisi J. (1999) Cellular aging/Replicative senescence. In: Studies of Aging/Springer Lab Manual; Sternberg H, Timiras PS, eds. Springer-Verlag, Berlin, pp 35-45.

Campisi J. (1999) Replicative senescence and immortalization. In: The Molecular Basis of Cell Cycle and Growth Control; Stein G, Baserga R, Giordano A, Denhardt D, eds. Wiley-Liss, NY, pp 348-373.

Dimri GP, Acosta M, Itahana K, Campisi J. (2000) Regulation of a senescence checkpoint by the E2F1 transcription factor and p14/ARF tumor suppressor. Molec Cell Biol 20: 273-285.

Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, Desprez PY. (2000) A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 60: 1332-1340.

Campisi J. (2000) Cancer, aging and cellular senescence. In Vivo 14: 183-188.

Xu W, Haddad MM, Bischof O, Campisi J, Medrano EE. (2000) Regulation of Microphtalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. Exp Cell Res 255: 135-143.

Xu W, Haddad MM, Angelis K, Shardy DL, Bischof O, Campisi J, Stavenezer E, Medrano EE. (2000) SKI acts as a co-repressor of Smad2 and Smad3 to regulate the response to TGF-b. Proc Natl Acad Sci USA 97: 5924-5929.

Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J. (2000) Characterization of the human and mouse WRN 3' to 5' exonuclease. Nucl Acids Res 28: 2396-2405.

Campisi J. (2000) Aging chromatin and caloric restriction: Connecting the dots. Science 289: 2062-2063.

Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, Li GC, Campisi J, Kohwi-Shigematsu T, Chen DJ. (2000) Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 14: 2807-2812.

Campisi J, Warner HR. (2001) Aging in mitotic and post-mitotic cells. In: The role of DNA damage and repair in aging. Gilchrest B, Bohr W, eds. Adv Cell Aging & Gerontol 4: 1-16.

Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J. (2001) Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death. J Biol Chem 276: 12068-12075.

Campisi J. (2001) From cells to organisms: Can we learn about aging from cells in culture? Exp Gerontol 36: 607-618.

Bischof O, Kim SH, Irving J, Beresten S, Ellis NA, Campisi J. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153: 367-380.

Bandhyopadhyay D, Timchenko N, Suwa T, Hornsby PJ, Campisi J, Medrano EE. (2001) The human melanocyte: A model system to study the complexity of cellular aging and transformation in non-fibroblastic cells. Exp Gerontol 36: 1265-1275.

Itahana K, Dimri GP, Campisi J. (2001) Regulation of cellular senescence by p53. Eur J Biochem 268: 2784-2791.

Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P, Campisi J. (2001) TANK2, a new TRF1-associated PARP, causes rapid induction of cell death upon overexpression. J Biol Chem 276: 35891-35899.

Yannone SM, Roy S, Chan D, Murphy M, Huang S, Campisi J, Chen D. (2001) Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem 276: 38242-38248.

Krtolica A, Parrinello S, Lockett S, Desprez P, Campisi J. (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 98: 12072-12077.

Campisi J. (2001) Cellular senescence as a tumor suppressor mechanism. Trends Cell Biol 11: 27-31.

Parrinello S, Lin CQ, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez PY (2001) Id-1, ITF-2 and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation and apoptosis. J Biol Chem 276: 39213-39219.

Campisi J, Kim, SH, Lim CS, Rubio M. (2001) Cellular senescence, cancer and aging: The telomere connection. Exp Gerontol 36: 1619-1637.

Lim CS, Mian IS, Dernburg A, Campisi J. (2001) C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol 11: 1706-1710.

Oshima J, Huang S, Pae C, Campisi J, Schiestl RH. (2002) Lack of WRN facilitates extensive deletion at non-homologous joining ends. Cancer Res 62: 547-551.

Kim SH, Kaminker PG, Campisi J. (2002) Telomeres, cancer and aging: In search of a happy ending. Oncogene 21: 503-511.

Campisi, J. (2002) Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev 123: 567-573.

Itahana K, Dimri GP, Hara E, Itahana Y, Zou Y, Desprez P, Campisi J. (2002) A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem 277: 18206-18214.

Rubio MA. Kim SH, Campisi J. (2002) Reversible manipulation of telomerase expression and telomere length: Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem 277: 28609-28617.

Dimri GP, Martinez JL, Jacobs J, Keblusek P, Itahana K, van Lohuizen M, Campisi J, Wazer DE, Band V. (2002). BMI-1 oncogene induces telomerase and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745.

Krtolica A, Campisi J. (2002) Cancer and aging: A model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 34: 1401-1414.

