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Selected publications

  1. Vargas MA, Luo N, Yamaguchi A, Kapahi P. A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster. Curr Biol. 2010;20(11):1006-11. PMCID: 2885474.

  2. Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010;11(6):453-65. PMCID: 2885591.

  3. Katewa SD, Kapahi P. Dietary restriction and aging, 2009. Aging Cell. 2010;9(2):105-12.

  4. Kapahi P and Vijg J. Aging - lost in translation? New England Journal of Medicine, 2009, 361(27): 2669-70.

  5. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P. 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila.  Cell. 2009 Oct 2;139(1):149-60. http://www.cell.com/abstract/S0092-8674(09)00914-3

    • Perspective by Kennedy BK and Mackay VL. Translate this...during dietary restriction . Cell Metabolism. 2009 Oct 7; 10:247-248

  6. Kaeberlein M, Kapahi P. Aging is RSKy business. Science 2009. 326(5949)55-6

  7. Edman U; Garcia A M; Busuttil R; Sorensen D; Lundell M; Kapahi P; Vijg J. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell; 2009 8(3): 331-338.

  8. Chen, D; Thomas E L; Kapahi P. HIF-1 Modulates Dietary Restriction-mediated Lifespan Extension via IRE-1 in C. elegans. PLOS Genetics; 2009 5(5):e1000486. www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000486

  9. Bell R; Hubbard A; Chettier R; Chen D; Miller J P; Kapahi P; Tarnopolsky M; Sahasrabuhde S; Melov S; Hughes R E. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genetics 2009 5(3): e1000414. www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000414

  10. Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell, 2007, 6: 525-533. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746107/?tool=pubmed

  11. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in C. elegans. Aging Cell. 2007. 6: 111–119 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745345/?tool=pubmed

  12. Rogers AN & Kapahi P. Genetic mechanisms of lifespan extension by dietary restriction. Drug Discovery Today: Disease Mechanisms, 2006 3:5-10. (PDF)

  13. Carvalho GB, Kapahi P, Anderson DJ, Benzer S. Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila. Curr Biol. 2006 Apr 4;16(7):692-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745344/?tool=pubmed

  14. Carvalho GB, Kapahi P, Benzer S. Compensatory ingestion upon dietary restriction in Drosophila melanogaster. Nat Methods. 2005 Nov;2(11):813-5. (PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745347/?tool=pubmed

  15. Kapahi P, Zid B. TOR pathway: linking nutrient sensing to life span. Sci Aging Knowledge Environ. 2004 Sep 8;2004(36):PE34. Review. (PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754831/?tool=pubmed

  16. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004 May 25;14(10):885-90. (PDF) (Supplemental data PDF) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754830/?tool=pubmed

  17. Seroude L, Brummel T, Kapahi P, Benzer S. Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell. 2002 Oct;1(1):47-56.

  18. Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa β activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa β kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6. http://www.jbc.org/content/275/46/36062.long

  19. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of Ikappaβ kinase. Nature. 2000 Jan 6;403(6765):103-8.

  20. Kapahi P, Boulton ME, Kirkwood TB. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med. 1999 Mar;26(5-6):495-500.

 

  
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