Kapahi Lab

Selected publications

• Katewa SD and Kapahi P. Dietary Restriction and Aging. Aging Cell, 2010 (epub ahead of print).

• Kapahi P and Vijg J. Aging - lost in translation? New England Journal of Medicine, 2009, 361(27): 2669-70.

• Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P. 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila.  Cell. 2009 Oct 2;139(1):149-60. http://www.cell.com/abstract/S0092-8674(09)00914-3

  • Perspective by Kennedy BK and Mackay VL. Translate this...during dietary restriction . Cell Metabolism. 2009 Oct 7; 10:247-248

• Kaeberlein M, Kapahi P. Aging is RSKy business. Science 2009. 326(5949)55-6

• Kaeberlein M, Kapahi P. The hypoxic response and aging. Cell Cycle, 2009 Aug:8 (15):2324. www.landesbioscience.com/journals/cc/article/CCInOtherNews8-15.pdf

  Edman U; Garcia A M; Busuttil R; Sorensen D; Lundell M; Kapahi P; Vijg J. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell; 2009 8(3): 331-338.

• Chen, D; Thomas E L; Kapahi P. HIF-1 Modulates Dietary Restriction-mediated Lifespan Extension via IRE-1 in C. elegans. PLOS Genetics; 2009 5(5):e1000486. www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000486

• Bell R; Hubbard A; Chettier R; Chen D; Miller J P; Kapahi P; Tarnopolsky M; Sahasrabuhde S; Melov S; Hughes R E. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genetics 2009 5(3): e1000414. www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000414

• Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell, 2007, 6: 525-533. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746107/?tool=pubmed

• Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in C. elegans. Aging Cell. 2007. 6: 111–119 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745345/?tool=pubmed

• Rogers AN & Kapahi P. Genetic mechanisms of lifespan extension by dietary restriction. Drug Discovery Today: Disease Mechanisms, 2006 3:5-10. (PDF)

• Carvalho GB, Kapahi P, Anderson DJ, Benzer S. Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila. Curr Biol. 2006 Apr 4;16(7):692-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745344/?tool=pubmed

• Carvalho GB, Kapahi P, Benzer S. Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat Methods. 2005 Nov;2(11):813-5. (PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745347/?tool=pubmed

• Kapahi P, Zid B. TOR pathway: linking nutrient sensing to life span. Sci Aging Knowledge Environ. 2004 Sep 8;2004(36):PE34. Review. (PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754831/?tool=pubmed

• Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004 May 25;14(10):885-90. (PDF) (Supplemental data PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754830/?tool=pubmed

• Seroude L, Brummel T, Kapahi P, Benzer S. Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell. 2002 Oct;1(1):47-56.

• Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa β activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa β kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6. http://www.jbc.org/content/275/46/36062.long

• Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of Ikappaβ kinase. Nature. 2000 Jan 6;403(6765):103-8.

• Kapahi P, Boulton ME, Kirkwood TB. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med. 1999 Mar;26(5-6):495-500.