Krtolica A, Ortiz de Solorzano C, Lockett S, Campisi J. (2002 Quantification of epithelial cell proliferation in co-culture with fibroblasts by fluorescence image analysis. Cytometry 49: 73-82.

Campisi J. (2002) Cellular senescence and cell death. In Physiological Basis of Aging and Geriatrics; Timiras PS, ed, CRC Press, Boca Raton FL; pp. 47-60.

Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs J, van Lohuizen M, Band V, Campisi J, Dimri GP. (2003) Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Molec Cell Biol 23: 389-401.

Campisi J. (2003) Cellular senescence and apoptosis: How cellular responses may influence aging phenotypes. Exp Gerontol 38: 5-11.

Campisi J. (2003) Cellular senescence. In: Chromosomal Instability and Aging: Basic Science and Clinical Implication; Hisama FM, Weissman SM, Martin GM, eds, Marcel Dekker, NY; pp 29-49.

Hasty P, Campisi J, Hoeijmakers J, Van Steeg H, Vijg J. (2003) Aging and genome maintenance: Lessons from the mouse? Science 299: 1355-1359.

Kim SH, Parrinello S, Kim J, Campisi J. (2003) Mus musculus and Mus spretus homologues of the human telomere associated protein TIN2. Genomics 81: 422-432.

Campisi J. (2003) Analysis of tumor suppressor gene-induced senescence. Methods Mol Biol 223: 155-171.

Campisi J. (2003) Cancer and ageing: Rival Demons? Nature Cancer Rev 3: 339-349.

Krtolica A, Campisi J. (2003) Integrating epithelial cancer, aging stroma and cellular senescence. Adv Gerontol 11: 109-116.

Kim SH, Han S, You YH, Chen DJ, Campisi J. (2003) The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 4: 685-691.

Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. (2003) Oxygen sensitivity severely limits the replicative life span of murine cells. Nature Cell Biol 5: 741-747.

Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe S, Yaswen Y, Campisi J. (2003) Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J 22: 4212-4222.

Chen LJ, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J. (2003) WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2: 191-199.

Davalos A, Campisi J. (2003) Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 162: 1197-1209.

Tan S, Guschin D, Davalos A, Lee YL, Snowden AW, Jouvenot Y, Zhang HS, Howes K, McNamara AR, Lai A, Ullman C, Reynolds L, Moore M, Isalan M, Berg LP, Campos B, Qi H, Spratt SK, Case CC, Pabo CO, Campisi J, Gegrory PD. (2003) ZFP-target gene regulation: Genome-wide single gene specificity. Proc Natl Acad Sci USA 100: 11997-12002.

Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavenezer E, Campisi J, Fisher DE, Ben-Ze'ev A, Medrano EE. (2003) SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res 63: 6626-6634.

Busuttil RA, Rubio M, Dolle MET, Campisi J, Vijg J. (2003) Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2: 287-294.

Campisi J. (2004) Fragile fugue: p53 in aging, cancer and IGF signaling. Nature Med 10: 231-232.

Itahana K, Campisi J, Dimri GP. (2004) Mechanisms of cellular senescence in human and mouse cells. Biogerontol 5: 1-10.

Rubio M, Davalos A, Campisi J (2004) Telomere length regulates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res.298: 17-27.

Chiang J, Hatchcock K, Kim SH, Campisi J, Hodes R. (2004) Telomere associated protein TIN2 is essential for early embryonic development through a telomerase independent pathway. Molec Cell Biol 24: 6631-6634.

Busuttil RA, Dolle M, Campisi J, Vijg J. (2004) Genomic instability, aging and cellular senescence. Ann NY Acad Sci 1019: 245-255.

Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J. (2004) TIN2 mediates the functions of TRF2 at telomeres. J Biol Chem 279:43799-43804.

Davalos AR, Kaminker P, Hansen RK, Campisi J. (2004) ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activity and 53BP1 focus formation. Cell Cycle 3: 1579-1586.

Campisi J. (2005) Aging, tumor suppression and cancer: High wire act! Mech Ageing Dev. 126: 51-58.

Parrinello S, Coppe JP. Krtolica A, Campisi J. (2005) Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts can alter epithelial cell differentiation. J Cell Sci 118: 485-496.

Campisi J. (2005) Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors. Cell 120: 1-10.

Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. (2005) Cancer and aging: The importance of telomeres in genome maintenance. Int J Bioch Cell Biol 37: 977-990.

Kaminker P, Plachot C, Kim SH, Chung P, Crippin D, Petersen OW, Bissell MJ, Campisi J, Lelievere SA. (2005) Higher order nuclear organization in growth arrest of human mammary epithelial cells: A novel role for telomere-associated protein TIN2. J Cell Sci 118: 1321-1330.

  
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